Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 87 for “"neuronal networks"”.
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Roles of gap junctions in neuronal networks
… the roles of gap junctions in the dynamics of neuronal networks in three distinct problems. First, we study the circumstances under which a network of excitable cells coupled by gap junctions exhibits sustained activity. We investigate how network connectivity and refractory length affect the …
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Tracking Light-Induced Synaptic Engrams in in-vitro Neuronal Networks
The concept that activity-dependent synaptic plasticity is at the core of learning and memory is a cornerstone of neuroscience. This intricate process entails synapses' capacity to adjust their strength in reaction to neural circuit activation, facilitating the nervous system's adaptation to …
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Emergence and stability of complex structures from stochastic neuronal networks
… of each neuron and the organization of the neuronal connections. Another way is from physiological study, which describes the specific electrical outputs of the cells. Computational studies have been developed to fill the gaps between these studies. There are several stochastic computational …
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Elastomeric Stamping: Design Considerations for Long -Term Maintenance of Neuronal Networks
This work describes the development of a technique for high-resolution patterning of proteins or biomolecules on glass substrates for the localization of neurons and their axons and dendrites. The new patterning process uses a microfabricated polydimethylsiloxane (PDMS) stamp with micrometer length …
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Unique applications of cultured neuronal networks in pharmacology, toxicology, and basic neuroscience
… research explored the capabilities of neuronal networks grown on substrate integrated microelectrode arrays in vitro with emphasis on utilizing such preparations in three specific application domains: pharmacology and drug development, biosensors and neurotoxicology, and the study of …
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Using feed-forward networks to infer the activity of feedback neuronal networks
… individual neurons which constitute different neuronal networks with distinct functions. In each network, constituent neurons are coupled with different connection patterns, for example, some neurons send feed-forward information to the coupling neurons while others are mutually coupled. …
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Understanding Neural Burst Patterns Through Graph Neural Network Explainability in Simulated Neuronal Networks
Spontaneous bursting activity in neural networks represents a fundamental mode of informationprocessing in the brain, yet the mechanisms triggering these synchronized events remain poorly understood. While graph-based representations of neural networks are established, discovering the specific …
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The role of short term synamptic plasticity in temporal coding of neuronal networks
Short term synaptic plasticity is a phenomenon which is commonly found in the central nervous system. It could contribute to functions of signal processing namely, temporal integration and coincidence detection by modulating the input synaptic strength. This dissertation has two parts. First we …
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Dynamics of phase locking in neuronal networks in the presence of synaptic plasticity
The behavior generated by neuronal networks depends on the phase relationships of its individual neurons. Observed phases result from the combined effects of individual cells and synaptic connections whose properties change dynamically. The properties of individual cells and synapses can often be …
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Technologies for and Electrophysiological Studies of Structured, Living, Neuronal Networks on Microelectrode Arrays
… action potentials. Their firing depended on neuronal communication as action potentials were suppressed by high magnesium media. In addition, we found that network activity depended on network morphology. Well-confined networks fired action potentials independent of cell density and varied …
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Examining the emergent properties of neuronal networks towards the creation of oscillatory biological machines
Made available in DSpace on 2018-03-13T17:28:55Z (GMT). No. of bitstreams: 2 LIU-DISSERTATION-2017.pdf: 6306728 bytes, checksum: 9cff0e840219845c90be2adfe5688a53 (MD5) LICENSE.txt: 4207 bytes, checksum: b44f37e1a190e4e9c44fe34c91f0ed34 (MD5) Previous issue date: 2017-08-10
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Determination of Dissociation Constants for GABAA Receptor Antagonists using Spontaneously Active Neuronal Networks in vitro
… activities recorded from murine frontal cortex networks grown on substrate-integrated microelectrodes were used to determine the dissociation constant (KB) of three GABAA antagonists. Neuronal networks were treated with fixed concentrations of GABAA antagonists and titrated with muscimol, a …
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Large-scale neuronal networks: from simulation technology to the study of plasticity-driven cognitive processes
… systems and the quest for simulating the neuronal dynamics has led to the development of several approaches and simulation tools able to represent the behavior of portions of the brain with different levels of detail. Among the different techniques that we can adopt to shed light on …
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Evaluation of Zinc Toxicity Using Neuronal Networks on Microelectrode Arrays: Response Quantification and Entry Pathway Analysis
Murine neuronal networks, derived from embryonic frontal cortex (FC) tissue grown on microelectrode arrays, were used to investigate zinc toxicity at concentrations ranging from 20 to 2000 mM total zinc acetate added to the culture medium. Continual multi-channel recording of spontaneous action …
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Investigating neuronal network dynamics : scale-invariance, preferred firing rates, and plasticity via phase-shift encoding
Understanding how neuronal networks process information and adapt to external stimuli is critical for advancing our knowledge of neural plasticity and computation. Scale-invariant properties, which suggest self-organised criticality (SOC), have been observed in these networks, but the mechanisms …
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Using avalanche statistics to forecast failure in models of earthquake faults and magnets
… as magnets, granular matter, earthquake faults, neuronal networks, and of course the classic example of snow flows on mountains. By studying the statistics of avalanche sizes, we can understand the response of such systems to external driving forces, as well and their susceptibility to …
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Statistical analysis of neuronal data: Development of quantitative frameworks and application to microelectrode array analysis and cell type classification
… for the analysis and classification of neuronal data from a variety of contexts. Firstly, I investigate methods for analysing spontaneous neuronal network activity recorded on microelectrode arrays (MEAs). I perform an unbiased evaluation of the existing techniques for detecting ‘bursts’ …
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Improved Fabrication and Quality Control of Substrate Integrated Microelectrode Arrays
Spontaneously active monolayer neuronal networks cultured on photoetched multimicroelectrode plates (MMEPs) offer great potential for use in studying neuronal networks. However, there are many problems associated with frequent, long-term use of MMEPs. The major problems include (1) polysiloxane …
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Characterization of Nitric Oxide Production in Single Neurons
… to behavioral roles and their underlying neuronal networks, we hope to discover the specific mechanisms by which NO exerts its influence over neurological functions.
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Two-photon calcium imaging sequence Analysis Pipeline : a method for analyzing neuronal network activity
Investigating the development of neuronal networks can help us to identify new therapies and treatments for conditions that affect the brain, such as autism and Alzheimer's disease. Two-photon calcium imaging has been a powerful tool for the investigation of the development of neuronal networks. …
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