Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 31 for “"neuronal circuit"”.
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A Neuronal Circuit Motif for Leaky Vector Integration
… but the fly's connectome reveals multiple vΔ-hΔ circuits, spanning different layers of the fan-shaped body. By varying leak rates and ramp rates across different vΔ-hΔ circuits, the fly brain could build a repertoire of path-integrated signals with spatiotemporal dynamics suitable for a range of …
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Control of Neuronal Circuit Assembly by Gtpase Regulators
… which is crucial for the functioning of neuronal circuits. Thus, understanding the cellular and molecular mechanisms leading to the precise assembly of neuronal circuits is a major focus of developmental neurobiology. The structural organization and specific connectivity of neuronal …
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A Neuronal Circuit Architecture for Angular Integration in Drosophila
… of their angular heading over time. However, a neuronal-circuit architecture for computing heading remains unknown in any species. In this thesis, I describe a set of neurons in the Drosophila central complex whose wiring and physiology provide a means to shift an angular heading estimate when …
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Regulation of mammalian neuronal circuit development by CPG 15
The orderly assembly of neuronal circuits is specified by developmental programs of gene expression, however, the final stage in circuit development, maturation and refinement of specific synaptic connections, is strongly influenced by neuronal activity. It is thus not surprising that the products …
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Neural substrates of avoidance behavior: The afferent limb
… by locomoting in the running wheel. Using a neuronal circuit model of discriminative active avoidance conditioning, sources of afferent input to critical learning-related limbic structures were examined for their influence on neuronal activity and behavior.
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Engineering novel neuronal circuits using HI-PSCS derived neurons and microglia
… during the development and refinement of the neuronal circuits in the brain. From previous in vivo studies, we know that microglia mediate the synaptic pruning during neuronal circuit formation, and thus we hypothesized that microglia will remodel the connections within the human cortical …
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A SINGLE GUSTATORY RECEPTOR CAN SWITCH THE INCENTIVE SALIENCE OF A SPECIFIC REWARD
… has been done on understanding the nature and circuit mechanisms of reward, how reward perception evolves to drive species-specific long-term behavioral changes remains unknown. Previously, we found that Drosophila melanogaster innate responses to a reward can be distinct from how robustly the …
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Building an Allocentric Traveling-Direction Signal Via Vector Computation
… when walking sideways). We then characterize a neuronal circuit that rotates, scales, and adds four vectors related to the fly's egocentric traveling direction––the traveling angle referenced to the body––to compute the allocentric traveling direction. This circuit operates by mapping spatial …
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The Dissociation of Sensory Integration and Associative Learning in Caenorhabditis elegans and the Molecular Mechanisms Leading to Memory Acquisition
… facilitating the overall understanding of the neuronal circuit involved in associative learning in C. elegans.
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Endogenous RNAi pathways are required in neurons for dauer formation in Caenorhabditis elegans
… decision, suggesting a role for the distributed neuronal circuit in regulating this decision. Our results also suggest that endo-RNAi governs dauer recovery decisions in pheromone induced dauers when conditions are favorable. Together, our data suggest a model wherein the CSR-1 pathway promotes …
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Neuro-Electronic Interface: Interrogating Neuronal Function and Circuitry with Innovative Approaches
… brain cells called neurons. Loss of various neuronal circuit functions, due either to stroke, epilepsy, trauma, Parkinson's, Alzheimer's or neurodegenerative diseases, renders the nervous system dysfunctional. Epilepsy alone is one of the most common and debilitating neurological disorder, …
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Converting an Allocentric Goal Direction into an Egocentric Steering Signal in Drosophila
<p>Neuronal signals relevant for spatial navigation have been described in many species, however, a circuit-level understanding of how such signals interact to guide behaviour is lacking. In this thesis, I characterize a neuronal circuit in the Drosophila central complex that compares internally …
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Immunocytochemistry, Mass Spectrometry and Microengineering for the Study of Cell Signaling
… localization and action within a particular neuronal circuit. The study tests the hypothesis that specific neuropeptide transmitters expressed in a relatively restricted number of neurons in the central nervous system might indicate on functionally-related circuit of neurons. Alternatively, …
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Mechanisms of Volatile Odorant Detection and Corresponding Behavioral Effects in Drosophila
… approach to study the role of cVA-induced neuronal activation, and found that activation of the at1 neuronal circuit involved in cVA detection, using a dominant-active form of the odorant binding protein LUSH, is both necessary and sufficient to induce sexually dimorphic mating behavior in …
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Modification of Aplysia Feeding Network By L-Dopa and Dopamine-Dependent Learning
… (DA) is a ubiquitous neuromodulator of neuronal networks in the animal kingdom and has a well-established role in modulating motor behavior and encoding reward information. Although the effects of DA and DA-dependent learning at the behavioral and molecular levels are well-understood, …
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Differential Regulation of Synaptic Plasticity In Epilepsy
… represents a basic alteration in the epileptic circuit as to how synaptic plasticity is regulated. Since effects of NRG/ErbB4 activation are via the DAergic system, we used specific DAR agonists and antagonists to examine further this shift in NRG function. We observed differential activation of …
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On the role of SOCS proteins in leptin signalling
… and downstream effects of leptin in the neuronal circuit. In addition, leptin is involved in a broad range of other, often peripheral, physiological functions including reproduction, bone formation and immunity, and may also contribute to the development of disorders like auto-immune …
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The Role of CNTNAP2 in the Development & Evolution of the Human Cerebral Cortex
… primates are accompanied by changes to forebrain neuronal circuit composition and function. This is underpinned by species-specific features of their development. Excitatory neurons in the human cerebral cortex have longer neurites and more elaborate neurite branching than chimpanzees or macaques, …
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