Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 40 for “"neuromodulator"”.
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Intrinsic Properties and Neuromodulator Regulation of Neuronal Excitability of Intralaminar Thalamic Neurons
The parafascicular nucleus, one of the intralaminar thalamic nuclei, projects to many nuclei of the basal ganglia and several widespread neocortical areas. The parafascicular nucleus may have a role in arousal and motor activity. Based on morphological and electrophysiological properties, I found …
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Neurotransmitter and Neuromodulator Analysis Using Capillary Electrophoresis With Laser -Induced Fluorescence Detection
A variety of results on these neurotransmitters/neuromodulators have been elucidated using CE-LIF methods. Experimental results of the D-Asp study are consistent with the hypothesis that D-Asp is involved in cell to cell communication in Aplysia californica. In addition, D-Glu is found in the …
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The Impact Of The Inhibitory Neuromodulator Agmatine On Microglia Function In The Contexts Of Pain And Addiction
… properties of agmatine, an inhibitory neuromodulator in therapeutic development for chronic pain and opioid use disorder.
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Investigating the effects of aging and the neuromodulator retinoic acid on neurite outgrowth in a novel CNS organ culture
Neurite outgrowth is a critical process for nervous system regeneration following injury. However, aging impairs this process through changes in calcium handling, neurotransmitter sensitivity, and energy metabolism. In this thesis, I investigated agerelated changes in neurite outgrowth using a …
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SOCIAL ENVIRONMENT MODULATES THE FUNCTION AND NEUROENDOCRINE REGULATION OF ELECTROCOMMUNICATION SIGNALS ACROSS SPECIES OF APTERONOTID FISHES
… steroid hormones and gene expression for several neuromodulator receptors in electrosensory brain regions. Semi-social A. leptorhynchus chirped more than the other species. Males chirped more in A. leptorhynchus and in A. albifrons. Chirping was sexually monomorphic in A. balaenops. While …
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Pharmacological and Genetic Effects of Serotonin on Value-Based Decision-Making
This doctoral thesis investigated the role of the neuromodulator serotonin on four different value-based decision making tasks, using an acute tryptopahin intervention and an associative genetic approach - a naturally occuring variation in the promoter region of the serotonin transporter gene …
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Investigating Mechanisms In Nociceptors Driving Ongoing Activity and Ongoing Pain
… acutely in nociceptors were unknown for any neuromodulator, as were the neurophysiological alterations that underly ongoing activity in nociceptors after deep tissue incision. The work presented in this dissertation sought to identify a cellular signaling pathway and injury- and …
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Neural Sequences Underlying Directed Turning in C. elegans
… of this sensorimotor behavior across time. The neuromodulator tyramine coordinates these sequential brain dynamics. Our results illustrate how neuromodulation can act on a defined neural architecture to generate sequential patterns of activity that link sensory cues to motor actions.
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Serotonin (5-HT) Increases Olfactory Responsiveness in the Tobacco Hawkmoth Manduca sexta
… the functional role of serotonin (5-HT), a neuromodulator,on olfactory behavioral responses. In this study, we aimed to identify the functional role of 5-HT in Manduca sexta olfactory function. Using a Pavlovian-Conditioning Paradigm, we conditioned moths to 2-hexanone and tested them using …
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Cholinergic Control of Cortical Circuit Activity
… to be widely viewed as a slow and diffuse neuromodulator, despite the preponderance of in vivo evidence demonstrating rapid cholinergic function. In this study, we used a combination of optogenetics and in vitro electrophysiology to examine spatiotemporally precise control of cortical …
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Encoding and recall of memory for reward location in the mouse hippocampus
… consumption, are affected by acetylcholine – a neuromodulator released predominantly during movement and exploration. The findings highlight how acetylcholine modulates hippocampal state and how, when experimentally altered, it can impede memory encoding. Hippocampal activity facilitates …
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Novel Electrochemical Methods for Human Neurochemistry
… there remains a knowledge gap with respect to neuromodulator dynamics in humans. Recent efforts by members of the Montague Laboratory and collaborators adapted fast scan cyclic voltammetry (FSCV) from rodent experiments for use in human patients already receiving brain surgery. The process of …
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The Role of Retinoic Acid in the Formation and Modulation of Invertebrate Electrical Synapses
… insights into how retinoic acid can act as a neuromodulator of electrical synapses. My findings suggest that retinoic acid is capable of rapidly altering the strength of electrical synapses in a dose- and isomer-dependent manner. Further, I provide evidence that this acute effect might be …
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The effects of cholinergic and dopaminergic neurons on hippocampal learning and memory processes
… of learning and memory are modulated by these neuromodulatory systems. Using optogenetic stimulation or silencing, this thesis aims to investigate the effects of cholinergic and dopaminergic modulation on various hippocamal learning and memory processes. To understand how these neuromodulatory …
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Alterations In The Mouse Striatum Following Acute And Repeated Ethanol Exposure
… neurotrophic factor (BDNF) is an important neuromodulator that has implicated in regard to several neurological disorders, including alcohol addiction. BDNF is also an important modulator of dopamine (DA), a neurotransmitter that is heavily implicated in addiction with one of the DA rich …
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Modeling the hippocampus : finely controlled memory storage using spiking neurons
… The model included the important effects of the neuromodulator Acetylcholine that switches the hippocampal network between the memory encoding state and the memory retrieval state. In the first study, I examined the mechanisms for controlling runaway excitation in the model. The results indicated …
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Genetic and Neural Circuit Analyses of Sickness and Foraging Behaviors in C. elegans
… of the specific mechanisms by which neuromodulators alter circuit function to drive context-relevant and stable behavioral states remains limited. In this thesis, we provide new insights into the neuromodulation and neural circuit control of long-lasting behavioral states by focusing …
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Serotonin-Mediated Sickness Behavior
<p>Serotonin is an ancient and powerful neuromodulator that regulates diverse processes from fundamental physiology to complex emotions. Due to the many functions of serotonin distributed throughout the body and brain, governing principles of serotonin signaling have remained elusive. There is …
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Mechanisms of ionic current changes underlying rhythmic activity recovery after decentralization
… conditions, in particular after the removal of neuromodulatory input to this network (decentralization). For this purpose, changes in ionic currents during the process of network activity recovery after decentralization were studied. The previously unreported phenomenon of coordinated expression …
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The Neuroinflammatory Effects of Chronic Unpredictable Stress on Zebrafish, Danio rerio
… brain areas related to reward and aversion, the neuromodulator dopamine (DA), and DA’s critical role in mediating behaviors used to meet survival needs. </p> <p> In this study, we used the zebrafish to model PSTD by implementing a chronic unpredictable stress paradigm to simulate a traumatic …
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