Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 131 for “"neuromodulation"”.
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Wireless tools for neuromodulation
… and chronic nature of epilepsy. Most tools for neuromodulation in rodents are tethered. The few wireless devices use batteries or are inductively powered. The tether restricts movement, limits behavioral tests, and increases the risk of infection. Batteries are large and heavy with a limited …
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New technologies for neuromodulation
Non-invasive neural stimulation techniques are of increasing importance as devices move from the lab to the clinical environment. One such technology-transcranial magnetic stimulation-has already made the transition and is currently used by clinicians to treat depression. This device has several …
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Targeting Cholinergic Neuromodulation in Stroke Recovery
… this task I used it to investigate the role of neuromodulation on stroke recovery. The results of these studies show that NB cholinergic cells in the mouse are necessary for typical recovery from stroke, and increasing their activation during successful rehabilitation movements may improve …
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Muscle Recruitment Mechanism under Optogenetic Neuromodulation
Neurological conditions in which the communication pathway between the central nervous system and the peripheral neuromuscular components is severed, such as spinal cord injury, affect motor control, limiting patients’ overall quality of life. Functional electrical stimulation (FES) is the most …
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Neuromodulation Based Control of an Autonomous Robot
… presents a control approach based on vertebrate neuromodulation and its implementation on an iRobot Create platform. Three of the built-in sensors, namely, bump, dock beam, and battery state of Create were used in this study. In addition to these, five ultrasonic ping sensors were mounted in the …
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Neuromodulation in Experimetal Animal Models of Epilepsy
Epilepsy is the most common serious brain disorder affecting 0.5-1% of the general population. This neurological disorder consists of recurrent seizures, resulting from excessive, uncontrolled electrical activity in the brain. Despite the pharmacological development of new treatments, still one …
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Neuromodulation of Inhibitory Activity in Thalamocortical Circuits
In last chapter, I demonstrate that the inhibitory currents arising from interneurons and TRN neurons can be distinguished by their kinetics. The local interneurons are of interest because these neurons have two distinct outputs: axonal and dendritic. These cells have classical axonal outputs, …
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Emerging Bioelectronic Devices and Methods for Neuromodulation
… with biology. In this thesis, two types of neuromodulation devices - the electrophoretic drug delivery device and the spinal cord stimulator were investigated. The working principle of these devices were identified and represented as governing equations. Subsequently, strategies to optimize …
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Low-Intensity Ultrasonic Neuromodulation of the Rat Hippocampus
… a wide range of techniques for non-invasive neuromodulation have been proposed, the conventional approaches suffer from significant limitations. Most notably, focal stimulation of deep brain regions is presently only possible with invasive optogenetic and chemogenetic approaches that require …
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Stability of thin-film PEDOT:PSS electrodes for neuromodulation
… long-term stability has yet to be proven in neuromodulation applications where electrical stimulation over months to years is desired. This thesis addresses this critical challenge. An accelerated aging platform enabled high-throughput screening of various electrode configurations. Metal-free …
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A General-Purpose Software Platform for Closed-Loop Neuromodulation
<p>Implementing closed-loop neuromodulation therapies is a challenging and expensive endeavor. It requires developing software capable of acquiring signals from a bio-signal amplifier, analysis of these signals, and initiation of precisely timed stimulation, all of which need to be accomplished in …
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A systemic analysis of the ideas immanent in neuromodulation
This thesis focuses on the phenomena of neuromodulation — these are a set of diffuse chemical pathways that modify the properties of neurons and act in concert with the more traditional pathways mediated by synapses (neurotransmission). There is a growing opinion within neuroscience that such …
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Multisite optical neuromodulation : invention and application to emotion circuits
A single neural circuit, such as the network of neural populations involved in learning, expressing, and regulating fear, may spread across many brain regions and show functional heterogeneity among spatially overlapping cell types within each region. These populations, represented as discrete …
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Enhancement of verb retrieval: Neuromodulation, repetition priming, and aphasia rehabilitation
… it’s plasticity to behavioral training and to neuromodulation. In this thesis, I study mechanisms of language facilitation in healthy individuals and mechanisms of language recovery in individuals with aphasia. I use both behavioral modification techniques (repeated naming in healthy …
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Neuromodulation and neural circuits underlying cognitive flexibility in the rat
… of experimental approaches to interrogate the neuromodulation of the direct and indirect pathways by DA. In chapter 4, I found dissociable effects of D1 and D2 receptor antagonists during different stages of serial visual reversal learning when administered into the nucleus accumbens shell. In …
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A wireless communication link for a miniature, implantable neuromodulation system
Neuromodulation is a promising treatment for a variety of otherwise intractable medical conditions. Current neuromodulation devices are large, single-purpose, and limited in functionality. Draper developed a novel, implantable neuromodulation system to address these shortcomings. The system is …
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Advancing Transcranial Focused Ultrasound for Noninvasive Neuromodulation of Human Cortex
… ultrasound in both clinical and scientific neuromodulation applications, we sought to advance the use of low intensity focused ultrasound for noninvasive, transcranial neuromodulation of human cortex. This dissertation contains novel research on the use of low intensity transcranial focused …
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