Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 15 of 15 for “"neuroligin"”.
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Neuroligin: Charakterisierung eines neuronalen Transmembranproteins
… sind maßgeblich Zelladhäsionsproteine beteiligt. Neuroligine sind postssynaptisch lokalisierte Transmembranproteine. Sie bilden mit beta-Neurexinen transsynaptische Zelladhäsionssysteme, deren Lokalisation und Eigenschaften darauf hindeuten, dass diese an der Steuerung der Synapsenentstehung …
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Role of Neuroligin in Synapse Formation and Autism
Neuroligins mediate synaptogenesis through formation of a trans-synaptic complex with presynaptic neurexins. Interaction of neuroligin 1 with neurexins is regulated by alternative splicing of both neuroligin 1 (at splice site B) and of neurexins (at splice site #4). Full-length neuroligin 1 that …
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Regulation of Oligodendrocyte differentiation through Neuroligin-Neurexin signalling
The neuroligin (NL) gene family has been well characterized in neurons by virtue of its role as a synaptic cell adhesion molecule, and because mutations in the gene have been associated with Autism Spectrum Disorder (ASD). However much less is known about its role in the glial cell population, …
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Molecular Pathogenesis of Autism: A Role for Neurexin and Neuroligin
… the search for candidate genes. Neurexin and neuroligin, trans-synaptic ligands for each other, are two families of synaptic cell-adhesion molecules that have been linked to ASD pathogenesis. I found that three different mouse models for ASDs, the neurexin-1α deletion, the neuroligin-3 (NL3) …
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Elucidating the neural circuitry underlying social spacing in Drosophila melanogaster through the lens of neuroligin 3
… through the lens of Autism-candidate gene neuroligin 3. Based on the Nlg3 enrichment pattern in adult fly brains, I hypothesized that nlg3-expressing neurons, along with the mushroom bodies and protocerebral bridge, were involved in this behaviour. I determined that all the aforementioned …
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A transthyretin-related gene and a neuroligin-like gene prevent 6-hydroxydopamine-induced dopaminergic neurodegeneration in <i>C. elegans</i>
… (6-OHDA) uptake and isolated the neuroligin-like gene <i>glit-1</i> and the transthyretin-related gene <i>ttr-33</i>. Neuroligins are transmembrane proteins involved in the development and function of synapses. We provide evidence that <i>glit-1</i> and the previously identified …
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Neuroligins Determine Synapse Maturation and Function
Dieses Projekt untersucht die Rolle von Neuroliginen im Atmungsnetz des Hirnstamms von NL 1-3 und NL 2 herkömmlicher Knockout Mäuse. Die Auslassung aller drei Neuroligin- Gene führt zu einem lebensgefährlichen Phänotypus, der am wahrscheinlichsten einen Atmungsausfall bedingt, wie wir in unseren …
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Effects of Neuronal Nogo-A on Properties of Excitatory Synapses of the Sensorimotor Cortex
… plasticity at the excitatory synapse, including Neuroligin-1, NMDA receptor subunits NR2A and NR2B, and PSD-95. We found that mRNA of Neuroligin-1 and NR2B was substantially reduced, with no changes to NR2A or PSD-95 expression. These results suggest that neuronal Nogo-A may act to maintain …
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Effects of MDGA2 Reduction on Synaptic Long-Term Depression and Development in Male Mice
… excitatory synaptogenesis by inhibiting neurexin-neuroligin adhesion complexes and BDNF/TrkB signaling. Mdga2+/- mice, modeling autism-associated mutations, show increased excitatory synapse density and hyperexcitation in adulthood, resulting in altered hippocampus-dependent cognition and …
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N-linked glycosylation is fundamentally linked to the surface expression of neuroligins
… the importance of N-linked glycosylation for the neuroligin family of synaptic cell-adhesion molecules (NLGN1-4). NLGNs play a crucial role in regulating synaptic transmission strength by recruiting neurotransmitter receptors to synapses. Mutation of N-glycosylated residues increased retention of …
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Enzyme mediated labeling of synaptic proteins for proteomics and imaging
… the trans-synaptic interaction of the neurexin-neuroligin complex across the synaptic cleft, and 2) an "eraser" for LpIA based probe ligation.
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A TALE OF TWO NEUREXINS: NRX-1 AND NLR-1 FACILITATE FUNCTION OF MONOAMINE CIRCUITS AND FORAGING BEHAVIORS
… with an epistatic genetic interaction with nlg-1/neuroligin, a canonical binding partner of neurexins. I also find that nlr-1 controls responses to food and food deprivation by acting in different populations of neurons to promote or inhibit foraging activity, with nlr-1 acting in dopaminergic …
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Enzyme-mediated labeling of proteins and protein-protein interactions in vitro and in living cells
… to imaging of the interaction of PSD-95 and neuroligin-1, two proteins involved in synaptic maturation, in neurons.
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Visualizing synaptic orientation using super-resolution localiazation microscopy
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-12-01
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LEPTIN SIGNALING IN AN ANIMAL MODEL OF ANOREXIA NERVOSA: EVIDENCE FOR (MAL)ADAPTIVE PLASTICITY IN REWARD- AND COGNITIVE-RELATED BRAIN AREAS
… che, insieme a livelli ridotti di PSD95 e Neuroligin-1, indicano una riorganizzazione delle strutture sinaptiche ippocampali. In concomitanza con questa alterazione strutturale, abbiamo osservato un aumento della localizzazione delle subunità dei recettori NMDA e AMPA sia nella densità …