Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 23 for “"neuron activity"”.
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In-vivo analysis of hypothalamic kisspeptin neuron activity patterns
… by two populations of hypothalamic kisspeptin neurons located in the arcuate nucleus (ARNKISS), known as the pulse generator, and in the rostral periventricular area of the third ventricle (RP3VKISS) operating as the surge generator. The pituitary gland responds to GnRH by releasing luteinizing …
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Hormone Regulation of NPY Neuron Activity in the Arcuate Nucleus of the Hypothalamus
Neuropeptide Y (NPY)-expressing neurons in the arcuate nucleus of the hypothalamus are part of a neuroendocrine feedback loop that regulates feeding behavior and glucose homeostasis. NPY neurons sense peripheral signals of energy stores, including the hormones leptin, insulin, and ghrelin, and …
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Through a Mirror Darkly: Shedding Light on Individual Differences in the Neural Correlates of Empathy
… studies to gain a better understanding of mirror neuron activity as a putative index of empathy and its relationship with self-report measures of empathy. In the first study we built upon the existing literature by exposing participants to two EEG protocols. Findings demonstrated a more reactive …
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Functional Identification of Nucleus Tractus Solitarius (NTS) Barosensitive Neurons: Effect of Chronic Intermittent Hypoxia (CIH)
… technique, we recorded NTS barosensitive neurons in response to arterial pressure (AP) changes induced by descending aorta occlusion. Our data indicated that 1) the mean arterial pressure and HR were similar in RA control and CIH groups. 2) The majority of neurons from RA and CIH NTS …
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Hypothalamic control of energy rheostasis during metabolic challenges, pregnancy, and lactation
… revealed that pregnancy increases AgRP neuron activity and decreases POMC neuron activity in the arcuate nucleus. Chemogenetic activation of POMC neurons or inhibition of AgRP neurons suppressed pregnancy-induced feeding, indicating that these changes are required for gestational …
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Comparative single-cell transcriptomics of complete insect nervous systems
… innate and learnt behaviour. Gene expression, neuron activity, and neuron connectivity influence information processing, but bridging the gap between genes, circuits and behaviour has been very difficult. Furthermore, behavioural state of an animal continuously changes. State changes occur …
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Disrupted female reproductive cyclicity and gonadotropin-releasing hormone neuron dysfunction in a mouse model of temporal lobe epilepsy
… gonadotropin-releasing hormone (GnRH) neurons are key players in the neural control of reproduction through the hypothalamic-pituitary-gonadal (HPG) axis. At two months post-injection, the effects of epilepsy on the GnRH neuron function are dynamic across the estrous cycle, associated …
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Novel hypothalamic G protein-coupled receptors involved in the control of reproduction
… hormone (GnRH). Defects in GnRH neuron activity are associated with reproductive dysfunctions including normosmic congenital hypogonadotropic hypogonadism (nCHH) and Kallmann syndrome (KS). DNA from a cohort of European nCHH/KS patients was exome sequenced. Mutations in GPCR genes …
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Investigating neuronal mitochondrial DNA loss in Drosophila melanogaster
… the pathological consequences of mtDNA loss in neurons are very poorly understood.<br/><br/>We have used the fruitfly, Drosophila melanogaster, to study how loss of mtDNA affects neuronal function. We find that both ubiquitous RNAi and overexpression of the mtDNA binding protein TFAM causes …
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Neuromodulation Based Control of Autonomous Robots on a Cloud Computing Platform
… The neural network incorporates three types of neurons- cholinergic and noradrenergic (ACh/NE) neurons for attention focusing and action selection, dopaminergic (DA) neurons for rewards- and curiosity-seeking, and serotonergic (5-HT) neurons for risk aversion behaviors. This model depicts neuron …
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Technology Development for the Functional and Structural Analysis of the Brain
… the brain is supported by glia, which modulates neuron activity, and potassium’s dysregulation has been observed in several neurological diseases. I present the design and characterization of a family of genetically encoded potassium indicators using a potassium binding protein (Kbp) and the …
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Prefrontal coding of naturalistic working memory: Mechanisms during normal maintenance and modelled disease
Neural activity in the primate lateral prefrontal cortex (LPFC) has been causally linked to working memory (WM) — the brief maintenance and mental manipulation of information. Primates use WM to perform tasks in complex contexts; however, neural mechanisms of WM and the pathophysiology related to …
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Hormonal mechanisms for variation in female mate choice
… induction, specifically egr-1, was used to mark neuron activity. Females were treated with either HCG or saline and exposed to either mate choruses or silence. Egr-1 expression was quantified in an auditory midbrain nucleus, the torus semicircularis (TS). The region within the TS responsible for …
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High bandwidth neural interfacing using visible light communication
… restrictions with respect to the number of neurons that can be observed simultaneously. Many techniques focus on smaller nerve cell populations, and introduce wired electrode interfaces directly contacting neural tissue. These tethered methods however can lead to a host of detrimental …
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One tick closer to a better understanding of tick physiology and how to incorporate tick biology in a classroom
… 3, I conducted a study aimed to identify the neurons associated with the black-legged tick’s Haller’s organ and what odors I. scapularis can detect using their Haller’s organ. Neuron identification was accomplished by puncturing sensilla within the Haller’s organ of female black-legged ticks …
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Biophysical Model of Retraction Motor Neurons and Their Modification by Operant Conditioning
… that contains a relatively small number of neurons. This CPG generates rhythmic motor patterns (BMPs) that move food into the gut by closing a tongue-like structure (i.e., radula) during the retraction phase of the BMP (Susswein and Byrne, 1988). Recent studies show that OC leads to …
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Neuronal cicuits and reinforcement mechanisms underlying feeding behaviour
… establishing the specific roles of homeostatic neurons, which sense the body’s energetic state and elicit complex and flexible food seeking behaviours. Recent developments in optogenetics, molecular genetics, and anatomical techniques have made these investigations possible at the resolution of …
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Mas Receptor Agonism for the Treatment of Amyotrophic Lateral Sclerosis (ALS)
… disease characterized by the loss of motor neurons, leading to complete paralysis and death. As of today, approximately 32,000 people are suffering from ALS within the United States, with a worldwide prevalence reaching about 250,000 people. This number is expected to increase by 69% by …
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The Role of Parvalbumin Interneurons in Mouse Primary Visual Cortex during Visual Discrimination and Perceptual Learning
… are the most common class of inhibitory interneurons in the rodent cortex and play important roles in balancing cortical circuit activity and learning (Xu et al., 2010). PV cells are suggested to mediate feedforward inhibition and control gain modulation (Markram et al., 2004; Tremblay et al., …
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