Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 42 for “"neuronal survival"”.
-
The Role of ERK5 in Dopamine Neuronal Survival
… roles in neurogenesis, neutrite outgrowth, and neuronal viability in the central nervous system. In this study, ERK1, 2, and 5 expression and activation were examined in the substantia nigra (SN), striatum (STR), and ventral tegmental area (VTA) during postnatal development and normal aging …
-
Characterization of Alsin and Its Role in IGF-1-Mediated Neuronal Survival
… is required for motor neuron maintenance and/or survival, as loss-of-Alsin function results in multiple juvenile-onset neurodegenerative disorders (ALS2, JPLS, IAHSP). It was found here that Alsin is an endosomal protein that activates both Rac1 and Rab5. This protein is present in all of the …
-
Plxna4 and its role in neuronal survival in the developing zebrafish hindbrain
… apoptosis at 24 hpf. These data support a survival role for Plexina4 in the embryonic zebrafish hindbrain. Literature indicates that the secreted heat shock protein Clusterin is a candidate ligand to mediate apoptosis through Plexina4, as Clusterin is known to promote cell survival, and …
-
The exploitation of neuronal survival factors in Burkitt’s lymphoma and germinal centre B cells
… are neuromodulatory proteins utilised within neuronal networks for development and survival. Based on previous evidence revealing the expression of neurotrophin components in immune cells, the present study investigates neurotrophin component expression within Burkitt’s Lymphoma B cells. …
-
Ciliary neurotrophic factor signaling in the magnocellular neurosecretory system : mechanisms of neuronal survival and sprouting
… ciliary neurotrophic factor (CNTF) promotes the survival of a myriad of neuronal phenotypes, little is understood on the specific CNTF-induced neuroprotective mechanisms in the central nervous system (CNS). Elucidation of these mechanisms may provide insight that would assist in the development …
-
Effect of sinusoidal extremely low-frequency electromagnetic stimulation on neurons and glia in a transient stroke model
… immunomodulatory response, behavioral tests, neuronal survival, and glial reactivity were assessed in vivo and in vitro. Results showed that ELF-EMS improved neurological outcome, locomotion, habituation, and anxiety in ischemia /reperfusion models. ELF-EMS also increased neuronal survival in …
-
Neuroimmune Interactions of Enteric Neurons and Mast Cells: Friends or Foes?
… rat small and large intestine were used to study neuronal survival. The intestinal segments exposed to I/R were structurally well preserved, however, local areas containing numerous mast cells were detected in the muscle layers, the serosa and in and around the myenteric ganglia 4-20 weeks post …
-
Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to promote neuronal survival in a mouse model of neurodegeneration in which the appearance of DSBs precedes other neurotoxic symptoms. Here I show for …
-
Rho GTPases in Neuronal Apoptosis and Neurodegeneration
… essential role for Rho GTPases as regulators of neuronal morphology and neuronal survival. In particular, Rac GTPase generally induces neurite outgrowth and promotes neuronal survival while Rho GTPase typically provokes neurite retraction and induces neuronal apoptosis. However, the precise …
-
Activity-dependent integration and plasticity of new neurons during postnatal neurogenesis
… what form of activity pattern determines the survival of new neurons remains unclear. Using NaChBac sodium channels to selectively alter the intrinsic excitability of new neurons in vivo, this manipulation reveals that neuronal survival critically depends on the level of membrane …
-
Molecular and Genetic Analysis of Parkin in Microglia Activation and Inflammation-Related Neurodegeneration
… responses are a critical determinant of DA neuronal survival. Microglia support neuronal survival by providing trophic factors and phagocytosing debris. However, with chronic inflammation glia release chemical mediators which are toxic to surrounding neurons. Our data provide evidence that …
-
Immunoregulation of the central response to peripheral nerve injury: motoneuron survival and relevance to ALS
… interleukin 10 (IL-10) act centrally to promote neuronal survival after injury. This study first investigated the roles of IL-10 and CD4+ T cells in neuroprotection after axotomy. CD4+ T cell-mediated neuroprotection requires centrally-produced IL-10, but the source of IL-10 is unknown. Using FNA …
-
Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… excitotoxic damage in both WT and PrP KO neuronal cultures. Thus, in this model, PrP KO astrocytes exerted a functional influence on neuronal survival and may therefore influence regulation of glutamatergic neurotransmission in vivo.
-
Influence of Prion Protein Expression on Function of Excitatory Amino Acid Transporters in Mouse Primary Astrocytes
… excitotoxic damage in both WT and PrP KO neuronal cultures. Thus, in this model, PrP KO astrocytes exerted a functional influence on neuronal survival and may therefore influence regulation of glutamatergic neurotransmission in vivo.
-
Astrocytes Rescue Neuronal Health After Cisplatin Treatment Through Mitochondrial Transfer.
… <p>Astrocytes rescue neuronal health after cisplatin treatment through mitochondrial transfer.</p> <p>Author: Krystal English</p> <p>Advisory Professor: Dr. Cobi J. Heijnen, Ph.D.</p> <p>Chemotherapy-induced cognitive impairments are associated with neuronal …
-
Identification and characterization of a novel neurotrophic factor secreted by a mouse Schwann cell line
… in addition to their role as regulators of neuronal survival. Schwann cells are the major glial elements in the peripheral nervous system and, therefore, could play a major functional role in supporting neuronal differentiation and survival in nervous system. Here, we have characterized a …
-
Investigating protrudin’s role in neuroprotection and axon regeneration in the central nervous system
… — has previously been shown to strongly promote neuronal survival and axon regeneration after central nervous system (CNS) injury. This is in part due to increased levels of integrins in the distal axon, but this mechanism does not fully account for its beneficial effects. We have investigated …
-
Interactome Analysis Identifies Novel Targets of Phosphoinositide 3-kinase (PI3K) that Mediate Astrocyte Neuroprotection
In a homeostatic state, astrocytes can support neuronal survival and function through a range of secreted signals that protect against neurotoxicity, oxidative stress, and apoptotic cascades. Thus, the analysis of astrocyte conditioned media (ACM) may provide valuable insight into the nature of …
-
The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… neurons after injury suggests a role for CCR5 in neuronal survival after injury.
-
The Expression and Cellular Localization of Cc-Chemokine Receptor 5 (Ccr5) After Traumatic Brain Injury
… neurons after injury suggests a role for CCR5 in neuronal survival after injury.
Page 1 of 3