Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 19 of 19 for “"neuronal functions"”.
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A lentiviral system for RNAi transgenesis and the Ena/VASP triple-knockout defines neuronal and non-neuronal functions in mouse development
… systems. While the characterization of extra-neuronal functions of ligands and receptors has emerged, the conservation of intracellular signaling pathways remains unclear. The Ena/VASP protein family is a common downstream effector of multiple axon guidance signaling cascades. The analysis of …
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Deconvoluting Cell-Type Specific 3'UTR Isoform Expression in the Adult and Developing Cerebellum
… these comparisons, many were involved in key neuronal functions. We further characterize one such transcript, Memo1, which changed poly(A) site usage during granule cell development, and was concomitantly downregulated. We show that miR-124 specifically targets the long isoform of Memo1, which …
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TTBK2 and Primary Cilia are Required for Purkinje Cell Survival
… of Ttbk2 both in ciliary biology as well as it’s neuronal functions. Using various genetic mouse models, I have found new roles for Ttbk2 in cilium stability and function that may help explain in part the etiology of SCA11. I then go on to further characterize the roles for primary cilia in …
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Computational models of neuronal fear and addiction circuits
… tools to abstract and generalize principles of neuronal functions using mathematics, with applicability to the entire neuroscience spectrum. Subcircuits related to fear and addiction are considered at three levels, network, cellular and intracellular levels. In the area of fear learning, we …
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Are Post-Transcriptional RNA Modification Events in the Glutamate-Gated and GABA-Gated Chloride Channels of Anopheles minimus and Anopheles dirus associated with Ivermectin Insensitivity?
… mosquitoes by having a detrimental effect on neuronal functions by acting on the glutamate-gated (GluCl) and the GABA-gated (RDL) chloride channels. The mechanism by which this is achieved is poorly understood. Using a combination of molecular and bioinformatic techniques such as DNA/RNA …
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Role of Drosophila Rap/Fzr (Cdh1) in retinal axon targeting and its interactions with Loco, Liprin-a and Ras
… and GAL4-UAS techniques show that Rap/Fzr functions in a cell autonomous manner. To test for possible role of other signaling molecules and interactions with Rap/Fzr, we have examined rap phenotypes in double mutant combinations with Loco, Liprin-α, and RasV12 mutants. Our studies suggest …
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Novel Functions for Neuronal RNA Processing Bodies in the Control of Axon Terminal Growth in Drosophila Melanogaster
<p>In this thesis we first characterized neuronal functions for HPat/Pat1, a core component of RNA processing bodies or "P bodies". We show that <em>hpat</em> mutants exhibit a strong synaptic hyperplasia at the developing and acutely stimulated <em>Drosophila</em> larval neuromuscular junctions …
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Signaling Mechanisms That Control Gap Junctional Coupling Between Retinal Neurons
… non-mammalian ortholog connexin 35) is the major neuronal gap junction protein in the central nervous system (CNS), and contributes to several important neuronal functions including neuronal synchronization, signal averaging, network oscillations, and motor learning. Connexin 36 is strongly …
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Severely Stressed Astrocytes Adapt to Injury and Still Protect Neighboring Neurons
… role in brain homeostasis by supporting neuronal functions. Therefore, one of the major goals of the present study was to identify ways to reduce the impact of proteotoxicity in astrocytes. In Aim 1, we examined natural adaptations to proteotoxic stress in astrocytes. Our studies …
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Analysis of miRNome expression profile in hippocampus of rats treated with antidepressants
… are involved in several pathways related to neuronal functions and ADs mechanism of action; moreover, many of the putative target genes, in particular those of miRs modulated by agomelatine, are enriched in pathways related to DNA/RNA regulation and epigenetic mechanisms. A number of putative …
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Molecular tuning of a neural circuit that drives aggregation behaviour in C. elegans
… sustains escape of 21% O2, we identify novel neuronal functions for several highly conserved genes, including a caspase-like molecule, a calcium-sensitive transcription factor, and two translation initiation factors. These molecules have been implicated in diverse forms of human disease, but …
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A Novel Switch-Like Function of Delta-Catenin In Dendrite Development
<p>The formation of neuronal networks in the brain is tightly regulated, and dependent on the morphology of dendrites, the branch-like signal-receiving structures extending from neurons. Disruptions in dendrite development, or dendritogenesis, can lead to the atypical neuronal connectivity …
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LNX1 and LNX2 in the central nervous system: linking behavioural, cellular and molecular perspectives
… of E3 ubiquitin ligases with emerging roles in neuronal development and function. In the central nervous system, LNX1p70/p62 isoforms and LNX2 show dynamic expression during development, with nearly undetectable protein abundance in the adult brain, making them notoriously difficult to study. …
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Evaluation of Computational and Experimental Parameters in RNA Bisulfite Sequencing Analysis and Applications in Brain Development Studies
… and differentiation, brain development, and neuronal functions. While we are just beginning to understand the functions of m5C, a gold standard of m5C detection has yet to be established due to the low signal-to-noise presence of m5C. In this work, we utilize RNA bisulfite sequencing as a …
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THE INTERPLAY BETWEEN HPCAL4 AND MECP2: IDENTIFICATION AND CHARACTERIZATION OF A NOVEL PUTATIVE TARGET FOR RETT SYNDROME THERAPY
… abundant in brain and important for proper neuronal maturation and function. In fact, MeCP2 deficiency in neurons is responsible for impairment of fundamental aspects of neuronal development and function including defects in dendritic arborization and spine density. Besides Mecp2, several …
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Reassessing the role of Cyclin-dependent kinase 5 in tumourigenesis
… <br/><br/>Cdk5 is heavily depicted as a neuronal-specific kinase, due to its association with neuronal activators, and dysregulation of Cdk5 activity is thought to contribute to the pathogenesis of several neurodegenerative diseases, including Alzheimer’s disease. Nonetheless, the …
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THE ROLE OF HSF1 PROTEIN REGULATION ON NEURODEGENERATION
… gene exhibited deficits in hippocampal-dependent functions including short-term working memory, spatial learning and long-term memory. All together, our work supports a previously underappreciated importance of this master stress regulator HSF1 in neuronal functions and in maintaining brain …
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The Association Between Traumatic Brain Injury and Alzheimer's Disease: Mouse Models and Potential Mechanisms
… characterized pathologically by progressive neuronal loss, extracellular plaques containing the amyloid-β: Aβ) peptides, and neurofibrillary tangles: NFTs) composed of hyperphosphorylated tau proteins. Aβ is thought to act upstream of tau, affecting its phosphorylation and therefore …
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C.elegans locomotion: an integrated approach
… but simplified to a set of repeating units. Neuronal properties are modelled at different levels of abstraction, with a proof-of-concept continuous model that is used to ground assumptions in physiological data, and a simplified binary model that is then used to study the locomotion control …