Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"neuroligins"”.
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Neuroligins Determine Synapse Maturation and Function
Dieses Projekt untersucht die Rolle von Neuroliginen im Atmungsnetz des Hirnstamms von NL 1-3 und NL 2 herkömmlicher Knockout Mäuse. Die Auslassung aller drei Neuroligin- Gene führt zu einem lebensgefährlichen Phänotypus, der am wahrscheinlichsten einen Atmungsausfall bedingt, wie wir in unseren …
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N-linked glycosylation is fundamentally linked to the surface expression of neuroligins
N-linked glycosylation is one of the most prevalent forms of post-translational modification, decorating secreted and cell-surface transmembrane proteins as they are trafficked along the secretory pathway. While well-characterized in most tissues, non-canonical N-glycan diversification has been …
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Role of Neuroligin in Synapse Formation and Autism
Neuroligins mediate synaptogenesis through formation of a trans-synaptic complex with presynaptic neurexins. Interaction of neuroligin 1 with neurexins is regulated by alternative splicing of both neuroligin 1 (at splice site B) and of neurexins (at splice site #4). Full-length neuroligin 1 that …
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Molecular mechanisms of synaptic proteins
… following chapters, the SAMs neurexins (NRXNs), neuroligins (NLGNs), MDGAs, and immunoglobin superfamily 21 (IgSF21) are introduced. In our studies, we characterize how the structure-function relationships of SAMs and their interactions within the synaptic cleft could be regulated. We demonstrate …
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Molecular mechanisms of synaptic proteins
… following chapters, the SAMs neurexins (NRXNs), neuroligins (NLGNs), MDGAs, and immunoglobin superfamily 21 (IgSF21) are introduced. In our studies, we characterize how the structure-function relationships of SAMs and their interactions within the synaptic cleft could be regulated. We demonstrate …
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Neurologin Function in Excitatory and Inhibitory Synapses
Neuroligins (NLs) are postsynaptic cell adhesion molecules which by binding to presynaptic neurexins (NRXs) are thought to mediate synapse formation and function. Both NLs and NRXs are discussed in the genetic correlation to Autism. Over-expression of NLs could induce the formation of synaptic …
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A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in <i>C. elegans</i>
… the transthyretin-related gene <i>ttr-33</i>. Neuroligins are transmembrane proteins involved in the development and function of synapses. We provide evidence that <i>glit-1</i> and the previously identified tetraspanin <i>tsp-17</i> are associated with the regulation of dopamine turnover, …
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Identifying mechanisms of pyrethroid resistance in the navel orangeworm and novel methods of control
… acetylcholinesterases, gliotactins, glutactins, neuroligins, and neurotactins through phylogenetic and functional analyses. I discovered 64 total COEs in the A. transitella genome and placed them all into their corresponding subfamilies by constructing a phylogeny with Bombyx mori, Plutella …