Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 33 for “"neuronal migration"”.
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PRC2 GATEKEEPS THE BALANCE BETWEEN DIRECT AND INDIRECT NEUROGENESIS AND CONTROLS NEURONAL MIGRATION DURING HUMAN CORTICOGENESIS
… These analyses revealed disruptions in neuronal maturation and migration processes from day 25 to 250 of differentiation. We observed temporally regulated gene expression defects and asynchronous cell type emergence in WVS, particularly affecting indirect neurogenesis. By identifying …
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Identifiying Casc15 as a novel regulator of progenitors’ proliferation and neuronal migration in the developing neocortex
… von neuraler Stammzellproliferation und neuronaler Migration identifiziert. Überexpression von Casc15 im entwickelnden Kortex verursachte eine Deregulierung von Genen, die in der Entwicklung des Nervensystems und Zellteil-Morphogenese involviert sind. Insbesondere herunterregulierte Gene …
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Characterization and Functional Analysis of Astrotactin 2 Reveals a Role for Endocytosis in Glial-guided Neuronal Migration
… and Purkinje cells, develops by glial-guided migrations that position these cell types in specific neuronal layers. Classical EM studies and real time imaging of the migration of granule neurons along glial fibers established the mode of movement of migrating neurons, including the formation …
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Genetic analysis of novel regulators of neuronal migration in Caenorhabditis elegans: the insulin/IGF-1 signaling pathway, a chromatin-binding factor ZFP-1 (AF10) and endogenous RNAi
… of functional neural circuitries requires neuronal migration, a central component of proper nervous system development. When defective, it can lead to devastating conditions including epilepsy and mental retardation. In the nematode C. elegans, neurons undergo both short- and long-range …
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HEM-protein regulates cell migration and asymmetric cell division during development of the ventral nerve cord in Drosophila melanogaster
Cell migration and asymmetric cell division are two of the key events during development of the nervous system. I have focused on a typical neuronal lineage, NB4-2→GMC-1→RP2/sib, in the ventral nerve cord (VNC) of the Drosophila embryo to investigate the regulation of neuronal migration and …
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The Brain Invaders: Widespread Neuronal Dispersion in Developing and Adult Mammalian Brain
<p>Cell migration is the principal determinant of the final brain cytoarchitecture. However, we have only limited knowledge about the migratory pathways and mechanisms utilized during brain development. In my thesis I present new and unexpected findings about neuronal migration in the developing …
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The Nrg Growth Factors and Their Receptor ErbB4 in the Developing Brain: Delineation of Nrg3 Expression and Neuritogenesis
… and roles in polarity-driven events such as neuronal migration and the establishment of radial glial morphology. Due to the roles of Nrg-ErbB pairs in the healthy and malignant brain, the aims of this thesis were to address fundamental gaps in knowledge and to expand on the roles of the Nrgs …
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Microtubule Dynamics in Neuronal Morphogenesis
… (MTOCs) in neurons are not required as in non-neuronal cells. Assembly of microtubules within neurons is a major factor that affects neuronal morphology, and is regulated by tubulin availability and other nucleating factors. Maintenance of microtubules is determined in large part by …
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Role of Laminin gamma 1 in Cortical Development
… the mechanisms underlying these abnormalities. Neuronal migration via the establishment of the radial glial scaffold and the Cajal-Retzius cell layer was affected in the mutants. Furthermore, axon pathfinding was impaired with developing axons projecting along the abnormally structured cortical …
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A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout defines neuronal and non-neuronal functions in mouse development
… systems. While the characterization of extra-neuronal functions of ligands and receptors has emerged, the conservation of intracellular signaling pathways remains unclear. The Ena/VASP protein family is a common downstream effector of multiple axon guidance signaling cascades. The analysis of …
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The Effects of PTEN Deletion on Cell Size and Plasticity in the Hippocampus
… the PI3K pathway modulates proliferation, migration, cellular size and synaptic transmission and plasticity. Neurologic abnormalities such as autism, seizures, and ataxia are associated with inherited PTEN mutations. Yet, how PTEN loss contributes to neurologic dysfunction remains unknown. …
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Expression of Apolipoprotein E Receptor 2 (ApoER2) and Very Low Density Lipoprotein Receptor (VLDLR), Reelin Receptors in Development of Cerebellar Cortex
… an extracellular matrix protein regulates neuronal migration in the cerebral cortex, hippocampus, cerebellum and many other regions of mammalian brain. In the cortex, reelin is secreted by cajal-Retzius cells in the developing marginal zone and is required for inside-out layering of neurons …
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Dissecting the Development and Function of C. elegans Glia with Mutations of the mls-2 and vab-3 Genes
… roles in a variety of processes including neuronal migration, synaptogenesis, and modulation of synaptic activity. Yet, many aspects of glia-neuron interactions remain obscure partly because manipulation of glia can result in neuronal death, hampering attempts to study glial cells in vivo. …
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Discovery of the novel mouFSnrp gene and the characterisation of its in situ expression profile during mouse neurogenesis
… have been previously shown to act as potent neuronal chemoattractants and have a major role in neural regeneration. In light of these properties, these peptides are key candidates for drug development against an array of neurodegenerative disorders. The aim of this PhD project was to provide …
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Roles of Myocardin-Related Transcription Factors in Muscle and Brain
… contexts, particularly during cardiovascular and neuronal development. This dissertation aims at studying the in vivo relevance of the partnership between Serum response Factor (SRF) and its Myocardin Related Transcription Factor (MRTF) coactivators during development. I present here my studies on …
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Regulation and Function of Apoer2 and Vidlr in the Central Nervous and Reproductive Systems
… Reelin signaling pathway. This pathway controls neuronal migration and organization of the brain during development as well as synaptic function in adulthood. Although both receptors partially compensate for one another during Reelin signaling, the generation of knockin mutant animals has allowed …
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The crucial role of reelin in a preclinical model of depression
… in stimulating the growth of dendrites, guiding neuronal migration, and regulating synaptogenesis. The goal of these experiments was to investigate the involvement of reelin in depression using the CORT model. In the first experiment, reelin downregulation in an animal model of recurrent …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… a detailed characterization of neuroblast migration along their associate substrates in the piglet cortex under normal physiological conditions and how reduced oxygenation (i.e., hypoxia) can impact their vulnerability and/or resistance to injury during a critical period of postnatal …
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BRAIN ORGANOIDS AS MODELLING CONDUITS OF HUMAN NEURODIVERSITY: ADVANCED COMPUTATIONAL APPROACHES TO SINGLE CELL TRANSCRIPTOMICS
… design to explore interindividual variability in neuronal migration, a process that is particularly relevant to cortical expansion and layering. Moreover, to tackle the need for more granular modelling capabilities, I mapped the SC transcriptional diversity of polarized cortical assembloids …
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Characterizing and Treating The Neuropathology of Tuberous Sclerosis Complex In The Mouse
… megalencephaly, enlarged neurons, abnormal neuronal migration, altered progenitor pools, hypomyelination, and an astrogliosis. The similarity of these defects to those of TSC patients establishes this mouse as an excellent model for the study of the neuropathology of TSC and testing novel …
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