Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"neurogenetics"”.
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Investigation into the Neurogenetics of Vocal Learning in Tursiops Truncatus, the Bottlenose Dolphin
… this behavior remains unknown. By studying the neurogenetics of vocal learning in intelligent mammals, we can gain a deeper understanding of the evolution of spoken language. As a first step in investigating the neurogenetic underpinnings of cetacean vocal learning, we generated a …
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Semantic and pragmatic language development in typical acquisition, autism spectrum disorders, and Williams syndrome with reference to developmental neurogenetics of the latter
The elucidation of the biological bases of a complex trait like human language proceeds from identification of precise behavioral phenotypes to investigation of the underlying genes. The human behavioral parts of this dissertation focus on understanding the reasons for children's overuse of …
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Heritable variation in reward sensitivity and impulsive cction and choice in a genetically diverse inbred mouse panel
… was conducted with the Center for Systems Neurogenetics of Addiction’s (CSNA) effort to characterize CC and DO mice for multiple, cocaine abuse related traits.</p>
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The Genetics Of Mosquito Heat-Seeking Behavior
… to be understood about the ethology and sensory neurogenetics of this notorious insect. In this thesis, we used high-throughput quantitative behavioral assays and genome-editing techniques to investigate the behavioral rules and molecular basis of mosquito thermotaxis. We have found that female …
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Identifying Neural, Genetic, and Behavioral Correlates of the p Factor
… I first investigate these correlates in the Duke Neurogenetics Study (DNS) comprised of 1,246 young adult volunteers aged 18-22. I then determine whether the correlates identified in the DNS replicate in a subsample of 481 45 year-old members of a birth cohort from the ongoing Dunedin Longitudinal …
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EXPANSION OF CLINICAL PHENOTYPE AND USE OF KETOGENIC DIET IN RARE GENETIC CONDITIONS: GLUCOSE TRANSPORTER TYPE 1 DEFICIENCY SYNDROME AND SCN8A-RELATED DISORDERS
… for functional studies, and the Center for Neurogenetics at the University of Texas, Health Science Center in Houston (USA) for computational analyses. The study focused on the clinical analysis of individuals carrying loss-of-function (LoF) variants. Variant selection followed a rigorous …
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The role of germline and somatic nuclear and mitochondrial DNA variation in neurodegenerative disorders
Neurodegenerative disorders are a group of age-related conditions resulting in neuronal cell death and protein accumulation. It is estimated that around 5-10% of these cases are genetically mediated. Most commonly this is by pathogenic single nuclear variants (SNVs), though combinations of rare …
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Genetic dissection of circuits underlying the modular structure of the Superior Colliculus
In order to successfully interact with the environment, animals need to produce accurate movements towards specific positions in space. A crucial region of the brain that guides such goal-oriented movements is the superior colliculus (SC), an evolutionary conserved structure of the midbrain. While …
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Transposable Elements in Neural Progenitor Cells
More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is …
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Visualization and manipulation of microRNA in neural cells
microRNA (miRNA) are small non-coding RNA, 21-23 nucleotides long. miRNA provide a new layer of regulatory control over gene expression programs. It is increasingly evident that miRNA are cell type and tissue specific. Many miRNAs have been identified to be highly abundant in certain regions of the …
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Genetic Testing Practices of Genetic Counselors, Geneticists, and Pediatric Neurologists With Regard to Childhood-Onset Neurogenetic Conditions
<p>Identifying genetic diagnoses for neurological conditions with a considerable hereditary component, such as autism spectrum disorder (ASD), intellectual disability, and epilepsy, is critical to providing proper medical management for these patients and their families. However, many patients with …
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Molecular and Cellular Investigations of Prader-Willi Syndrome
<p>Prader-Willi syndrome (PWS) is a complex multigenic neurodevelopmental disorder resulting in hypotonia, developmental delay, hypogonadism, sleep dysfunction and childhood onset obesity affecting 1 in 10,000 to 30,000 individuals. PWS is an imprinting disorder that is caused by a loss of …