Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 29 for “"neuromuscular disease"”.
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A role for RNA localization in the human neuromuscular disease myotonic dystrophy
… that RNA (mis)localization underlies the human disease myotonic dystrophy (DM). DM, the most prevalent adult muscular dystrophy, is caused independently by two alleles: DM1 is characterized by a (CTG)n expansion in the DM kinase (DMPK) gene 3' untranslated region while DM2 has a mutation in a …
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The effect of inspiratory muscle training on clinical outcomes and health-related quality of life in children with neuromuscular disease and respiratory muscle weakness.
… morbidity and mortality in children with neuromuscular disease. Inspiratory muscle training aims to preserve or improve respiratory muscle strength, reduce respiratory complications and improve health-related quality of life. Objectives: To describe South African physiotherapists' …
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A reconfigurable electrode array for use in rotational electrical impedance myography
… (EIM), which is a method for diagnosing neuromuscular disease. The probe can be controlled from a PC via USB and uses an array of small electrode cells that can be connected together into larger electrodes with the help of crosspoint switches. A measurement system capable of fast …
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Hardware and software for hand-held electrical impedance myography measurement prototype system
… objective, and non-invasive method of neuromuscular disease assessment. Currently, the best solution to this problem requires large, bulky pieces of equipment and the time-consuming placement of numerous individual electrodes. In this thesis, a new hardware device and its corresponding …
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Flexure-Based Device Enables Precise Quantitative Monitoring of Muscle Performance
… a wide variety of clinical applications such as neuromuscular disease modeling and drug therapy testing. The contractile mechanisms of engineered muscle are often quantified by constraining the muscle on an elastomeric scaffold and measuring the scaffold’s deformation; however, structural …
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Characterization of Cardiomyopathy in a Mouse Model of Duchenne Muscular Dystrophy (DMD) Using Echocardiography, DCE-CT, and PET-FDG
… dystrophy (DMD) is an X-linked recessive neuromuscular disease that is the result of a loss of functional dystrophin, which causes cardiomyocyte fibrosis and death, leading to cardiomyopathy. In this thesis, I have utilized dynamic contrast-enhanced computed tomography (DCE-CT), positron …
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A Soft Robotic System for Mechanical Assistance to the Diaphragm
… the inspiration effort. Phrenic nerve trauma or neuromuscular disease can generate severe diaphragm dysfunction that ultimately leads to respiratory failure. The current treatment for patients with severe diaphragm dysfunction is permanent airway tethering to mechanical ventilation, which greatly …
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Cognitive aspects of chronic fatigue syndrome
… with depressed patients and patients with neuromuscular disease, as they share similar symptoms, but not diagnosis. This study attempts to compare four groups including a normal working group. A new measures was developed and piloted, designed to measure interpretations of symptoms in CFS. …
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Assessment of Electrode Configurations of Electrical Impedance Myography for the Evaluation of Neuromuscular Diseases
… a painless, noninvasive approach to measure the neuromuscular disease status. EIM parameters- resistance (R), reactance (X) and phase (θ) depend significantly on subcutaneous fat thickness, muscle size and inter electrode distance. The objective of this research is to find an electrode …
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Expression of genetic peripheral neuropathies in South African Children
… prevalence of 1:2500-1:10000. However, these diseases are under-reported and poorly understood in African populations. Definite, probable and suspected genetic peripheral neuropathy cases, were characterized from children based in an African setting. A hospital based retrospective …
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Psychological Aspects of Ventilator Dependent Children
… children (due to sleep apnea, neuromuscular disease, and acute physical injury) make up one such group of individuals. The current study assessed a group of home-based, ventilator-dependent children for symptoms of depression and posttraumatic stress. It was found that there was …
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SPINAL MUSCULAR ATROPHY ORGANOIDS REVEAL DEVELOPMENTAL DEFECTS RESCUED BY ANTISENSE OLIGONUCLEOTIDES TREATMENT
Spinal muscular atrophy (SMA) is a neuromuscular disease caused by mutations in the SMN1 gene. Recent therapies have significantly modified SMA natural course, but treatment efficacy remains variable and the reasons beyond this variability are still largely unexplored. Identifying pre-symptomatic …
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Admittance control of the intelligent assist robot manipulator for people with duchenne muscular dystrophy
Duchenne muscular dystrophy (DMD), a neuromuscular disease with a prevalence of 1 in 3500 male births, results in characteristic muscle weakness which is progressive with age and leads to loss of independence. And, in this population, maintaining optimal quality of life depends on the preservation …
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Identification of a first in-class integrin enhancing small molecule for the treatment of Duchenne Muscular Dystrophy
… dystrophy (DMD) is a catastrophic X-linked neuromuscular disease that affects 1 in every 5000 males. DMD is caused by mutations in the dystrophin gene which results in the loss of dystrophin protein, an essential link between the extracellular matrix and the actin cytoskeleton. This leads to …
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The role of recombinant human laminin-111 in adhesion-signaling and glycosylation in laminin-⍺2 deficient muscle
… dystrophy (LAMA2-CMD) is a rare and severe neuromuscular disease characterized by progressive muscular degeneration. LAMA2-CMD is caused by mutations in LAMA2 which encodes for the laminin-α2 protein. Loss of laminin-α2 results in the absence of laminin-211/221, an extracellular matrix …
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Complex thoracic malformations: is there an association between adolescent idiopathic scoliosis and pectus excavatum?
… with AIS. Patients with syndromic scoliosis, neuromuscular disease or incomplete radiographs were excluded. The PE severity index (Haller Index = HI) was determined. Multivariate logistic regression was applied to HI, Cobb angle, sex and age. To define the interclass correlation for the HI a …
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The Development and Use of an Intraoral Force Transducer in the Diagnosis and Treatment of Myasthenia Gravis
Myasthenia gravis is a neuromuscular disease characterized by variable weakness following voluntary muscle exertion. Because responses to the disease vary considerably between muscle groups, as well as between stages of the disease, diagnosis sometimes becomes a difficult and subjective evaluation. …
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MicroRNAs in ALS: Defining Cell-Type Specific Expression, Developing Methods to Modulate MicroRNAs in vivo, and Identifying Novel Therapeutic Targets
… lateral sclerosis (ALS) is an adult-onset, fatal neuromuscular disease with no adequate therapies. MicroRNAs (miRNAs) are dysregulated in a variety of disease states, suggesting that this newly discovered class of gene expression repressors may be viable therapeutic targets. A microarray of miRNA …
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Immune and stress factors in the pathophysiology of the mdx mouse model of Duchenne Muscular Dystrophy
… Muscular Dystrophy (DMD) is a fatal multi-system neuromuscular disease caused by loss of dystrophin. The loss of dystrophin from membranes of contractile muscle cells and the dysregulation of the DAPC, induces chronic inflammation due to tissue necrosis and eventual replacement with collagen which …
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