Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 22 for “"neuron development"”.
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Morphological characterization of medium spiny neuron development in vitro
Medium Spiny Neurons (MSNs) are the primary cell type of the striatum, a structure critically involved in motivation, memory, and movement. MSN structure and function are altered in Parkinson’s and Huntington’s disease as well as following repeated exposure to drugs of abuse. One site on the MSN …
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Functional Analysis of SOX11 and NF1 in Sensory Neuron Development and Plasticity
Development of sensory neurons is controlled by both cell-extrinsic and cell-intrinsic factors. The transcription factor Sox11 is abundantly expressed in embryonic sensory neurons. In the first part of this thesis, by using a Sox11-/- mouse model, I show that the loss of Sox11 results in increased …
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P120-Catenin Subfamily Members Have Distinct As Well As Shared Effects On Dendrite Morphology During Neuron Development In Vitro
<p>Proper dendrite morphology is essential for neuronal connectivity and function, and abnormal dendrite morphology is seen in many neurological pathologies. This study characterizes and compares the effects of a group of four proteins – the p120-catenin subfamily – that regulate cytoskeletal …
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Mosaic Analysis of Neurogenesis and Neuronal Morphogenesis in Drosophila Learning and Memory Center Mushroom Bodies
… single-cell or subcell lineages born at specific developmental stages, was performed for identification of novel genes involved in MB neuron development. Of 1200 mutant chromosome arms of 2L screened, two interesting genes were identified and their functions in MB neuron development were further …
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The Role of Vps54 in Drosophila melanogaster Neuronal Development and Age Progressive Neurodegeneration
… is subsequently used as a model for human motor neuron disease. Presently, it is unclear how disruption of GARP complex function leads to motor neuron degeneration. To better understand the role of Vps54 in motor neuron development, function, and age-related neurodegeneration, we disrupted …
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A novel computational method for inferring dynamic genetic regulatory trajectories
… posttranslational modifications during motor neuron development. In particular, the trajectories taken by the Hox genes through the space of regulatory states are characterized. Understanding the dynamics of Hox regulation is important because the Hox genes play a fundamental role in the …
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Development of leg motor neurons in drosophila melanogaster
… walk and fly using legs and wings. Leg motor neurons control multi-jointed leg movement by coordinately regulating leg muscle contractions. With the aim of understanding how Drosophila leg motor neurons are specified, in Chapter One, I give a general introduction of the mechanisms that …
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Identifying chromatin interactions at high spatial resolution
… data from embryonic stem cells and motor neuron progenitors and make several observations about the usage of enhancers during motor neuron development.
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NOVEL INSIGHTS INTO GENETIC AND ENVIRONMENTAL DETERMINANTS SHAPING GNRH NEURON BIOLOGY AND RELATED REPRODUCTIVE DISORDERS
… and sex steroid production. GnRH-secreting neurons originate from the olfactory placode during embryogenesis and migrate into the forebrain to reach the hypothalamus, where they integrate into the reproductive axis. This migratory journey depends on tightly regulated molecular mechanisms …
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Molecular targets of chromatin marks H3K4ME3, H3K9ME3 and H3K27ME3 in an adult germinal niche
… and morphology, proliferation and survival, neuron development. Taken together these processes suggest histone modifications, predominantly H3K27me3, are responsible for maintenance of NSC identity. Our findings also highlight the importance of using in vivo models to study the SVZ neurogenic …
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Impaired N-Glycosylation Processing Impacts Neuronal Function
… rapidly than other K channels, thus allowing neurons to create trains of action potentials. Kv3.1b is N-glycosylated at two sites, the N220 site and N229. The first aim of this study was to examine caudal primary (CaP) motor neuron development and the motor activity of WT AB larval zebrafish …
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Deep vertebrate roots for mammalian krab zinc-finger transcription factors
… shown to play critical roles in placental development. Since ZNF777 is also expressed in embryonic brain, we sought to further investigate the functional role of this ancient gene in neuron development. In chapter 3, I show that mouse Zfp777 is expressed in neuronal stem cells (NSC) …
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The Role of Wnt Signaling in Development of the Ophthalmic Trigeminal Placode.
… to the vertebrate peripheral nervous system. The development of the ophthalmic trigeminal (opV) placode, which gives rise only to sensory neurons of the ophthalmic lobe of the trigeminal ganglion, is a well-studied model of sensory neuron development. While key differentiation processes have been …
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Chromatin accessibility informs cell identity: studies in silico, in vitro, and in vivo
… sequence and chromatin accessibility through the development of a novel massively parallel reporter assay for chromatin accessibility. In collaboration with Budhaditya Banerjee and Rich Sherwood, we identify DNA sequence features and subtle influences of transcription factor ordering within a …
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Machine Learning Applications For Neurological Diseases
… data. Some chapters focus primarily on the development of novel machine learning methods, while others discuss the implementation of established algorithms leading to significant advancements in our understanding of the given disease. Chapter 2 details a novel gene set scoring algorithm that …
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Nicotine Alters Gene Regulatory Networks in Dopaminergic Neurons in the Ventral Tegmental Area
… smoking during pregnancy is associated with developmental, cognitive, and behavioral disorders, including a predisposition to drug abuse later in life. Studies have shown that nicotine, the primary addictive and psychoactive component of tobacco, modulates gene expression in many brain …
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Manipulating soft materials to direct cell growth in multiple dimensions
… Thus, there has been increased interest in the development of three-dimensional fabrication techniques to create microenvironments that can better mimic those found in vivo. Direct-write assembly is an example of a three-dimensional fabrication method that enables the creation of micro-periodic …
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REGULATION OF NEURAL CREST DEVELOPMENT REQUIRES FUNCTIONAL INTERACTIONS BETWEEN HDAC1, TFAP2A AND FOXD3
… a wide variety of cell types including glia and neurons of the peripheral neurvous system, pigment cells and elements of the craniofacial skeleton. However, the mechanisms regulating the process of neural crest cell diversification (NCCD) are incompletely understood. A number of transcription …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… around the world. Stroke leads to loss of neurons and also other cells in the brain due to lack of blood supply. Currently no therapies are available to treat stroke-related disability. It has been shown that stroke leads to increased neurogenesis, birth of new neurons, within the brain. …
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The role of the dopaminergic neurotrophin growth/differentiation factor-5 in the developing rat ventral midbrain
… factor for embryonic midbrain dopaminergic neurons in vitro (Krieglstein et al. 1995) and after transplantation to adult rats in vivo (Sullivan et al. 1998). GDF-5 has also been shown to have neuroprotective and neurorestorative effects on adult dopaminergic neurons in the substantia nigra …
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