Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"neuron loss"”.
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Selective damage to and protection of enteric neurons in vitro in models of ischemia and reperfusion
… intestinal inflammation is typified by the early loss of enteric neurons. It has been proposed that ischemia may occur in intestinal inflammation, due to the organization of splanchnic circulation combined with local inflammatory damage. Therefore, we hypothesized that the ENS experiences ischemic …
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Old-age hippocampal sclerosis in the aged population
… sclerosis (HS), characterised by severe neuron loss in hippocampal CA1, is a poorly understood cause of dementia. At present no objective pathological HS criteria exist. In life HS is commonly diagnosed as Alzheimer's disease. HS aetiology is unclear, although it has been associated with …
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Tumor Necrosis Factor Dependent Mechanisms and Neuroprotective Strategies in Models of Parkinson's Disease
… neurodegenerative disorder characterized by the loss of dopaminergic neurons in the substantia nigra that innervate the striatum. Although the nigral cell loss that causes motor dysfunction in Parkinson's disease has been identified for some time, the mechanisms that lead to this dopaminergic …
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ANATOMICAL AND ELECTROPHYSIOLOGICAL STUDIES OF AN ANIMAL MODEL OF TEMPORAL LOBE EPILEPSY WITH CLASSIC HIPPOCAMPAL SCLEROSIS
… a characteristic pattern of hippocampal neuron loss called "classic hippocampal sclerosis." No single injury has reproduced this extensive neuron loss experimentally, suggesting that hippocampal sclerosis may be an "endstage" pathology caused by an initial insult plus years of spontaneous …
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TARGETING REDOX IN AGING AND ALZHEIMER'S DISEASE
… can be reversed using redox interventions in neurons and C) modification of the extracellular Cys/CySS redox can change intracellular redox and increase neuron survival. Hippocampal/cortical neurons were isolated across the age-span from non-transgenic (non-Tg) and a triple transgenic …
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The role of the de novo DNA methyltransferase Dnmt3a in the nervous system
… defect. Dnmt3a mutants also exhibited motor neuron loss and fragmented neuromuscular junction synapses. These results support a requirement for DNA methyltransferase activity in the neuromuscular system.
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Age-Dependent Effects Of Chronic GABAA Receptor Blockade In Barrel Cortex
… during the second postnatal week, at a time when neurons in the developing rat cortex are vulnerable to excitotoxic effects. To test whether these GABAA receptors might serve to protect neurons from excessive excitatory input, polymer implants containing the GABAA receptor antagonist bicuculline …
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Neurological Consequences of Viral Encephalitis: Behavioral Deficits, Neuronal Restructuring, and Therapeutic Interventions
… neurodegenerative disorders linked with aging. Neuronal degeneration, a hallmark of neurodegenerative diseases and viral neuropathologies, involves the progressive loss of neuronal structure and function, often leading to memory dysfunction, motor impairments, and chronic inflammation. We study …
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Influence of Sex, Adolescence, and Aging on the Rat Basolateral Amygdala
… in spine density across age. In study two, neuron number was quantified with stereological methods in the male and female basolateral amygdala at four different ages across the lifespan. The period between adolescence and adulthood was found to be accompanied by significant neuron loss in …
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Predicting Vision Loss In Healthy Aging With Manganese-Enhanced Mri Of The Rat Eye
… throughout adulthood. Age-related changes in neuronal ion homeostasis -- specifically, increased Ca2+ influx through L-type voltage gated calcium channels (L-VGCCs) -- are believed to contribute to certain functional declines, but this possibility has not yet been tested in the neural retina. …
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Pathogenic impact of immune-related cells in Batten disease
The neuronal ceroid lipofuscinoses (NCLs or Batten disease) are inherited neurodegenerative diseases of children. In all types of NCL glial activation, the innate immune response of the brain, precedes neurodegeneration. However, it is unclear whether adaptive immune responses are also involved in …
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THE EFFECTS OF NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE 2 (NMNAT2) ON MOUSE NERVE AND BLADDER DEVELOPMENT
… is now data that supports the compartmentalized neuron loss theory where each compartment of a nerve cell has a distinct mechanism of maintenance and death. In axons, the Wlds protein is the most widely studied for its ability to delay Wallerian degeneration. Studies have linked the Nmnat1 …
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Surprising Behavioral and Neurochemical Enhancements in Mice with Combined Mutations Linked to Parkinson's Disease
… causes progressive death of dopamine-producing neurons in the substrantia nigra and depleted dopamine in the striatum. Loss of striatal dopamine results in locomotor symptoms such as bradykinesia, tremor, rigidity and postural instability. Although most forms of the disease are spontaneous, a …
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Applications for human neural stem cell-derived motor neurons in amyotrophic lateral sclerosis: Cell replacement therapy and disease modeling
… selective degeneration of spinal and upper motor neurons. One approach in the development of therapies for ALS is to explore the potential of human fetal neural stem cells (hNSCs) to replace lost motor neurons. The therapeutic efficacy of stem cell transplantation would depend greatly on the …
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The Role of Tumor Necrosis Factor (TNF) in Microglial Activation and Progressive Degeneration of Dopaminergic Neurons
… neurodegenerative disorder characterized by a loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). A number of studies have implicated chronic inflammation in the pathophysiology of PD; however, it is unclear which inflammatory mechanisms directly contribute to …
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Striatal Dopamine Release by Serotonergic Terminals in the Dopamine-Depleted Rat
… disease (PD) results from severe dopamine (DA) neuron loss within the substantia nigra pars compacta. In an effort to replace the diminished DA levels, L-dopa, the precursor of DA, is administered. Although the most commonly prescribed medication, the site(s) where L-dopa is converted to DA is …
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Translational defects in multiple tissues from the Smn2B/- mouse model of SMA.
… deletions and mutations in the survival of motor neuron (SMN1) gene and is marked by motor neuron loss and muscle weakness. While its genetic basis is clear, the underlying molecular mechanisms remain elusive. Decreased levels of the survival of motor neuron (SMN) protein, encoded by the SMN1 …
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Analysis of Therapeutic Effect after Human Mesenchymal Stem Cell Transplantation in Ischemic Stroke Rat
… staining showed that most of the endogenous neuronal progenitor cells, but few human MSCs, expressed neuronal and glial phenotypes. Tissue levels of trophic factors, including glial cell-line-derived neurotrophic factor, nerve growth factor, vascular endothelial growth factor, and hepatocyte …
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Analysing the biological function of PS2V: an aberrant splicing phenomenon or evolutionarily conserved mechanism in Alzheimer’s disease
… disorder with pathologies such as neuron loss, glial cell proliferation, extracellular deposition of senile plaques from the accumulation of amyloid beta (Aβ) peptides and deposition of intracellular neurofibrillary tangles. Aβ is generated from the cleavage of the Amyloid Precursor …
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Interactions Between Microbial, Neuronal, and Immune Cells in the Digestive System
… largest immune compartment, as well as a vast neuronal network, the enteric nervous system (ENS). In concert with the commensal intestinal microbiota, the enteric immune and nervous systems communicate with one another, and this crosstalk was the focus of my thesis work. The studies as …