Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 22 for “"neuronal systems"”.
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Memristive Devices For Neuronal Systems
… in brains and how we can build up non-biological systems, which function similar to those. In particular, I focused on the usage of new non-volatile memory technologies and electronic circuits for neuromorphic systems. Thus, the development of non-volatile devices and electronic circuits as well …
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Characterization of Novel Serotonin Metabolites in Selected Model Neuronal Systems
Novel 5-HT pathways were identified in Aplysia and Pleurobranchaea californica and Rattus norvegicus, via a capillary electrophoresis system with wavelength-resolved fluorescence detection. This method allows sensitive indole detection from samples as small as single cells. Compounds that natively …
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Integrate-and-fire modelling of neuronal systems with modulatory properties
The mathematical modelling of behaviour at the single neuron level is an important part of computational neuroscience. Conductance-based models remain dominant because of their biophysical interpretation. Nevertheless, their high dimensionality and number of parameters complicate mathematical …
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Development and application of innovative technologies to unravel neuronal systems: From optogenetics to neural interfaces to spatial transcriptomics
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2027-05-01
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Nonlinear dynamics and statistical physics of excitable systems
In the search for the mechanisms of neuronal information coding, attention has recently shifted towards the possible role of neuronal firing correlation. The present thesis addresses the question of how coupled neuronal systems synchronize. Neurons can be described as dynamical systems through the …
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Connectome and Ultrastructural Studies of an Anthozoan Planula: Exaiptasia diaphana
Nervous systems are complex networks that allow animals to sense their environment and coordinate specific reactions. However, little is known about their origin and how the first neuronal circuits functioned. The sea anemone Exaiptasia diaphana, a cnidarian and sister group to all bilaterians, …
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Neuropeptidomics Across Metazoan Life
… the formation, function and plasticity of neuronal networks, while the honey bee (Apis mellifera) is important for uncovering the mechanisms and evolution of social behavior. As studies in these model organisms are undertaken, knowledge of the complement of neuropeptides used by and …
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Feedback for neuronal system identification
… a process with a fading memory. Non-equilibrium systems such as neuronal and chaotic models lack a fading memory. Their identification is challenging, in particular in the presence of input noise. In this thesis, we propose a methodology based on the prediction-error method for the identification …
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The neuropsychological investigation of dyslexic readers: an experimental approach to subtyping
Based on Luria's notion of functional neuronal systems, reading has been hypothesized to require the adequate functioning of both the anterior and posterior cerebrum. Failure to be able to read has been hypothesized to be the result of dysfunction occurring anywhere throughout those functional …
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The Effect of Gonadal Steroids and Altered Tryptophan Metabolism on behaviour
… synthesis, end consequently, serotoninergic neuronal activity. Subsequent behavioural changes should result, and a primary aim of the research was to elucidate such changes within specific behavioural parameters. In order to discern more exactly the effect of gonadal steroids on behaviour, …
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Immunotherapy for Alzheimer’s Disease: IVIg Delivery to the Hippocampus in a Mouse Model of Amyloidosis
… (AD) is characterized by cognitive decline, neuronal degeneration and pathologies, which include toxic amyloid beta peptides (Aβ) and tau. To date, there is no cure for AD and therapies are only symptomatic. A Phase III clinical trial using intravenous immunoglobulins (IVIg) - natural …
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Zinc ion homeostasis in cellular physiology and experimental models of traumatic brain injury
… now believed to be signaling ions, especially in neuronal systems. This dissertation addresses the dynamics of [Zn2+]i and quantitatively defines its safe range in particular cell types. [Zn2+]i was measured to be pico- to nanomolar in undifferentiated and differentiated rat pheochromocytoma …
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Differential modulation of T-type voltage gated calcium channels by G-protein coupled receptors.
… channels play critical roles in controlling neuronal excitability, firing patterns, and synaptic plasticity, although the mechanisms and extent to which T-type Ca2+ channels are modulated by G-protein coupled receptors (GPCRs) remains largely unexplored. Investigations into T-type modulation …
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Using feed-forward networks to infer the activity of feedback neuronal networks
… system is one of the most important organ systems in a multicellular body. Animals, including human beings perceive, learn, think and deliver motion instructions through their nervous system. The basic structural units of the nervous system are individual neurons which constitute different …
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Inflammatory Cytokine Mediated CNS Damage: Insights Into the Effects of Tnf-Alpha From a Neuronal Cell Line
… cytokine that has been identified in directing neuronal response to disease or injury. Results are conflicting as to the role of TNF in mediating neuronal injury. TNF can protect neurons from excitotoxic and metabolic injury but can also mediate neuronal toxicity. We hypothesize that cell state …
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Dynamic weakening and trained memory in avalanche dynamics from high-entropy alloys to neurons and spin systems
… energy under slow external driving—arise in systems ranging from earthquakes and crystalline solids to neuronal networks and spin models. Despite differences in microscopic mechanisms, these systems share universal features such as broad event-size distributions and scale-invariant critical …
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Fluorescence resonance energy transfer-based subcellular visualization of FAK/Src activation by chemical and mechanical environment
… therapeutic tools to treat diseases related to neuronal systems and cancer.
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Mass spectrometry imaging for probing molecular distributions in the nervous system
Biological systems include a highly intertwined and complex set of interactions in which molecules vary spatially and temporally in addition to being present in concentrations that extend over many orders of magnitude. These chemical entities belong to numerous classes including inorganic salts, …
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Neuronal encoding of natural imagery in dragonfly motion pathways
… animals. While the act of seeing seems easy, the neuronal architectures that underlie this ability are some of the most complex of the brain. Insects represent an excellent model for investigating how vision operates as they often lead rich visual lives while possessing relatively simple brains. …
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Role of BDNF secretion and signaling in the activity-dependent refinement of synaptic connections
Neuronal networks exhibit diverse types of plasticity, including the activity-dependent regulation of synaptic functions and refinement of synaptic connections. In addition, continuous generation of new neurons in the “adult” brain (adult neurogenesis) represents a powerful form of structural …
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