Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"neuronal nitric oxide synthase (nNOS)"”.
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Targeting Neuronal Nitric Oxide Synthase (nNOS) for Melanoma Treatment
… rates have continued to increase over the years. Neuronal nitric oxide synthase (nNOS) produces nitric oxide (NO) has been found to be overexpressed in human melanoma and the expression of nNOS is induced by interferon-gamma (IFN-γ). In our studies, nNOS has been implicated in IFN-γ-stimulated …
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Genetically encodable calcium sensors for Magnetic Resonance Imaging
… the hemodynamic response, which is coupled to neuronal activity through a calcium-activated enzyme, neuronal nitric oxide synthase (nNOS). We show that chemical stimulation of ectopically expressed neuronal nitric oxide synthase (nNOS) elicits an artificial hemodynamic response detectable by …
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Neuronal Nitric Oxide synthase regulates the expression of EAAT4 and GAD65/67 in the murine cerebellum
… fibers (PFs) that produce high levels of nitric oxide (NO) via neuronal nitric oxide synthase (nNOS). Previous studies demonstrate that nNOS/NO signaling is crucial for PF-PN synaptic transmission. This study sought to examine nNOS/NO signaling regulation of excitatory amino acid …
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Studies on the Synthesis and Rearrangement of Indazolylpyridinium Derivatives Precursors to Potential Neuroprotective Prodrugs Bearing a 1,2,3,6-Tetrahydropyridinyl Carrier
The neuronal nitric oxide synthase (nNOS) inhibitor 7-nitroindazole (7-NI) protects against the neurotoxicity of MPTP in a mouse model of neurodegeneration. Since 7-NI also inhibits the monoamine oxidase-B (MAO-B) catalyzed bioactivation of MPTP, the role of nNOS inhibition as a mediator of 7-NI's …
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Dissecting the signaling and mechanical functions of the dystrophin-glycoprotein complex in skeletal muscle
… Dp116 did not restore the signaling molecule neuronal nitric oxide synthase (nNOS) to the DGC, and specific parts of the dystrophin rod domain not found in utrophin were shown to participate in localization of nNOS. However, association of nNOS with the DGC was not required for amelioration of …
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A behavioural evaluation of the potential of nNOS inhibitors to control dyskinesia in animal models of Parkinson’s disease
… NMDA receptor activation is linked with nitric oxide (NO) production and changes in synaptic plasticity, suggesting a role in dyskinesia. This led to the hypothesis that NO, produced by neuronal nitric oxide synthase (nNOS), contributes to the occurrence and evolution of dyskinesia in PD. …
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Effects of nNOS Inhibitors on Melanoma-Induced Immunosuppression
… Our previous study suggests that neuronal nitric oxide synthase (nNOS)-mediated nitric oxide (NO) signaling is crucial for melanoma progression and forms a mechanistic rationale behind nNOS inhibition as a novel treatment strategy for CM. An additional study demonstrated that IFN-γ …
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A toxicological analysis of the cyanotoxin β-methylamino-L-alanine at multiple neural levels and identification of novel modes of activity
… disruption to mitochondrial activity and general neuronal death, indicate that the main mode of activity is via excitotoxic mechanisms. Data presented here indicate that BMAA induces increased intracellular Ca2+ influx, DNA damage, mitochondrial activity, lactate dehydrogenase (LDH) release and …
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A biochemical and molecular analysis of functional differences between dystrophin and utrophin
… was previously shown that utrophin cannot bind neuronal nitric oxide synthase (nNOS) even though dystrophin binds nNOS, establishing for the first time a functional difference between dystrophin and utrophin. Here, we show that transgenic overexpression of utrophin on the mdx mouse background …
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NMDAR-PSD95-nNOS Axis-Mediated Molecular Mechanisms in the Basolateral Amygdala Underlying Fear Consolidation
… (NMDARs). Stimulation of NMDARs recruits neuronal nitric oxide synthase (nNOS) to the synaptic scaffolding protein, postsynaptic density protein 95 (PSD95), to produce nitric oxide (NO). Our laboratory has previously shown that disruption of the PSD95-nNOS interaction attenuates fear …
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Il Δ9-THC, componente principale della cannabis sativa, attenua la neurotossicità indotta dalla meth
… and adverse consequences like activation of neuronal nitric oxide synthase (nNOS), production of peroxynitrite, microglia stimulation, astrogliosis and hyperthermia [Maxwell JC and Brecht ML, 2011]. Notably, METH abusers also consume Cannabis [UNODC, 2013]. Several line of research have …
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Development of Pharmaceutical Inhibitors Targeting nNOS for Melanoma Treatment
… our previous studies demonstrated that novel nNOS inhibitor HH044, effectively inhibited IFN-γ-induced PD-L1 expression both in vitro and in vivo. Another objective of this study was to determine whether nNOS-mediated nitric oxide (NO) signaling interacts with the COX-2-PGE2-PD-L1 signaling …