Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 14 of 14 for “"neuron differentiation"”.
-
The Dual Role of Notch Signaling During Motor Neuron Differentiation
… spinal cord, Olig2+ progenitors in the motor neuron progenitor domain give rise to an impressive array of motor neurons, oligodendrocytes and astrocytes. Motor neurons are further diversified into motor columns and pools based on cell body settling position, general axonal trajectories, and …
-
Function of the forkhead gene fd3F in Drosophila chordotonal neuron differentiation
… hearing. The outer dendritic segment of the Ch neuron is a compartmentalised motile cilium, a feature that is exclusive to this neuron subtype. Ch organs are specified early in development by expression of the proneural gene atonal in the proneural cluster and sense organ precursors (SOPs) …
-
Sonic hedgehog induces Motor Neuron Differentiation in P19 Embryonic Carcinoma Cells
… the fates of oligodendrocytes and motor neurons as well as proliferation of neural precursors and control of axon outgrowth. To explore the roles of Shh in neuronal differentiation, we utilized embryonal carcinomal P19 cells as an in vitro model system. We overexpressed Shh in P19 cells …
-
Non-Parametric Analyses of the Regulatory Roles of LINE-1 Retrotransposons during Motor Neuron Differentiation
Background: Repetitive elements make up a large portion of eukaryotic genomes, constituting two-thirds of human genome. Although their functional importance were recognized as early as 1950s, study of their functions is stagnated despite the advancements in next-generation sequencing due to …
-
ELUCIDATING THE ROLE OF BCAT1 IN MITOCHONDRIAL FUNCTION AND NEURODEVELOPMENT
… and immune cell function, the role of BCAT1 in neuronal development and mitochondrial function remains elusive. Further, while recent findings link alterations in BCAT1 activity to neurological disorders, few are well-studied in the context of the brain. The work described here combines both in …
-
Methods and Mechanisms of DNA Methylation in Development and Disease
… regulation and is required for normal cellular differentiation. Failure to properly establish or maintain DNA methylation patterns leads to cell dysfunction and diseases such as cancer and neurological disorders. The goal of this thesis is to understand the role of DNA methylation in oncological …
-
THE ROLE OF SKELETAL MUSCLE SYNTHESIZED BRAIN-DERIVED NEUROTROPHIC FACTOR (BDNF) ON THE HEALTH AND MAINTENANCE OF THE MURINE MOTOR UNIT
… is a small neurotrophic protein, that regulates neuron differentiation, maturation, and survival, and modulates central nervous system neurotransmitters (Oppenheim, 1991; Acheson et al., 1995; Binder and Scharfman, 2004; Reichardt, 2006). However, the role of BDNF in skeletal muscle health and …
-
Characterization and Fabrication of Scaffold Materials for Tissue Engineering
… material can largely influence cell growth and differentiation. The macro- and meso- structures of the scaffold, along with the functional groups or growth factors present on the surface plays an important role in cell function. Poly(ester urea) (PEU) is regarded as a promising biodegradable …
-
VOLTAGE GATED SODIUM CHANNEL AND NEURONAL DIFFERENTIATION. IMPLICATIONS IN AMYOTROPHIC LATERAL SCLEROSIS PATHOGENESIS
… to be fundamental in axonal outgrowth in mouse neuron primary culture. Moreover, our previous studies on a zebrafish model of Amyotrophic Lateral Sclerosis, that express the mutant G93R form of the superoxide dismutase 1 (SOD1) enzyme, show that alteration in the INaP of spinal inter- and moto- …
-
Systematic Co-Culture of IPSC-CM and IPSC-AN Promote Co-Maturation In Vitro
… function. In native heart muscle, sympathetic neurons (SN) and parasympathetic neurons (PSN) modulate the beat rate of cardiomyocytes (CM) to maintain homeostasis. Pluripotent stem cells can differentiate into CM, but differentiated CMs are fetal-like, with a high beat rate, and lack organized …
-
Regulation and function of genes involved in drosophila ciliogenesis
… each type of SOP to acquire both generic neuronal properties and individual neuronal subtype identity during the progression from specification to differentiation. To approach this question, we investigate the gene regulatory network by proneural protein Ato by means of the microarray …
-
Development of a Workflow to study Neuronal Injury In Vivo in the Retina and In Vitro in Collagen Hydrogels
… isolation, an in vitro model of compression to neuronal cells was developed in Aim 2. The first aim of the study employed an established preclinical blast model to expose the entire body of rats to three blast waves, each one hour apart. Immunohistochemistry was performed on retinas isolated …
-
Deep vertebrate roots for mammalian krab zinc-finger transcription factors
… the functional role of this ancient gene in neuron development. In chapter 3, I show that mouse Zfp777 is expressed in neuronal stem cells (NSC) cultured from early mouse embryos, with a pattern that changes over the course of neuron differentiation in vitro. Using the NSC platform, I …
-
Human Stem Cells for Modeling Amyotrophic Lateral Sclerosis Disease Mechanisms and Modifiers
… from the inaccessibility of living human motor neurons for use in disease research and subsequent therapeutic target validation. Recent developments in the field of stem cell biology can potentially provide access to living human motor neurons from individual ALS patients. It is now possible to …