Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"neurogenin"”.
-
Roles of Neurogenin and Geminin in Vertebrate Neurogensis
Roles of neurogenin and geminin in vertebrate neurogenesis Proneural basic helix-loop-helix transcription factors regulate cell fate commitment and differentiation in neurogenesis. However, their proneural functions are not well understood, in part due to a lack of information about their target …
-
Covalent modification and intrinsic disorder in the stability of the proneural protein Neurogenin 2
Neurogenin 2 (Ngn2) is a basic Helix-Loop-Helix (bHLH) transcription factor regulating differentiation and cell cycle exit in the developing brain. By transcriptional upregulation of a cascade of other bHLH factors, neural progenitor cells exit the cell cycle and differentiate towards a neuronal …
-
Unraveling the neurogenin/ngn-1 gene regulatory network of C. elegans using classical genetics and comparative transcriptomics
… most essential in governing early neurogenesis. Neurogenins are a family of such factors that are both sufficient and necessary for the development of neural sub-types in mice, primarily through the regulation of other factors, particularly NeuroD. The objective of this study was to evaluate …
-
Function analysis of Xenopus NumbL in the context of primary neurogenesis
… und wird durch die proneuralen Faktoren der Neurogenin Familie induziert und durch Notch inhibiert. Während die Überexpression von NumbL zu einer leichten Zunahme postmitotischer Neuronen führt, inhibiert ein Knockdown von NumbL alle molekularen Marker stromabwärts von Neurogenin und führt zu …
-
Validating ngn-1 transcriptome targets in C. elegans
… and can affect a multitude if genetic targets. Neurogenins (Ngns) are a class of deeply conserved basic-helix-loop-helix transcription factor required for fate specification of multiple neuron types and brain structures. Despite its importance in nervous system development and function, the …
-
Identification and Functional Characterization of Novel Genes Involved in Primary Neurogenesis in Xenopus laevis
… durch den proneuralen Faktor X-Neurogenin related-1 (X-Ngnr-1) aktiviert und durch laterale Hemmung reprimiert wurden. Eine vergleichende Expressionsmusteranalyse zeigte, dass XPak3, aber nicht XPak1 und XPak2, eine neuronal exprimierte XPak Isoform ist. Interessanterweise …
-
Artificial neural network and precision genome engineering frameworks for genetic system engineering in mammalian cells
… derivatives generated using GATA6-mediated and Neurogenin-mediated directed differentiation. The sensor provides a fluorescent readout based on the activity of a specific miRNA with single-cell resolution, and has applications in organoid engineering and basic research. The machine learning …
-
Investigating β- and γ-secretase function and processing of APP with genetic and pharmacological tools
… and glia-specific markers. I also show that Neurogenin-2, a protein indirectly regulated by the same enzymes that process APP, can be used to improve the differentiation capacity of both cell types.
-
Master regulators of neuronal maturation in NGN2 reprogrammed iPSC-derived iNeurons
… takes advantage of the recent discovery that Neurogenin 2 (NGN2) overexpression in induced pluripotent stem cells results in their rapid conversion into excitatory induced neurons (iNeurons) that are morphologically complex and electrophysiologically active after 2 weeks in culture. In …
-
Integrative genomic analysis of Neurogenin2 reprogramming of human iPSCs
… concepts of cellular identity. The expression of Neurogenin 2 (NGN2) results in rapid reprogramming of human pluripotent stem cells (PSCs) into functional excitatory neurons. My lab has previously demonstrated that gene targeting the components of a Tet-On system overexpressing NGN2 into two …