Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 47 for “"neuronal plasticity"”.
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Neuronal plasticity in the enteric nervous system motor pathways
… increased excitability of enteric neurons. Thus, neuronal plasticity of the enteric nervous system is highly adaptable and able to compensate for inhibition of multiple receptors in peristaltic motor pathways.
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Effect of space conditions on neuronal plasticity and connectivity
… their specific and combined effects on in vitro neuronal network models. In vitro primary neuronal network cultures were established and exposed to simulated space conditions to investigate neuronal network remodelling (plasticity and connectivity) as well as genomic damage/repair dynamics. This …
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Intrinsic Neuronal Plasticity of Kiss1 Neurons in Mice around Puberty
… that Kiss1 neurons in the hypothalamus exhibit neuronal plasticity during puberty in mice. Kiss-CRE-tdTomato female mice begin puberty at around 4.5-5 weeks of age. Mice were divided into three age groups: 3-week pre-pubertal, 4-week pre-pubertal, and post-pubertal (6-8 weeks). To test their …
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CONSEQUENCES OF CHROMATIN MOSAICISM AND PERSISTENCE IN NEURONAL PLASTICITY AND DISEASE
… disorder, cell-type identities, and neuronal plasticity. In FXS, using imaging and genome-wide H3K9me3 profiling in patient-derived neural progenitor cells, I find that the mutation-length CGG expansion on the X chromosome drives inter-chromosomal clustering of heterochromatin domains …
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The Role of Nogo-A in Memory and Neuronal Plasticity in the Aged Rodent Brain
… Nogo-A plays a role in dendritic structural plasticity, and specifically the Nogo-A found in neurons, we used RNA interference to reduce the levels of Nogo-A in hippocampal CA1 pyramidal cells in aged rats. We did not detect any changes in dendritic spine density and morphology. Taken …
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Role of nitric oxide in neuronal plasticity in the mammal central and peripheral nervous systems
… la expresión de novo y/o sobre-expresión de NOS neuronal (nNOS) en las motoneuronas. Dado que el óxido nítrico (NO) participa en numerosos fenómenos de plasticidad sináptica, se podría sugerir un papel del NO en procesos de El principal objetivo de este estudio fue evaluar el papel del NO en la …
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Overexpression of Serum Response Factor in Astrocytes Improves Neuronal Plasticity in a Model of Fetal Alcohol Spectrum Disorders
Neuronal plasticity deficits underlie many of the neurobehavioral problems seen in Fetal Alcohol Spectrum Disorders (FASD). Recently, we showed that third trimester alcohol exposure lead to a persistent disruption in ocular dominance (OD) plasticity. For instance, few days of monocular deprivation …
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Inhibition of the Calcium Plateau Following In Vitro Status Epilepticus Prevents the Development of Spontaneous Recurrent Epileptiform Discharges
… and pathophysiologic changes leading to neuronal plasticity. The neuronal plasticity following SE-induced brain injury can initiate epileptogenesis and lead to the ultimate expression of acquired epilepsy (AE), characterized clinically by spontaneous, recurrent seizures. Epileptogenesis …
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Effetto della separazione materna sulla plasticità dei neuroni nell’ippocampo delle mamme e della prole
Neuronal plasticity is the capability of neurons to change the structure, function and organization of neurons in response to new experiences. Behavioral studies in rodents, have shown that changes in the environment, in different periods of life, can lead to profound and lasting effects on …
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Influence of Sodium Channel Activation on NMDA Receptor-Mediated Structural Plasticity.
Neuronal activity regulates morphology and connectivity of neurons during development. Many aspects of activity-dependent neuronal development such as dendritic arborization, spinogenesis and synaptogenesis are mediated via N-methyl D-aspartate receptor (NMDAR)-dependent signaling mechanisms. …
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The role of ras signaling associative learning and memory in Drosophila
… Recent studies also suggest roles of Ras in neuronal plasticity. I investigated the role of Ras in associative learning and memory in Drosophila. Flies carrying hypomorphic ras mutations were impaired in memory, with normal learning performance. The severity of the memory impairment …
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The role of neurogranin in modulating contextual memory and plasticity : FMRP involvement and adrenergic-dependent facilitation
Activity-dependent changes in neuronal properties (neuronal plasticity) are critical for information processing and storage in the brain. It is well-established that protein synthesis is essential for both memory formation and the long-lasting changes in synaptic strength that accompany learning. …
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La separazione dalla prole reverte le modificazioni nell'espressione di BDNF, proteina Arc, spine dendritiche, LTP e neurogenesi osservate durante la gravidanza e dopo il parto
… un mediatore chiave della plasticità neuronale e la sua azione a lungo termine ha un ruolo importante nell’apprendimento, memoria, comportamento affettivo ed emozionale (1); entrambi inoltre sono in grado di regolare l’architettura neuronale (2). Nel mio studio ho misurato le quantità …
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Activity-Dependent Plasticity in the Murine Olfactory Bulb Neurons
… the neural circuit. In sensory systems, adaptive neuronal plasticity is recruited to combat dynamic changes in sensory input – such as its sudden loss - and maintain circuit homeostasis. Adaptive neuronal plasticity can be induced and expressed at different cellular spatial scales, and is heavily …
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Synthesis of inhibitors of polysialyltransferases PST and STX. Development of routes to synthesis, preparation and purification of carbohydrate and carbacycle-based potential inhibitors of the polysialyltransferase enzymes PST and STX
… only in areas of the brain associated with neuronal plasticity. Significantly, a number of malignant tumours re-express polySia and there is considerable evidence that its presence is related to higher malignancy, invasion and metastasis. The hypothesis underpinning this project is that …
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Age-related impairments in memory and in cholinergic signaling due to reduced blood glucose responses to epinephrine
… are widely implicated in activity-dependent neuronal plasticity. Age-related deficits in brain glucose availability may limit these cholinergic signaling processes and produce memory impairments. This is the major hypothesis guiding these studies.
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On the neuronal processing of movement dynamics
… a kinematics-to-dynamics transformation. Neuronal correlates of that transformation are observed both at the level of the population and for single cells. 3. Extensive neuronal plasticity is observed in these areas when monkeys learn a new dynamics. The activity of single neurons modifies …
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Neural Plasticity and the Development of Intersensory Functioning in Bobwhite Quail (Colinus virginianus)
… constructing a link between early experience and neuronal plasticity, it has been established that unusual visual experience can produce measurable changes in post-synaptic structures, particularly dendritic morphology, in brain areas responsible for vision. In avian species, the brain area …
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Functional Redistribution of Hippocampal Cannabinoid Cb1 Receptors in the Rat Pilocarpine Model of Acquired Epilepsy
… represents an essentially permanent neuronal plasticity change associated with epileptogenesis, and could account for the anticonvulsant effect of cannabinoids observed in this model.
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Characterization and development of a stroke-induced model of acquired epilepsy in organotypic hippocampal slice cultures: role of the cannabinoid CB1 receptors in modulation of neuronal excitation and inhibition
… epilepsy provides a unique tool to study the neuronal plasticity changes associated with epileptogenesis. It also provides a practical model to study pharmacological agents that may be useful in preventing or treating epilepsy.
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