Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 78 for “"neuronal populations"”.
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Methods for Analyzing the Information Content of Large Neuronal Populations
… indicate that our method is scalable to large populations of neurons and has the capacity to efficiently identify biologically meaningful and informative low dimensional representations.
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Modeling phase synchronization of interacting neuronal populations : from phase reductions to collective behavior of oscillatory neural networks
… macroscopic dynamics when coupling two symmetric populations of phase oscillators. This setup is compared against a single network of oscillators whose frequencies are distributed according to a symmetric bimodal Lorentzian. Subsequently, I extend the applicability of the Ott-Antonsen ansatz to …
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Effect of Parkinson’s disease-related alpha-synuclein abnormalities on the maturation of distinct iPSC-derived neuronal populations
… Alpha-synuclein is primarily localised to neuronal presynaptic terminals and has been implicated in the maintenance of synaptic function. Studies have proposed that it regulates the docking, fusion, clustering and trafficking of neurotransmitter-loaded presynaptic vesicles. Nowadays, it is …
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Fast Neuronal Imaging using Objective Coupled Planar Illumination Microscopy
… by the brain are produced by activities of neuronal populations. There is a large diversity in the functions of each individual neuron, and neuronal activities occur in the time scale of milliseconds. In order to gain a fundamental understanding of the neuronal populations, one has to …
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Dopaminergic modulation of basolateral amygdala for fear extinction
… in driving fear extinction in distinct BLA neuronal populations. We identify sources of dopamine and modes of dopaminergic action in the BLA, by showing that BLA fear and reward neuronal populations receive topographically divergent inputs from VTA dopamine (DA) neurons and differentially …
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Selectivity for Movement Direction in the Human Brain
… object. Many neurophysiological studies reported neuronal populations selective for movement direction in many regions of the monkey brain. In my thesis, I investigated which areas in the human brain show directional selectivity. Moreover, I measured to what extent directional selective regions …
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Behavioral Responses to Methylphenidate: Correlations With Neuronal Activity In The Caudate Nucleus
… dose of MPH. Behavioral and caudate nucleus (CN) neuronal activity following acute and chronic doses of MPH was assessed by simultaneously recording the behavioral and neuronal activity. The experimental protocol lasted for 10 days using four groups; saline, 0.6, 2.5 and 10.0mg/kg MPH. Initially, …
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Unsupervised tracking and automated analysis of multi-population neural activity under anesthesia
… of how these volatile anesthetics affect the neuronal network activity and bring about the anesthetized state at the mesoscale, composed of hundreds of identified excitatory and inhibitory neurons. To address these issues, we developed a system that enables optical recording from multiple …
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Amygdala circuits underlying valence-specific behaviors
… Hence, the substrates, genetically distinct neuronal populations, for negative and positive behaviors are not known. The work presented here describes a genetically-defined amygdala circuit model for negative and positive behaviors. Development of a genetic-based circuit model of the amygdala …
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Transitioning Between Preparatory and Precisely Sequenced Neuronal Activity in Production of a Skilled Motor Behavior
… cell-type specific calcium imaging we identify populations of HVC premotor neurons associated with the beginning and ending of singing-related neural sequences. We characterize neurons that bookend singing-related sequences and neuronal populations that transition from sparse preparatory …
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Activity Based Profiling: New Insights into Metabolic Homeostasis
… that there are numerous unidentified neural populations that play a role in energy balance. Besides regulating caloric consumption and energy expenditure, neural components that control energy homeostasis are also tightly intertwined with circadian rhythmicity but this aspect has received …
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Neural prosthetics for paralysis : algorithms and low-power analog architectures for decoding neural signals
… to interpret patterns of electrical activity in neuronal populations in a real-time, on-line fashion. The system is primarily intended to enable the long-term implantation of low-power, microchip-based recording and decoding hardware in the brains of human patients in order to treat neurologic …
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The Neuroprotective and Therapeutic Effects of Anthocyanins and Their Metabolites In Vitro and in a Mouse Model of Amyotrophic Lateral Sclerosis
… (ALS) are characterized by the death of specific neuronal populations within the brain and spinal cord, leading to cognitive and/or motor impairment. While the etiology of many of these diseases is largely unknown, several factors have emerged as contributors to the neurodegenerative process. …
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Selective Neuronal Vulnerability in Neocortices from Patients with C9ORF72-related Neurodegeneration
… and that pathology likely extends to other neuronal populations (Chapter 1). This may be especially evident in patients with the hexanucleotide repeat expansion in the gene C9ORF72 (c9HRE): the most common genetic cause of both ALS and FTD. We hypothesise that in c9HRE-related …
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Investigating gene expression differences in acute and organotypic mouse hippocampal brain slices as models for studying the brain
… cells and a relative underrepresentation of neuronal populations. Notably, oligodendrocytes were almost exclusively found in OBSCs, while dentate progenitor cells were predominantly present in acute slices, reflecting ongoing developmental processes in culture. Differential gene expression …
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Tools for Mapping the Links Between Stimuli, AffectiveStates, and Behavior through Whole-Brain Imaging inZebrafish Larvae
… to observe neural activity across extensive neuronal populations. Genetically Encoded Calcium Indicators (GECIs) and Genetically Encoded Voltage Indicators (GEVIs) provide the means to probe brain dynamics with single-cell precision. The advent of lightsheet microscopy technologies has …
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The analysis of a mouse model of Lysosomal Storage Disorder uncovers a role for astrocyte dysfunction in neurodegeneration
… of cortical neurons in vivo, whereas other neuronal populations were spared. Furthermore, in an ex vivo co-culture assay, I observed that Sumf1<sup>-/-</sup> astrocytes failed to support the survival and function of wild type cortical neurons, suggesting a non-cell autonomous mechanism for …
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Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
… of gene expression in neurons, which underpins neuronal identity and information processing, has not been fully addressed. In this thesis, I present studies that demonstrate a potent yet previously unknown regulation of neuronal intrinsic excitability by the microRNA miR-128. I show using …
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Building an Allocentric Traveling-Direction Signal Via Vector Computation
… when walking sideways). We then characterize a neuronal circuit that rotates, scales, and adds four vectors related to the fly's egocentric traveling direction––the traveling angle referenced to the body––to compute the allocentric traveling direction. This circuit operates by mapping spatial …
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