Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 9 of 9 for “"neuronal identity"”.
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The Flexible Mind of a Worm: the atlas of brain-wide representations of behavior in C. elegans
… encode distinct behavioral features. Utilizing neuronal identity information of the recorded neurons, we created the first-ever atlas describing how each defined neuron class in an animal’s brain encodes its behavior. Furthermore, we examined how these encodings change over varying behavioral …
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Small Molecules Modulate Chromatin Accessibility to Promote NEUROG2-Mediated Fibroblast-to-Neuron Reprogramming
… events that initiate an acquisition of neuronal identity in fetal human fibroblasts. NEUROG2 immediately activates a neurogenic program, but is only sufficient to impart a functional identity in the presence of FD. These small molecules promote NEUROG2 and CREB1 co-transcription, induce …
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Tuning of Neuronal Excitation by a Brain Specific Microrna MIR-128: From Targets to Behavior
… of gene expression in neurons, which underpins neuronal identity and information processing, has not been fully addressed. In this thesis, I present studies that demonstrate a potent yet previously unknown regulation of neuronal intrinsic excitability by the microRNA miR-128. I show using …
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Regulation of neuronal differentiation by activity-induced calcium influx in striatal neural precursors
Neuronal activity induces Ca2+ influx that regulates neurogenesis and distinct aspects of neuronal differentiation in the embryonic and adult brain. This thesis focusses on the regulation of neuronal differentiation in striatal neural precursors (NPCs) by activity induced Ca2+ influx. Neurons …
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Transcriptional Regulation of Neuronal Differentiation in the Drosophila Central Nervous System
… thesis research has focused on the generation of neuronal diversity: specifically how neurons adopt individual, often unique, identities. Work in many labs has revealed that a large set of transcription factors act in combinatorial manner to specify the fate of individual neurons or small groups …
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Low-rank graphical models and Bayesian inference in the statistical analysis of noisy neural data
… and measure information loss in analysis of neuronal spike train data due to two types of noise, making use of the ideas developed in the first part. Information about neuronal identity or temporal resolution may be lost during spike detection and sorting, or precision of spike times may be …
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Mechanisms for Maintaining Cell Identity in C.elegans Olfactory Neurons
<p>Maintenance of cell identity is a complex process that depends on developmentally determined transcriptional states and on environmental input. In neurons, which are both highly differentiated and highly sensitive to external stimuli, maintenance of identity is especially challenging. In this …
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Transcriptional profiling of Drosophila larval ventral nervous system hemilineages
… in the adult CNS of Drosophila are born from neuronal stem cells (neuroblasts) during the post-embryonic phase of neurogenesis. Most of the post-embryonic neurons derive from type I neuroblasts, which undergo repeated asymmetric divisions to produce a series of ganglion mother cells (GMCs). …
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Uncovering the role of notch signaling in development of hypothalamic nuclei in vivo and using in vitro microenvironments
… homeostasis, as while NICD tg mice showed no neuronal differentiation, Rbpj cKO mice showed significantly more of both Pomc or NPY neurons involved in feeding. Follow-up studies established that this observation was not due to differences in the timing of development of neurons involved in …