Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 4 of 4 for “"neuronal guidance"”.
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LATE PROTECTIVE EFFECTS OF NETRIN-1 AND ADENOSINE A2B RECEPTOR ACTIVATION IN THE MURINE ACETAMINOPHEN HEPATOTOXICITY MODEL
… late acting therapeutic options are needed. The neuronal guidance cue netrin-1 has been shown to promote hepatic repair and regeneration during liver ischemia/reperfusion injury, but its effects in APAP hepatotoxicity is unknown. The primary objective of this dissertation was to explore the role …
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Endogenous Mechanisms Regulating Myeloid Cell Mediated Inflammation During Acute Lung Injuries
… In the second approach, we demonstrate that the neuronal guidance protein, Netrin-1, is highly expressed in infiltrating alveolar macrophages after the onset of ALI. Netrin-1 deletion in the myeloid compartment resulted in exacerbated ALI and increased NK cell recruitment, which was dependent on …
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Piezo1-dependent mechanical regulation of chemical signalling in the developing Xenopus laevis brain
… how tissue stiffness and longrange chemical guidance cues interact, using the developing Xenopus laevis forebrain as a model system. First, I adapted hybridisation chain reaction RNA fluorescence in situ hybridisation (HCR RNA-FISH) to Xenopus laevis brains. I then probed the expression of …
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Dissecting the Development and Function of C. elegans Glia with Mutations of the mls-2 and vab-3 Genes
… roles in a variety of processes including neuronal migration, synaptogenesis, and modulation of synaptic activity. Yet, many aspects of glia-neuron interactions remain obscure partly because manipulation of glia can result in neuronal death, hampering attempts to study glial cells in vivo. …