Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 65 for “"neuronal excitability"”.
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Regulation of Neuronal Excitability by Glutamate and Cholecystokinin Rodent Neocortex
The excitability of neuronal networks may also be modulated by neuropeptides. Cholecystokinin (CCK) is one of many neuropeptides localized in the central nervous system with relatively high concentrations in the cerebral cortex. Layer VI neocortical neurons provide important corticothalamic …
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The regulation of neuronal excitability by epilepsy-associated gene Nedd4-2
… disorders suffer from an imbalance in neuronal and circuit excitability and present with seizure or epilepsy as the common comorbidity. The onset of epilepsy can be a result of an acquired brain injury (such as a trauma) or a genetic mutation in some genes. It is widely accepted that …
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Regulation Of Neuronal Excitability: New Mechanisms For Slow Afterhyperpolarization Activation And Modulation
… that plays a critical role in the regulation of neuronal excitability. This current is modulated by receptors acting via GΑ<sub>q/11</sub> G proteins, thus it is thought that neurotransmitters regulate neuronal excitability through the inhibition of this current. I<sub>sAHP</sub> is known to be …
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Intrinsic Properties and Neuromodulator Regulation of Neuronal Excitability of Intralaminar Thalamic Neurons
… that the parafascicular nucleus consists of two neuronal subtypes that have distinct cytoarchitecture and intrinsic properties; the latter could influence their role in arousal and motor activity. I next examined the actions of cholinergic agonists on rat parafascicular nucleus neurons. The …
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Fatty acid ethanolamides pinpoint nicotinic receptors and modulate neuronal excitability through nuclear receptor PPARα
SPECIFIC AIMS OF THE STUDY 1) To investigate whether FAEs can suppress nicotine-induced stimulation of VTA dopamine (DA) neuron firing rate through the peroxisome-proliferator-activated receptor-α (PPARα) and to elucidate their mechanism of action in an in vitro brain slice preparation. 2) To …
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Circadian rhythms of redox state and regulation of neuronal excitability in suprachiasmatic nucleus of rodents
… and how such metabolic oscillations might affect neuronal physiology are unknown. Here we show a self-sustained circadian rhythm of SCN redox state that requires the molecular clockwork. The redox oscillation determines the excitability of SCN neurons through a non-transcriptional mechanism: …
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The Role of Cdk5 in the Regulation of Dopamine Neurotransmission, Neuronal Excitability, and Reward-Related Behavior
… Behavioral changes were accompanied by increased excitability of medium spiny neurons in the nucleus accumbens (NAc) in conditional Cdk5 knock-out mice. Targeted deletion of Cdk5 in the NAc facilitated cocaine-induced locomotor sensitization and conditioned place preference for cocaine. These …
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Neurobiological Substrates of Age-Associated Decline in Neuronal Excitability - Lipid Peroxidation-Dependent Modulation of Transient Potassium Current Inactivation?
… properties of the nervous system, including neuronal excitability: excitability of the nervous system declines with age and this may contribute to age-associated cognitive dysfunction. This thesis will investigate age-associated intrinsic neuronal excitability decline in the model system …
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Investigating cestode modulation of host neuronal excitability and cell-type-specific gene expression in an in vitro mouse model of neurocysticercosis
… potential links between inflammation and network excitability at a transcriptomic and electrophysiological level. In the first part of the thesis, I found that while LPS significantly affected cell-type specific gene expression associated with inflammatory pathways, it had little impact on genes …
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Regulation of in vivo excitatory/inhibitory balance by the cystine/glutamate exchanger system xc-
… to affect synaptic strength and intrinsic neuronal excitability, the main focus of this dissertation was to elucidate whether Sxc- signaling contributes to brain excitatory/inhibitory (E/I) balance in vivo. Using chemoconvulsants to uncover excitability changes in SLC7A11sut/sut mice — mice …
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The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation
… crucial for establishing proper neural circuit excitability throughout development stages, and serves an essential role in maintaining excitatory/inhibitory (E/I) balance in the central nervous system. In this thesis, I discovered potential signaling pathways that contribute to neuronal …
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Reactive oxygen species involvement in gabaergic dysfunction in neuropathic pain
… by peripheral nerve damage results in ectopic neuronal excitability, primary sensory neuron degeneration, loss of inhibition by spinal GABAergic neurons and more importantly, the development of central sensitization—increased sensitivity of dorsal horn neurons to stimuli. Oxidative stress due …
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Metabotropic Glutamate Receptor 5 in the Medial Prefrontal Cortex: Role in Cocaine Sensitization and Addiction
… is associated with cocaine-induced hyperexcitability of pyramidal projection neurons within the medial prefrontal cortex (mPFC). Such hyperexcitability presumably results in increased glutamatergic input to reward-affiliated brain regions such as the ventral tegemental area (VTA) and …
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Elucidation of the Role of miR-184 in the Development and Maintenance of the Drosophila Melanogaster Nervous System
… a voltage-gated sodium channel, shown to control neuronal excitability; and (ii) tramtrack69 (ttk69), a transcription factor known to regulate glial cell number and fate determination during embryonic development. In the absence of miR-184, homozygous loss-of-function mutant adult flies …
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Targeting protein: protein interaction sites for drug development against voltage-gated sodium channels
… potentials, which contribute to control of neuronal excitability. Malfunction of specific Nav channel isoforms is associated with a wide range of brain disorders including psychological, neurological and developmental disorders. Unfortunately, currently available drugs targeting Nav channels …
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Imaging Chloride Homeostasis in Neurons
… chloride and pH are fundamental regulators of neuronal excitability and they are often co-modulated during excitation-inhibition activity. The study of their homeostasis requires simultaneous measurements in vivo in multiple neurons. Combining random mutagenesis screening, protein engineering …
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Regulation of the FGF14:Nav Interactome by a GSK-3 Centered Pathway
… inhibitory inputs leading to dysregulations in neuronal excitability. Recent research focused on uncovering novel causes of psychiatric disorders have highlighted the importance of the axonal initial segment (AIS), a highly specialized neuronal structure critical for spike initiation of the …
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The effect of omega-3 fatty acid supplementation and transcranial direct current stimulation on plasma cytokines
… brain development and function. tDCS modulates neuronal excitability by altering the resting membrane potential of a stimulated neuron, leading to a brain benefit. We hypothesized that intake of n-3 PUFA and tDCS sessions, alone or in concert, may balance the pro- and anti-inflammatory cytokines …
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Decreased transmitter release conferred by a mutation in the slowpoke-encoded calcium-dependent potassium channel gene at the Drosophila neuromuscular junction
… in transmitter release may be due to reduced neuronal excitability conferred by the slo mutation.
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The investigation of pathophysiological mechanisms underlying KV7-related epilepsy and neurodevelopmental delay
… neurological disorder (Epilepsy Foundation). Neuronal Kv7 channels composed of Kv7.2/KCNQ2 and Kv7.3/KCNQ3 subunits are enriched at the axonal plasma membrane where their voltage-dependent potassium currents suppress neuronal excitability. Close to 400 variants in Kv7.2 subunit cause Benign …
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