Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 37 for “"neuronal morphology"”.
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Genetic analysis of the maintenance of neuronal morphology in Drosophila melanogaster
Precise control of cellular morphology is critical for both the development and maintenance of nervous systems. In the developing Drosophila eye, normal photoreceptor cells establish and maintain a highly polarized architecture, with cell bodies and nuclei located apically in the epithelium, and …
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The role of Ena/VASP and associated proteins in regulation of neuronal morphology and filopodia architecture
During central nervous system development cortical neurons extend a primary axon and multiple collateral branches to connect to numerous synaptic targets. While many guidance cues and their receptors have well-characterized roles in cortical axon guidance, the pathways that link these signals to …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… which is crucial for the functioning of neuronal circuits. Thus, understanding the cellular and molecular mechanisms leading to the precise assembly of neuronal circuits is a major focus of developmental neurobiology. The structural organization and specific connectivity of neuronal …
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The role of Synaptic Genes NRXN1 and SHANK3 in Autism: an induced pluripotent stem cell study
… with the structural or functional aspects of neuronal connections or synapses. However, it is poorly understood how the loss of function of these synaptic genes contribute to the neuronal morphology, network physiology and atypical communication between brain cells. This thesis aims to first …
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The Neurobiology of Motor Skill Learning: Structural Adaptation Within Sensorimotor Regions of the Rat Brain
… the animals received. Changes in synapse morphology were also observed in the AC animals that included significant increases in postsynaptic density (PSD) length, number of synapses with perforated PSDs as well as number of synapses forming multiple synaptic contacts. Finally, an …
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The role of the extracellular matrix in neuronal development and perinatal brain injury
… of ECM structures around neurons, termed perineuronal nets (PNNs). Although HA and PNNs are important for neuronal function in the mature brain, the specific expression and functions of HA and PNNs in the developing CNS under physiological and pathophysiological conditions remain largely …
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Microtubule Dynamics in Neuronal Morphogenesis
… (MTOCs) in neurons are not required as in non-neuronal cells. Assembly of microtubules within neurons is a major factor that affects neuronal morphology, and is regulated by tubulin availability and other nucleating factors. Maintenance of microtubules is determined in large part by …
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Intrinsic Features of the Multisensory Cortical Area LRSS in the Ferret
… and digital reconstruction to document neuronal morphology. Among the 90 reconstructed neurons, 4 distinct forms or pyramidal and 2 types of non-pyramidal neurons were found. Measurement of maximal dendritic spread indicates that a cortical column in the LRSS was 250.9 um in diameter. …
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Role of Laminin gamma 1 in Cortical Development
… the mechanisms underlying these abnormalities. Neuronal migration via the establishment of the radial glial scaffold and the Cajal-Retzius cell layer was affected in the mutants. Furthermore, axon pathfinding was impaired with developing axons projecting along the abnormally structured cortical …
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Characterising the role of GPR50 in neurodevelopment and lipid metabolism
… This thesis explores the role of GPR50 in neuronal development and lipid metabolism. The work presented in this thesis shows that GPR50 promotes neuronal differentiation. Overexpression significantly increased the number of neurites per cell in SH-SY5Y cells. Further, dendritic branching …
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The Impact of Insulin signalling on a C. elegans Alzheimer’s Disease Model
… Aβ exhibit phenotypes, including impaired neuronal morphology, decreased mobility, and reduced chemotactic responsiveness compared to wild-type counterparts. Remarkably, decreasing the insulin and insulin-like signalling (IIS) pathway via an insulin receptor daf-2(lf) mutation or expression …
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Investigating the Role of Insulin-Like Signaling in Paclitaxel-Induced Nociceptive Hypersensitivity using Drosophila melanogaster
… that this hypersensitivity precedes observable neuronal damage. At low concentrations, PTX caused hyper-sprouting of tertiary dendritic spines in peripheral nociceptors. At high concentrations, it caused dendritic degradation. We used this model of PTX-induced hypersensitivity to explore its …
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The retinoblastoma gene family in tumor suppression and development
… cells survived and differentiated into neuronal fates. Therefore, the role of Rb during development can be divided into a cell-autonomous function in exit from the cell cycle and a non-cell autonomous role in the suppression of apoptosis and induction of differentiation. Rb-/- ES cells …
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Neural Development to Neurodegeneration Through the Mind of a Worm
… of an organism. By examining mutations during neuronal development, we can better understand the significance of specific pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. elegans</em>, allow us to study the impact of EphR/ephrin …
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Automatic 3D Neuron Tracing from Optical Microscopy Images.
… the process of reconstructing three-dimensional morphology of neurons from microscopy images. It is essential for delivering more comprehensive understanding of the relationship between neuronal structure and function, which is the fundamental to know how the brain works. However, currently …
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Regulation of Microtubules by Patronin within Drosophila Dendrites
… as a model to forward our understanding on neuronal development and maintenance. Neurons are the most modular of all cells, comprising of a cell body, axon and dendrites. The development and function of each compartment relies heavily on the cytoskeleton, a major component of which are …
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RNA Dysregulation in a Novel Human Model of TDP43 Proteinopathy
… mis-splicing. This includes the three neuronally enriched proteins ACTL6B, ELAVL3, and CELF5. Utilising shRNAs, we independently knocked down these transcripts in healthy MNs to investigate their impact on neuronal morphology and the transcriptome. Depletion of ACTL6B profoundly reduced …
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The Neurogenic Capacity of Müller Glia and Synaptic Remodeling in the Mammalian Retina: Implications for Regenerative Therapies
… a subset of Müller glia acquired a more neuronal morphology and expressed neuronal genes. To determine the role of environment on Müller glia derived neurogenesis, Müller glia were cultured in three dimensional (3D) peptide hydrogels. Cells encapsulated within 3D hydrogels expressed …
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Induction and Inhibition of a Neuronal Phenotype in Spodoptera Frugiperda (Sf21) Insect Cells
… the growth medium, Sf21 cells began to express neuronal morphology, or the production of elongated, axon-like processes within 2-3 days. Maximal differentiation occurred when in the presence of 42 μM 20-HE or 10 μM insulin. Effects were maximal on day 2 for 20-E and day 3 for insulin. Insulin …
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