Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 298 for “"neurogenesis"”.
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Engrams, Neurogenesis, and Forgetting
… work from our lab has shown that hippocampal neurogenesis promotes forgetting in both infants and adults. In project 3, the mechanism underlying neurogenesis-mediated forgetting was explored. Multiple transgenic mouse lines were used that granted bidirectionally control over the extent to …
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Function of MCPH1 in Neurogenesis
Primäre Mikrozephalie (MCPH) ist eine autosomal-rezessive Krankheit, die charakterisiert ist durch eine kleine Gehirngröße, wobei der zerebrale Kortex am stärksten betroffen ist. MCPH wird verursacht durch Mutationen in einem von sieben MCPH Genen: Microcephalin, WDR62, CDK5RAP2, CEP152, ASPM, …
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Impact of adult hippocampal neurogenesis on behavior
The role of adult hippocampal neurogenesis in behavior, especially contextual fear conditioning (CFC), is debated. Several studies demonstrated that blocking adult hippocampal neurogenesis in rodents impairs CFC, while several other studies failed to observe impairment. We sought to determine …
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The Role of Adult Neurogenesis in Cocaine Addiction
… of administration changes long-term effects on neurogenesis. In addition, it is unclear what role if any SGZ neurogenesis plays in initiating drug-taking or relapse behaviors, or whether changes in neurogenesis are merely side effects of drug-taking. I first examined effects of chronic cocaine …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG …
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Roles of HDACs and MEF2 in Adult Hippocampal Neurogenesis
… hippocampal NSPCs can provide insight into basic neurogenesis principles important for tissue homeostasis and preventing tumor formation. Pharmacological inhibition of histone deacetylases (HDACs), a class of histone-modifying enzymes, have promising effects in cancer cells, yet the specific roles …
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The Role of Adult Hippocampal Neurogenesis in Morphine Addiction
… neuroplasticity within the hippocampus is adult neurogenesis, which occurs in the subgranular zone of the dentate gyrus. While a growing amount of literature has explored the effects of drugs of abuse on adult DG neurogenesis, the relationship between self-administered opiates and adult DG …
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Innate immunity in Zika Virus infection and neurogenesis deficits
… brain, and how ZIKV targets NS/PCs to cause neurogenesis reduction. In this project, I developed a mouse model to explore the role of microglia in ZIKV dissemination to the fetal brain, and used human NS/PC (hNS/PC) lines to determine the role of innate immune genes in neurogenesis reduction …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
Neurogenesis in the adult mouse brain occurs within the subventricular zone (SVZ) of the lateral ventricle. In the SVZ, neural stem cells (NSC) reside in a specialized microenvironment, or vascular niche, consisting of blood vessels and their basement membranes. Most NSCs in the SVZ differentiate …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… It has been shown that stroke leads to increased neurogenesis, birth of new neurons, within the brain. This increased neurogenesis is not sufficient to restore lost function. There is a need to develop therapies for neuronal replacement by improving neurogenesis within the brain and / or …
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Functional analysis of transcription factor mScrt2 in cortical neurogenesis
Der Neokortex ist eine für das Säugerhirn spezifische Struktur, die schichtartig das Vorderhirn umschließt. Er zeichnet sich durch eine enorme Zellvielfalt aus, die aus der räumlich-zeitlich koordinierten Generierung mehrerer neuronaler und glialer Zelltypen hervorgeht. Die Mehrheit aller …
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ADDUCINS AFFECT CORTICAL NEUROGENESIS BY REGULATING PROGENITORS¿ MORPHOLOGY AND FATE
Human intellectual abilities largely depend on the expansion of the mammalian cerebral cortex, the brain region responsible for cognition, reasoning, language and so much more. Across evolution, neocortex expanded massively, reaching a critical size in human. The main reason for this change can be …
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The Role of Notch1 in Adult Hippocampal Neurogenesis and Function
Neurogenesis occurs throughout life in the hippocampal subgranular zone (SGZ) and is potently stimulated by exercise, but the underlying mechanisms are still poorly defined. Notch1 is a master regulator of developmental neurogenesis, yet its role in adult hippocampal neurogenesis is unclear. To …
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The Role of Glutamate Transporters in Early Postnatal Hippocampal Neurogenesis
Adult neurogenesis has been well-characterized in the subgranular zone (SGZ) of the hippocampal dentate gyrus however, early postnatal development of the dentate gyrus and changes in the neurogenic niche during this time have not been well-studied. Using a well-characterized transgenic mouse that …
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Transcriptional Regulation of Adult Neurogenesis by NRSF/REST and NeuroD1
Neurogenesis in the adult brain is a complex and lifelong process that is regulated by multiple pathways and is sensitive to many external stimuli. Two critical regulatory factors in this process are NRSF/REST and NeuroD1. NRSF/REST, a transcriptional repressor that binds a specific NRSE site and …
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The Impact of Opioids and Opiates on Adult Hippocampal Neurogenesis
… of chronic morphine on different stages of neurogenesis showed that chronic morphine decreased numbers of Type 1 stem cells and proliferating progenitor cells. Progenitor cells exposed to chronic morphine during early maturation were not significantly decreased in number, but appeared to …
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