Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 5 of 5 for “"neuronal specification"”.
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Investigating the Transcriptional Regulation of PTF1A and the Function of PRDM13 to Specify Dorsal Spinal Interneurons
… is a fundamental process required for cell fate specification. During neural development, complex interactions of diverse transcription activators and repressors regulate lineage specific programs. The multitudes of neuronal subtypes generated during development is dependent on spatio-temporally …
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Prdm13, a Direct Downstream Target of Ptf1a, Regulates the Balance of Gabaergic Neurons versus Glutamatergic Neurons in the Dorsal Spinal Cord
… 3-5) and is required for the glutamatergic neuronal fate. In contrast, another bHLH factor Ptf1a, is restricted in progenitors to dI4 and is required to specify the GABAergic neuronal fate. Since progenitors to dI4 express both Ascl1 and Ptf1a, some mechanism must exist to repress Ascl1 …
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The role of <em>Pax7</em> in the formation of the superior colliculus and the vertebrate visual system
… of the superior colliculus, including neuron specification and differentiation, boundary formation, polarisation and retinocollicular mapping. By employing histochemical, immunohistochemical and immunofluorescent techniques, together with quantification utilising Optimas Digital Image …
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The role of Dichaete in transcriptional regulation during Drosophila embryonic development
… where they appear to play conserved roles in neuronal specification and differentiation. Despite years of detailed study we still have a relatively poor idea of how Sox proteins function on a genome wide scale and the aim of my PhD work was to explore this aspect using the fly group B protein, …
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Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2
… dopaminergic neurons. However, the mechanisms of specification of mesDA neurons in vivo need to be elucidated for identification and generation of mesencephalic dopaminergic (mesDA) neurons from stem cells in vitro. In this thesis I have identified expression of the proneural gene Neurogenin2 …