Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 49 for “"neuronal cell death"”.
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Monoamine oxidase in neuronal cell death
… (ROS) contribute to oxidative stress in the cell and can directly inhibit electron transport, cause damage to mitochondrial DNA and enhance cell death signalling. In this study the role of MAO in cell death was investigated in dopaminergic neuroblastoma (SH-SY5Y) cells, in three diverse …
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Involvement of the Sigma-1 Receptor in Neuronal Cell Death and Alzheimer's Disease
… are thought to be correlated with progressive neuronal cell death in AD. Aβ leads to increased endoplasmic reticulum (ER) stress, decreased autophagy, and increased apoptosis, all of which may be contributing to the neuronal cell death that is seen in AD. The Sig-1R is known to reduce ER …
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Strategies for Neuroprotection Using Passive (Neurotrophin-Deprivation) and Active (Virotoxin Exposure) Models of Neuronal Cell Death
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2004.
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Deciphering the mechanism by which humanin binding to IGFBP3 inhibits neuronal cell death in alzheimer’s disease
… humanin (HN) counteracts this IGFBP3-induced cell death. Unfortunately, the natural synthesis of this peptide decreases with age coincident with the time that people are likely to develop AD. In addition, the precise mechanism of action of HN is currently unknown. We have synthesized residues …
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Mitochondrial permeability transition following calcium overload. - Its role in neuronal cell death and potential as a pharmacological target.
… neuroprotective properties to limit the evolving cell death following e.g. stroke or traumatic brain injury. The mitochondrial permeability transition (mPT) is a potential pathological mechanism causing cell death in the CNS. As the name implies, the mPT is defined by a sudden increase in …
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Development of P7C3-Class of Neuroprotective Molecules
… these neuropsychiatric conditions have in common neuronal cell death, for which there is currently no effective pharmacologic treatment. Here, I describe the development of the P7C3-series of neuroprotective compounds, which were originally discovered through an unbiased in-vivo screen for new …
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Glutamate Excitotoxicty Activates a Novel Calcium Permeable Ion Channel in Cultured Hippocampal Neurons
… is the predominant mechanism implicated in neuronal cell death associated with neurological disorders such as stroke, epilepsy, traumatic brain injury and ALS. Excessive stimulation of NMDA subtypes of glutamate receptors leads to protracted intracellular calcium elevations triggering …
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A tailored biocompatible neural interface for long term monitoring in neural networks
… affect the development of a glial scar and neuronal cell death surrounding probes. After many cycles of testing – refinements, promising recordings of neural activity were obtained in both cerebellum and cortex cerebri (papers I-III). In paper IV, we evaluated the importance of mechanical …
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Pesticides and Pesticide Mixtures Induce Neurotoxicity: Potentiation of Apoptosis and Oxidative Stress
… to investigate the mechanism(s) of induction of neuronal cell death caused by these pesticides using human neuroblastoma SH-SY5Y cells in culture, (4) to define the role of oxidative stress in pesticide-induced neuronal cell death in vitro. Male C57Bl/6 mice of 7-9 months old exposed to zineb (50 …
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Systemic AAV-Mediated Gene Therapy Using Epo-R76E to Protect Retinal Ganglion Cells from Optic Nerve Injury and Disease
… is a strategy to prevent or reduce neuronal cell death regardless of the underlying cause. Erythropoietin (EPO) exhibits neuroprotective effects in a variety of <em>in vitro</em> and <em>in vivo </em>models of neuronal cell death although its classical function is the regulation of …
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Beneficial Effect of the Flavonoid Luteolin on Neuroinflammation
… agent for preventing neuroinflammation and neuronal cell death mediated by activated microglia and consequently, attenuating age-associated cognitive decline.
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Misregulation of Iron Handling Proteins in Excitotoxic Brain Injury
… reactive oxygen species (ROS), which can cause neuronal death in neurodegenerative diseases. The present study was also carried out to elucidate the expression of iron handling proteins such as divalent metal transporter-1 (DMT1) isoforms, iron regulatory proteins (IRPs), and ferritin in the …
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The role of cytosolic phospholipase A2 in microglial signaling pathways during neuroinflammation
… injury. Microglia are the primary innate immune cells in the central nervous system (CNS). These cells are the first line of defense against foreign pathogens, and the exhibit multiple physiological roles including removing cellular debris and maintaining tissue homeostasis. Pathologic activation …
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Neuroprotection of AG490 in Oxidative Stress-induced Neuronal Death
… free radicals, which has an important role in neuronal death. Free radicals oxidize intracellular molecules, the destabilization of membrane integrity, and the mitochondrial dysfunction. In present study, we investigated whether AG490, a specific Janus kinases 2 (JAK2) inhibitor had an effect …
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Genomic and non genomic effects of elevated concentration of anabolic steroids in human neuronal cells
… of neurotransmitter systems and contribute to neuronal cell death. This effect can explain the behavioural changes, drug dependence and neuro degeneration observed in steroid abuser. Nandrolone treatment (10-8M–10-5M) caused a time- and concentration-dependent downregulation of mu opioid …
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Neural Development to Neurodegeneration Through the Mind of a Worm
… of an organism. By examining mutations during neuronal development, we can better understand the significance of specific pathways. The EphR/ephrin pathway is crucial for axonal guidance during development. The simple organism, <em>C. elegans</em>, allow us to study the impact of EphR/ephrin …
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Of mice and men: can MMP-9 be a biomarker and a potential target for treatment after traumatic brain injury?
… injury (TBI) is a highly prevalent cause of death and disability in the US and has become a significant burden to our present healthcare system. Currently there are few biomarkers and clinical diagnostic tests to determine the severity of TBI in humans. In addition, there are few efficacious …
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E2F6 in axial skeletal development and gliosis
… were originally identified as regulators of cell cycle and cellular proliferation. In vivo mouse models have uncovered novel roles for these proteins in different developmental processes. This dissertation examines the biological role of E2F6 in mammalian development. E2F6 functions as a …
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Alzheimer's Disease and Amyloid Beta: Effects of amyloid beta on hippocampal and dorsal root ganglion neurons' electrophyiology and morphology
… hamper neurons’ communication, cause progressive neuronal cell death in the central nervous system, and ultimately lead to memory loss in the individual. While disease symptoms are well known, the mechanism by which Aβ triggers the degeneration of the brain remains elusive. There is no cure for AD …
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