Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 42 for “"neuromodulators"”.
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The design, synthesis, and biological evaluation of aplysinopsin analogs as potential neuromodulators
Aplysinopsins are tryptophan-derived natural products that have been isolated from a variety of marine organisms and have been shown to possess a range of biological activities. Initial synthesis of a library of 50 aplysinopsin analogs revealed that of the 12 serotonin receptor subtypes and 34 …
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Translation and transcription are required for endogenous bursting after long term removal of neuromodulators
… pyloric activity after prolonged elimination of neuromodulators, translation inhibitors are tested on the recovery process of pyloric activity in C. borealis. In vitro experiments are conducted; the STG is exposed to the protein synthesis inhibitor Cycloheximide (CHX) and the transcription …
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Biophysical mechanisms of frequency-dependence and its neuromodulation in neurons in oscillatory networks
… properties, how MPR properties are modified by neuromodulators and how such modifications may lead to distinct functional effects at different network frequencies. In the first part of this dissertation it is demonstrated that, despite the extensive variability of individual ionic currents in a …
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Chemical Genetic Interrogation of Neural Stem Cells: Phenotype and Function of Neurotransmitter Pathways in Normal and Brain Tumor Initiating Neural Precursor Cells
… patients presumed to be chronically taking neuromodulators similar to those identified in the initial screen. Lastly, by further exploring the phenotype and function of neurotransmitter pathways in purified populations of human NSCs, I determined that neurotransmitter pathway gene expression …
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Silicon processing for microfluidic neuroprobes
… subjects, a neuroprobe capable of extracting neuromodulators with high temporal and spatial resolution and high chemical sensitivity and selectivity is needed. In addition, the overall dimensions of the probe must be minimized to limit brain tissue damage. This thesis describes the fabrication …
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Neural Mechanisms of Decision-Making: Modulation of the Feeding Neural Network by Nitric Oxide and Serotonin in the Predatory Marine Snail Pleurobranchaea Californica
… potential roles and mechanisms of two endogenous neuromodulators, the signal molecule nitric oxide (NO) and the biogenic amine serotonin (5-HT), in regulating the activity within the feeding neural network in Pleurobranchaea californica, a predatory sea slug that makes stereotypic feeding and …
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Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
A variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the …
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Neuropeptidomics Across Metazoan Life
… that neuropeptides, acting as neurotransmitters, neuromodulators and peptide hormones, play pivotal roles in a variety of physiological processes, such as learning and memory, sleeping, pain, and anxiety. To understand how neuropeptides work in the human brain can be extremely challenge; …
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Effect of low endogenous brain-derived neurotrophic factor levels on striatal dopamine dynamics
… a result of alterations with neurotransmitters, neuromodulators, and/or proteins. Specifically, one protein that has been linked to numerous neurological diseases and disorders such as Parkinson's disease, Huntington's disease, addiction, attention deficit hyperactivity disorder (ADHD), and …
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Differentiating noise and modulators in artificial neural networks
… which are postulated to be produced by neuromodulators such as neuropeptides. The findings of this study are that random noise does, indeed, enhance the operation of coarse-grain neural models; and that a 'neuropeptidergic' analogue also enhances operation; but to a different extent, and …
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Fabrication of Hybrid Optical Electrical Platforms for Potential Applications in Neuromodulation
<p>State-of-the art neuromodulators are bulky, and they are mostly fabricated on rigid substrates. Furthermore, they are not provided with a feedback control loop re- sulting in undesired off-target effects. This thesis paves the way for fabrication of lightweight neural interfaces with the …
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Nebulized Hypertonic Saline-Triggered Increase in Mucociliary Clearance Rate is Mediated by the Nervous System
… The next step will be to test the effects of neuromodulators in vivo using swine, or possibly even in human CF patients.
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Neuromodulation Based Control of an Autonomous Robot
… the sensory signals from the environment. These neuromodulators influence a vertebrate’s behaviors like focusing attention, cautious risk-aversion and curiosity-seeking exploration. The main objective of this thesis was to study and implement a neuronal model inspired by the neuromodulatory …
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Effect of Melatonin and Dopamine in Site Specific Phosphorylation of Phosducin in Intact Retina
… of light adaptation. Dopamine and melatonin are neuromodulators whose concentrations in the retina vary reciprocally during the circadian cycle, with dopamine high during the day and melatonin high during the night. Together, they control numerous aspects of light and dark adaptation in the …
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Genetic and Neural Circuit Analyses of Sickness and Foraging Behaviors in C. elegans
… of the specific mechanisms by which neuromodulators alter circuit function to drive context-relevant and stable behavioral states remains limited. In this thesis, we provide new insights into the neuromodulation and neural circuit control of long-lasting behavioral states by focusing …
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Encoding and Processing of Accessory Olfactory System Odorants
… can be regulated by noradrenaline and other neuromodulators. Despite years of targeted research, there are only a few known ligands for this system limiting our ability to understand how odorants are processed. Part of my thesis has focused on the discovery of novel ligands for this system. I …
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A systemic analysis of the ideas immanent in neuromodulation
… description of neuromodulation. Furthermore, neuromodulators are thought to underpin a distinct set of functional roles. Hence, a second contribution has been to define these in terms of a set of dynamical motifs. Subsequently the major goal of thesis has been to investigate the relationship …
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Mechanisms of ionic current changes underlying rhythmic activity recovery after decentralization
… changes, a novel role of central neuromodulators and of the cell-to-cell communication within the network in maintaining ionic current levels and their coordinations was demonstrated. Finally, the involvement of the two mechanisms of network plasticity, namely extrinsic …
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Regulation of voltage-gated K+ currents in motor neurons: activity-dependence and neuromodulation
… of minutes and is a relatively fast process. Neuromodulators exert long-term effects on ionic currents via activation of cellular signaling pathways that do not directly affect ionic current levels. Neuromodulation and activity-dependent effects can alter neuronal networks on different time …
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Investigation of the Signaling Mechanisms of the Pineal Hormone Melatonin in the in Vitro Rat Suprachiasmatic Nucleus
… but that melatonin has interactions with several neuromodulators, such as NPY, PACAP, and cAMP. Furthermore, there are at least two different melatonin receptors identified in the rodent SCN, the MT1 and MT2 receptors. Using specific antagonists against the MT2 melatonin receptor, it was …
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