Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 103 for “"neurological disease"”.
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The role of AUTS2 in neurodevelopment and neurological disease
… AUTS2 has been implicated in a wide variety of neurological and neurodevelopmental disorders, including autism, epilepsy, cognitive impairment, and Attention Deficit Hyperactive Disorder (ADHD). Additionally, single nucleotide polymorphisms (SNPs) in the AUTS2 locus are associated with …
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Machine Learning Applications For Neurological Diseases
Neurological conditions affect the brain and other parts of the nervous system. This includes neurodegenerative diseases like Huntington’s Disease, psychiatric conditions like schizophrenia, and brain cancers like glioblastoma. These conditions are particularly challenging to study because they …
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Neuropsychological Correlates of Borderline Personality Disorder
… those participants with a BPD diagnosis and a neurological disease performed worse on the measure of general neuropsychological functioning compared with individuals with BPD who had no history of a diagnosed neurological disease. Results from ANCOVA analyses revealed that significant …
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Neuropsychological Correlates of Borderline Personality Disorder
… those participants with a BPD diagnosis and a neurological disease performed worse on the measure of general neuropsychological functioning compared with individuals with BPD who had no history of a diagnosed neurological disease. Results from ANCOVA analyses revealed that significant …
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Protective effects of Human Bone Marrow-Derived Mesenchymal Stem Cells on Apoptosis Induced Human Neuroblastoma SH-SY5Y Cells
… strategies are crucial in treatment of neurological disorders including Alzheimer…s disease, Parkinson…s disease and stroke. Cell therapy using human bone marrow-derived mesenchymal stem cells (hMSCs) is an attractive tool to alleviate neurological disease We investigate whether culture …
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Developing Deep-Learning Methods for Diagnosis and Prognosis of Pediatric Progressive Diseases Using Modern Imaging Techniques
… manifestations form a significant burden of disease in young children. There have been efforts to correlate the neurological disease state in tuberous sclerosis complex (TSC) neurological disease state with imaging findings is a standard part of patient care. However, such analysis of …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
… When PrP misfolds, it aggregates and causes neurological disease and death in mammals. The structure of the non-pathogenic isoform has been determined while the structures of the disease related isoforms are unknown. The nitration labeling patterns of three PrP isoforms with peroxynitrite and …
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Probing Isoforms of the Prion Protein through Tyrosine Nitration
… When PrP misfolds, it aggregates and causes neurological disease and death in mammals. The structure of the non-pathogenic isoform has been determined while the structures of the disease related isoforms are unknown. The nitration labeling patterns of three PrP isoforms with peroxynitrite and …
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Timing recombinant prion protein conversion as a measure of prion activity in chronic wasting disease
Chronic Wasting Disease (CWD) is a fatal neurological disease affecting cervids caused by prions. Infected cervids shed the CWD prion in bodily fluids and excrement, contaminating the environment and creating an agricultural and ecological calamity. Preclinical antemortem CWD testing method is …
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Vocal modulation features in the prediction of major depressive disorder severity
… in sustained vowels as a basis for biomarkers of neurological disease, particularly Major Depressive Disorder (MDD). Two model components contribute to amplitude modulation (AM): AM from respiratory muscles and from interaction between formants and frequency modulation in the fundamental frequency …
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Comparative evolution of mipafox-induced delayed neuropathy in the rat and hen
… in humans have led to research regarding this neurological disease. Among the OPIDN-inducing agents is mipafox, an organophosphate insecticide, the compound we chose to employ in our studies. Although the hen is the primary experimental model in the safety assessment of organophosphates, …
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The Expression of Shuni Virus Nucleocapsid Protein in Nicotiana benthamiana for Use as a Diagnostic Reagent
… soon identified as a possible cause for cases of neurological disease in horses within South Africa. Studies have shown South African veterinarians who had come into contact with such cases tested positive for antibodies against the virus. Therefore, SHUV is being further investigated as a …
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Cache Valley Virus: A Comparison Across Both Lineages and Reassortant Strains Using in vitro and in vivo Models
… as headache, fever, nausea and in severe cases, neurological disease such as encephalitis, meningitis, and organ failure. Four human fatalities have been documented to date. CVV is endemic to North America and has been detected in mosquito, wildlife, and human samples across Canada, United …
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Investigating the host-microbe dialogue in aging
… in the context of aging and life stage related diseases. The focus was maintained on key inter-kingdom signalling molecules, host produced but bacterially modified Bile acids (BAs) and on dietary microbially derived Fatty acids (FAs) as key elements to indicate gut microbial potential impactful …
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Unique gene expression profiles of microglia and astrocytes following innate immune activation
… are often activated in association with diseases of the central nervous system (CNS), including virus-induced neurological disease. Understanding how activation alters the transcriptome of these cells may offer valuable insight in regards to how activated cells mediate neurological …
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Community mobility and physical activity participation in individuals with mulitple sclerosis
… examining activity levels in individuals with neurological disease (n=43). The pedometers significantly under-estimated counts in this group. 2. The test-retest reliability of the Physical Activity Scale for the Elderly (PASE) was examined. People with MS (n=20) were found to have low activity …
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Targeting Cognitive Impairment in Parkinson’s Disease: Novel Pharmacological and Non- Pharmacological Approaches
Whilst Parkinson’s disease (PD) is primarily characterised as a motor disorder, non-motor symptoms represent a significant burden to the PD population. These symptoms include anxiety, depression, fatigue and cognitive impairment (CI), with CI representing the single biggest predictor of quality of …
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Cardiovascular Reactivity to and Recovery from Laboratory Tasks in Low and High Worry Women
… and to increased risk of cardiovascular disease. Previous research on the anxiety-cardiovascular system relationship, including data from Knepp and Friedman (2008), are included to support this project. Two experiments were completed during the course of this study. The first consisted of …
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Med12 Is A Critical Regulator of Neural Crest Lineage and Nervous System Myelination
… module subunit directly implicated in human disease and is genetically altered in neurological disease and cancer. Numerous attempts at generating an<em> in vivo</em> system to study the role of Med12 failed due to embryonic lethality associated with germline or developmental disruption of …
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Effects of Proton Radiation on Behavior in a Mouse Model of Alzheimer’s Disease
… particle radiation that has been shown to cause neurological deficits in rodents via oxidative stress, neuroinflammation, altered neurogenesis, and synaptic changes. Since these responses are similar to those observed in age-related neurodegenerative diseases, we hypothesized that individuals …
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