Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 222 for “"neuronal activity"”.
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Transcriptional Mechanisms Underlying Neuronal Activity-Dependent Plasticity
Pages 1-110 are misnumbered as pages 2-111.
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Neuronal activity and membrane turnover in rat brain
Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Brain and Cognitive Sciences, 1993.
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Developing tools to investigate neuronal activity in synaptic pruning /
… and contributes to the formation of mature neuronal network. Synaptic pruning is performed by microglia that phagocytose synaptic material. It is essential to achieve optimal neural network and healthy nervous system. The impairments of synaptic pruning were linked to a variety of …
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Mechanisms of Specificity in Neuronal Activity-regulated Gene Transcription
… sensory stimuli into temporal patterns of neuronal activity, which in turn modulate the connectivity and strength of neural circuits in the brain. These long-term plastic changes in the brain are known to depend on the neuronal activity-regulated transcription of new gene products. My …
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The Role of Neuronal Activity in Adult Myelin Plasticity
… learning. Research has also demonstrated that neuronal activity plays a central role in early myelin development and promotes oligodendrogenesis and adaptive myelination. Thus, it becomes important to understand how neuronal activity affects myelin. In this thesis, the role of neuronal activity …
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Models for the study of neuronal activity during cognitive tasks
Assessment of brain connectivity among different brain areas during cognitive or motor tasks is a crucial problem in neuroscience today. Aim of this research study is to use neural mass models to assess the effect of various connectivity patterns in cortical EEG power spectral density (PSD), and …
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Behavioral Responses to Methylphenidate: Correlations With Neuronal Activity In The Caudate Nucleus
… differences in the CN electrophysiological activity of animals exhibiting different chronic responses to the same dose of MPH. Behavioral and caudate nucleus (CN) neuronal activity following acute and chronic doses of MPH was assessed by simultaneously recording the behavioral and neuronal …
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On the functional role of oscillatory neuronal activity in the somatosensory system
Contains fulltext : 92578.pdf (Publisher’s version ) (Open Access)
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A multi-photon microscope for three dimensional functional recording of fast neuronal activity
… limitations complicate any attempt to study neuronal function with sub-cellular resolution: First, neurons and neuronal processes are small, second, in realistic experimental situations they can be located deep within optically scattering tissue, third, the chemical and electrical signaling …
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Mechanism of transcranial focused ultrasound regulating the neuronal activity of the retrosplenial cortex
… tFUS has become a novel method for regulating neuronal activity by means of its non-invasion, reversibility, and accuracy. However, how tFUS regulates neuronal activity and cellular properties in response to tFUS remains unknown. To investigate how tFUS regulates neuronal activity, I used …
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Modulation of RNA Cytosine-5 Methylation by Neuronal Activity and Methyl-donor Folate
… described in chapter 2, we adopt a widely used neuronal activity model, and perform RNA sequencing (RNA-seq) and RNA bisulfite sequencing (RNA BS-seq) to profile gene expression as well as transcriptome-wide 5-mrC modification. We have identified distinct gene expression profiles and …
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Intracellular delivery and voltage sensitivity of nanomaterials for the optical imaging of neuronal activity
… extracellular space and implemented to image the activity of neuronal assemblies. The first part of this thesis explores the implementation of VSM in another scenario, i.e., the voltage imaging from multiple sites on single neurons. After direct intracellular delivery, amphiphilic nanomaterials …
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Transitioning Between Preparatory and Precisely Sequenced Neuronal Activity in Production of a Skilled Motor Behavior
… learned song and exhibit precise sequential activity during singing. Using cell-type specific calcium imaging we identify populations of HVC premotor neurons associated with the beginning and ending of singing-related neural sequences. We characterize neurons that bookend singing-related …
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The study of Murine double minute-2 (Mdm2) in regulating neuronal activity-dependent protein translation
… potential signaling pathways that contribute to neuronal excitability regulation upon various external stimuli. In Chapter II, I focused on determining the underlying molecular pathways that elevate neuronal excitability upon activating Group 1 metabotropic glutamate receptors (Gp1 mGluRs). While …
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State-dependent changes in astrocyte regulation of extrasynaptic NMDA receptor signaling in neurosecretory neurons
… space, such as the topography of the neuronal–glial microenvironment, as well as glial glutamate transporters, are expected to affect eNMDAR-mediated signalling strength. In this study, we used <i>in vitro</i> and <i>in vivo</i> electrophysiological recordings to assess the properties, …
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Transcranial alternating current stimulation to areas associated with the human mirror neuron system reveals modulation to mu-suppression and corresponding behaviour
… of human mirror neuron system (hMNS) related activity. The hMNS is characterized by neuronal activity that responds to both action observation and execution of the same movement. This activity has been directly observed in both macaque monkeys and in humans. There is an abundance of studies …
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The Neurobiology of Social Cognition: Role of the Posterior Cingulate Cortex
… in social cognition. Human studies show that PCC activity varies with the recall of autobiographical memories and exposure to social stimuli. While several electrophysiological studies explicate the response of PCC neurons to non-social outcome monitoring and valuation, there is a lack of similar …
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Mechanisms of Brain Region-Specific Amyloid-beta Deposition
… with the concentration of lactate, a marker of neuronal activity. Moreover, we found that physiological modulation of endogenous neuronal activity by vibrissal manipulation was sufficient to modulate ISF Aβ levels and amyloid plaque growth dynamics. Using a novel optical intrinsic signal …
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Effect of hypoxia on spontaneous neural activity in the cortex of neonate mouse pups
… of acute hypoxia occurring perinatally, on neuronal activity remain less studied. Spontaneous neural activity occurring during the first weeks of development is important for priming the nervous system to function efficiently when encountering sensory-evoked inputs. This calls for the need …
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Effect of hypoxia on spontaneous neural activity in the cortex of neonate mouse pups
… of acute hypoxia occurring perinatally, on neuronal activity remain less studied. Spontaneous neural activity occurring during the first weeks of development is important for priming the nervous system to function efficiently when encountering sensory-evoked inputs. This calls for the need …
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