Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 13 of 13 for “"neuroinvasive"”.
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Counteracting Neuroinvasive RNA Viruses: Antiviral and Immune Modulation Strategies Against SARS-CoV-2 and VEEV
The global response to the COVID-19 pandemic and our inability to mitigate spread of SARS-CoV-2 has highlighted areas of research that warrant further study. RNA viruses have since been at the forefront for pandemic and prevention preparedness due to their increased potential to cause future …
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Long-term Consequences of West Nile Virus in Virginia.
… of Health with West Nile virus (WNV) non-neuroinvasive and neuroinvasive disease. The study identified the duration of symptoms after initial illness, the number of persons who fully recovered versus the number who continue to be symptomatic and how patients' quality of life differed after …
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Phenotypic Characterization of Mutations Made to the Envelope Protein of West Nile Virus
… mosquito-borne flavivirus that can cause severe neuroinvasive disease resulting in death or long term neurological sequela. The envelope (E) protein of flaviviruses has three domains and is the major component of the virion surface, with the EIII being the putative receptor binding domain. …
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THE ROAD LESS TAKEN: CHARACTERIZING THE TRIGEMINAL NERVE ROUTE OF NEUROINVASION BY RESPIRATORY SARS-COV-2
… serve as an additional, yet often overlooked, neuroinvasive route. We initially conducted a pilot study using AC70 human ACE2 transgenic mice, which were subjected to intranasal inoculation of SARS-CoV-2, to investigate the olfactory nerve route of neuroinvasion. We incidentally found the …
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Phylogenetics and New Approaches to Vaccine Development for West Nile
… American isolates were also found to be highly neuroinvasive and neurovirulent and in many cases leading to mortality or permanent CNS sequelae among humans. WNV was first isolated in Louisiana in 2001. The genome of this virus named LSU-AR01was sequenced and a detailed genetic analysis revealed …
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Cross-protection from St. Louis encephalitis virus and Usutu virus disease by human West Nile virus convalescent plasma in mice
… febrile disease and, in some cases, severe neuroinvasive diseases, especially among the elderly or immunocompromised individuals. Due to their co-circulation in the same geographical areas and sharing similar hosts and vectors, individuals in Italy and Germany have been detected as …
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From Entry to Dysfunction: SARS-CoV-2 Neuropathogenesis in Peripheral Sensory and Autonomic Neurons and Its Implications
… (PNS) became common, suggesting the virus may be neuroinvasive. These observations prompted studies to determine how SARS-CoV-2, the causative virus, invades the nervous system. Early studies focused exclusively on CNS invasion and found that SARS-CoV-2 infects sustentacular cells and olfactory …
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Characterizing the Cellular Response to Astrovirus Infection in the Central Nervous System
… have recently been identified as neuroinvasive pathogens capable of inducing neurological diseases. This study explores the cellular and molecular mechanisms by which AstV, specifically non-classical VA1 and classical HAstV1 genotypes, induce CNS pathology in human neurons and …
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Genotypic and Molecular Determinants in the Continued Evolution of West Nile Virus in the United States
… revealed a relationship between an attenuated neuroinvasive mouse phenotype and low genetic diversity in natural WNV quasispecies structure. These in silico results and prior applications of the Harris Co. paradigm identified several natural mutations encoded in the NS4B protein—a protein that …
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The Impact of Powassan Virus and Borrelia burgdorferi Coinfection in Ixodes scapularis Ticks
… of the United States. Powassan virus can lead to neuroinvasive illness with a high fatality rate. B. burgdorferi causes Lyme disease, a potentially long-term infection of the joints, heart and brain. B. burgdorferi is present in 20-70% of ticks, while POWV is present in less than 5%. This suggests …
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Neurological Consequences of Viral Encephalitis: Behavioral Deficits, Neuronal Restructuring, and Therapeutic Interventions
… Venezuelan equine encephalitis virus (VEEV), a neuroinvasive alphavirus that causes severe neurological symptoms, including seizures and encephalitis, with no available treatments or vaccines. Despite its significant public health implications, including its potential as a biological weapon, …
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West Nile virus vaccination protects against Usutu virus disease in mice
… asymptomatic, but in severe cases can cause neuroinvasive disease. WNV and USUV belong to the JEV serocomplex group, which indicates that antibodies produced against these viruses share a common antigen; the common antigen is hypothesized to be the envelope (E) protein on the outside of the …
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Matrix Gene Splicing and Emergence of Highly Pathogenic Avian Influenza
… American wild bird gene segments, they became neuroinvasive and highly virulent in mammalian animal models. To date, this outbreak has resulted in culling almost 60 million commercial poultry. Our results determined that these viruses, although virulent in mammals, retained mostly avian …