Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 83 for “"neuronal loss"”.
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Evaluating The Estimation of Neuronal Loss in Glaucoma
PURPOSE: In vivo imaging with optical coherence tomography (OCT) is widely used in the diagnosis and monitoring of glaucoma and other optic neuropathies. With spectral domain OCT (SD OCT), cross-sectional images of the retinal nerve fiber layer (RNFL), optic nerve head (ONH) and the macula can be …
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Investigating the effects of calreticulin and beta-galactosidase on microglial functions and neuronal loss
… I investigated how microglial functions and neuronal loss were affected by calreticulin and β-galactosidase, two proteins associated with ageing, chronic inflammation, and neurodegeneration. The aggregation of amyloid-β to form oligomers and insoluble amyloid plaques in the brain is a …
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Investigating the effects of TREM2, APOE and PILRα variants on microglial functions and neuronal loss
… APOE and PILRα in microglial functions and neuronal loss. Triggering receptor on myeloid cells 2 (TREM2) is an innate immune receptor, primarily expressed by microglia in the CNS and upregulated on the surface of microglia associated with amyloid plaques in AD. Individuals heterozygous for …
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The Role of Astrocyte Activation in Infantile Neuronal Ceroid Lipofuscinosis
Infantile neuronal ceroid lipofuscinoses: INCLs), or Batten Disease, is an inherited neurodegenerative lysosomal storage disorder affecting the central nervous system: CNS) during infancy or childhood. Hallmark pathological changes include accumulation of autofluorescent material, neuronal loss, …
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Noise-induced cochlear neuronal degeneration and its role in hyperacusis -- and tinnitus-like behavior
… Here we ask whether this noise-induced primary neuronal degeneration results in abnormal auditory behavior, indexed by the acoustic startle response and prepulse inhibition (PPI) of startle. Responses to tones and to broadband noise were measured in mice exposed either to a neuropathic exposure …
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The molecular mechanism of Dual leucine zipper kinase protein localization in neuronal stress signaling.
… within neurons is essential for maintaining neuronal homeostasis. Certain proteins exhibit notable enrichment in axon terminals, where they exert pivotal influences on neuronal function, morphology, and survival. Dual Leucine Zipper Kinase (DLK) modulates neuronal stress responses, including …
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The Role of Fractalkine-mediated Neuroprotection in the Diabetic Retina
… worldwide due to hallmarks that include neuronal loss, microgliosis, and vasculature damage. Evidence suggests neurodegeneration and neuronal loss precedes vascular dysfunction in early diabetes. Inflammation caused by microglia exacerbates retinal pathology. Microglia, the resident …
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Adapt, Survive or Die - Metabolic Imbalances and the Enteric Nervous System
… fat diet (HFD) for 6 months have a significant loss of enteric neurons. To evaluate metabolic factors known to be altered in the obese/T2D-condition (ODC), we used isolated enteric neurons. We noted that palmitic acid (PA), a lipid known to be increased in ODC caused a significant loss of …
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Pro-oxidative and Pro-inflammatory Mechanisms of Brain Injury in Experimental Animal and 3D Cell Culture Model Systems
… pro-inflammatory environments in the brain and neuronal loss with adverse behavioral outcome. The results provide evidence that pro-oxidative and pro-inflammatory environments in the brain could play a potential role in blast-induced neuronal loss and behavioral deficits. In the second study, we …
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Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila
… disorder caused by the selective loss of the dopaminergic neurons in the <em>S</em><em>ubstantia nigra</em><em> pars compacta</em> region of the brain. PD is also the most common neurodegenerative disorder and the second most common movement disorder. PD patients exhibit the …
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Neuroinflammation in Alzheimer’s Disease Mouse Brain Following Repetitive Mild Traumatic Brain Injury
… of specific receptors (e.g., TREM2) and neuronal loss can better illustrate the role of glial cells.</p>
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
… in the deterioration of myelin sheaths and neuronal injury. For reasons that remain unclear, the majority of patients eventually enter a disease stage termed progressive MS (PMS), which is characterised by a substantial failure of the main endogenous brain repair mechanism seen in the early …
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Investigation of hypothalamic molecular mechanisms underlying narcolepsy and obesity through DNMT1 and leptin receptor signalling
… neurons that regulate sleep, also induce neuronal loss when introduced into mice. No evidence was found for the loss of sleep-regulatory hypocretin neurons in Dnmt1 mutant mice. The second project used proximity proteomic methods to identify proteins that regulate human leptin receptor …
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Regulation of neuronal genomic integrity through histone deacetylase cooperativity
… two lysine deacetylases, SIRT1 and HDAC1, in the neuronal response to DNA double strand breaks (DSBs). Both SIRT1 and HDAC1 were previously shown to promote neuronal survival in a mouse model of neurodegeneration in which the appearance of DSBs precedes other neurotoxic symptoms. Here I show for …
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MODELLING GBA1-RELATED PARKINSON¿S DISEASE PATHOLOGY IN PATIENT-DERIVED MIDBRAIN ORGANOIDS
… bodies” and “Lewy neurites” and dopaminergic neuronal loss in the nigrostriatal system are the key neuropathological hallmarks of Parkinson’s disease. Mutations in GBA1, encoding the glucosylceramide-hydrolyzing enzyme glucocerebrosidase, cause Gaucher’s disease and are the most frequent …
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Profiling hotspots of DNA breaks and learning-induced gene expression in the mouse brain
Neuronal activity generates DNA double-strand breaks (DSBs) in the brain. Topoisomerase IIb (TOP2B), important for relieving transcription-associated DNA supercoiling, was implicated as the source of these neuronal activity-induced DSBs, facilitating rapid transcriptional induction of immediate …
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The analysis of a mouse model of Lysosomal Storage Disorder uncovers a role for astrocyte dysfunction in neurodegeneration
… of cortical neurons in vivo, whereas other neuronal populations were spared. Furthermore, in an ex vivo co-culture assay, I observed that Sumf1<sup>-/-</sup> astrocytes failed to support the survival and function of wild type cortical neurons, suggesting a non-cell autonomous mechanism for …
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Studying Microglia-Mediated Neurodegeneration Using Cocultures
… microglial phagocytosis and inflammation control neuronal function and survival. Some microglial activity may be beneficial during neurodegeneration, but excessive release of pro-inflammatory cytokines and reactive oxygen/nitrogen species is a hallmark of neurodegenerative disease and can promote …
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The Effect of Chronic Hypertension on Neuropathology in the TGSWDI Mouse Model of Alzheimer's Disease
… blood brain barrier leakage, and pericyte loss in these mice. Though lysosomal markers were increased in hypertensive TgSwDI mice relative to all other groups, autophagic structures appeared to be increased in both hypertensive TgSwDI mice, as well as hypertensive WT mice. The increased …
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Energy failure following traumatic brain injury: Potential mechanisms and impact of normobaric hyperoxia
… of classical ischaemia may represent ongoing neuronal dysfunction and progressive neuronal loss. Any therapeutic intervention that mitigates such metabolic derangements before they result in irreversible neuronal injury may improve tissue fate and improve the functional outcome for patients. …
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