Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 76 for “"neuronal function"”.
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Impaired N-Glycosylation Processing Impacts Neuronal Function
… and post-translationally modify protein function by the addition and processing of oligosaccharides. These oligosaccharides are known as glycans and are broken up into three types: oligomannose, hybrid and complex. Modification of oligosaccharides is performed by enzymes known as …
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Precise optical manipulation techniques for exploring neuronal function
… manipulating neurons in the analysis of their function, namely time-gated holographic two-photon photostimulation and femtosecond laser dendrotomy. At the start of this thesis, no illumination technique had been able to activate synapses along the three-dimensional (3D) dendritic arbour of a …
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Precise optical manipulation techniques for exploring neuronal function
… manipulating neurons in the analysis of their function, namely time-gated holographic two-photon photostimulation and femtosecond laser dendrotomy. At the start of this thesis, no illumination technique had been able to activate synapses along the three-dimensional (3D) dendritic arbour of a …
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Exploring the influence of adipokines on neuronal function in Alzheimer’s disease
… impairment and amyloid-β plaques and intraneuronal neurofibrillary tangles are the characteristic pathology of AD. Studies have shown that obesity is major risk factor in Alzheimer’s disease. While obesity related modulation has been suggested to influence AD pathogenesis, the molecular …
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Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches
All nervous system functions, ranging from simple reflexes to complex behaviors and learning and memory, rely on networks of interconnected brain cells called neurons. Loss of various neuronal circuit functions, due either to stroke, epilepsy, trauma, Parkinson's, Alzheimer's or neurodegenerative …
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RADIATION-INDUCED BRAIN INJURY: NOT JUST A MICROGLIA AND HIPPOCAMPUS STORY ANYMORE
… microglia-mediated neuroinflammation and altered neuronal function are hypothesized to play a role. However, cognitive studies with renin-angiotensin system (RAS) blockers which increase Ang-(1-7), indicate that microglia and the hippocampus may not be the complete story. Thus, we hypothesized …
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Modulatory effects of GluN1 autoantibodies on brain function
… central nervous system (CNS) to modulate brain function, as supported by findings in vaccination strategies for Alzheimer’s disease (AD) in mouse models and autoimmune disease models. Our laboratory has previously shown that naïve rats vaccinated against the GluN1 subunit of the …
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Mechanisms Mediating Adaptive Presynaptic Muting Induction
… the nervous system, so strong perturbations of neuronal function have far-reaching consequences within the neural network. Damage in response to excess excitation, as occurs during stroke or seizure, is known as excitotoxicity. One method utilized by neurons for reducing excitotoxicity within an …
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Fragile X Mental Retardation Protein Induces Synapse Loss Through Acute Postsynaptic Translational Regulation
… The root cause of FXS is loss of the function of a single protein: the Fragile X Mental Retardation Protein (FMRP). FMRP is an RNA-binding protein that plays a complex role in translational regulation. FMRP may be an important regulator of dendritic protein synthesis, which occurs at …
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A multi-photon microscope for three dimensional functional recording of fast neuronal activity
… limitations complicate any attempt to study neuronal function with sub-cellular resolution: First, neurons and neuronal processes are small, second, in realistic experimental situations they can be located deep within optically scattering tissue, third, the chemical and electrical signaling …
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The gut-brain axis in seizure susceptibility: A role for microbial metabolite S-equol
… characterize the effect of exogenous S-equol on neuronal function in vitro, demonstrating a reduction in neuronal excitation following S-equol exposure. We additionally characterize entorhinal cortex (ECTX) pyramidal neuronal hyperexcitability, and demonstrate the ability of exogenous S-equol to …
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CANNABINOID RECEPTOR INTERACTING PROTEIN 1A (CRIP1A): EFFECTS ON CB1 RECEPTOR FUNCTION AND CELLULAR REGULATION
… CB1R, and has been shown to alter CB1R-mediated neuronal function. The mechanisms by which CRIP1a regulates CB1R activity and trafficking have not yet been identified; therefore the focus of this dissertation is to examine the cellular effects of CRIP1a on CB1R function and cellular trafficking.
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Learning and cemory in the cav1.2 knockout mouse
… (L-VGCCs) is involved in numerous aspects of neuronal function: activation and regulation of gene transcription, synaptic plasticity, and regulation of neuronal excitability are all modulated by calcium. Because many calcium-related subcellular functions are implicated in the formation and …
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Understanding Neuronal Autophagic Lysosomal Pathways Through Genetic and Pharmacological Perturbations
… of disrupting axonal lysosomal transport on neuronal autophagy has not yet been fully elucidated. In this thesis, we address both questions and, in the process, further contextualize the role of JIP3 in overall neuronal function. We found that JIP3 is critical for preventing accumulation of …
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Mechanisms of Calcium Buffering and Aging in Neurons: Testing the Limits of Homeostasis
… messenger that integrates multiple and diverse neuronal pathways that include development and maturation, gene expression, synaptic plasticity, transmitter release, excitability, and even cell death. Upon neuronal excitation the [Ca<sup>2+</sup>]i increases rapidly and the calcium buffering …
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Molecular recognition of chlorine-doped polypyrrole
The objective of this work is to functionalize an existing polymer such that it better mimics natural tissue for tissue growth and regeneration. Numerous other processes have tried and accomplished this by non-specific protein adsorption, covalent attachment, biomolecule entanglement, and synthesis …
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NKAINs: A Novel Family of Membrane Proteins that Interact with the Na, K-ATPase and Affect Membrane Excitability
… transmembrane domains, NKAINs contain no known functional domains. Striking amino acid conservation in the first two transmembrane domains suggests that the function of these proteins is concentrated in the membrane bilayer. NKAIN1, 2, 3 and a splice form of NKAIN4 are brain and testis specific; …
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Mechanism of Translational Control by the Fragile X Mental Retardation Protein and Creation of the FMRP CTAG Mouse
… Fragile X Mental Retardation Protein (FMRP) is a neuronal RNA-binding protein that is predominantly associated with polyribosomes. Loss of FMRP results in Fragile X Syndrome, characterized by mental retardation, autism and epilepsy. FMRP was recently found to be associated with a specific set of …
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The genetics of cognition in Schizophrenia
… of schizophrenia and a major determinant of functional outcomes. Cognitive function may be assessed by measuring mean performance measures on cognitive tasks or by measuring variability in performance across tasks or trials of a task that make up a cognitive test battery. Previous research …
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The genetics of cognition in Schizophrenia
… of schizophrenia and a major determinant of functional outcomes. Cognitive function may be assessed by measuring mean performance measures on cognitive tasks or by measuring variability in performance across tasks or trials of a task that make up a cognitive test battery. Previous research …
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