Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"neurofilament light"”.
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Neurofilament light chain
… Fall-Kontroll-Studie untersuchte den Biomarker Neurofilament light chain (NfL) bei Patient*innen mit Status epilepticus. Zu den zentralen Fragestellungen gehörte der Vergleich mit neurologisch gesunden Kontrollen, die Unterscheidung zwischen verschiedenen Statusformen sowie die prognostische …
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Evaluation of Neurofilament Light Chain as a Biomarker in Dogs with Structural and Idiopathic Epilepsy
… prospective cohort study is to assess the use of neurofilament light chain (NfL) as a biomarker for diagnostic and therapeutic monitoring in dogs with idiopathic and structural epilepsy. A total of 50 dogs (36 idiopathic epilepsy and 14 structural epilepsy) were enrolled to contribute a total of …
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The role of neurofilament-light polipeptide (NEFL) in the onset and progression of hepatocellular carcinoma
… Recently, it has been shown that NEFL gene (Neurofilament-light polypeptide), whose mutations are responsible of motor-neuron disease such as Charcot-Marie-Tooth disease type 2E, is also involved in some types of malignancies. However, no information about NEFL and HCC are available. Aim: Aim …
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Evaluating Magnetic Resonance Imaging and Serum Markers As Surrogate Endpoints for Clinical Trials in Cerebral Small Vessel Disease
… interest in circulating biomarkers such as serum neurofilament light chain as they are easier to obtain from patients than imaging markers and as they can be centrally computed also in multicenter trials. The thesis aim is to evaluate imaging as well as circulating biomarkers as surrogate …
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Molecular mechanisms of radial axonal growth : insights from analysis of neurofilament gene-targeted mice
… the axon and the expression of proteins known as neurofilaments (NFs) within the axon. NFs are cytoskeletal proteins composed of neurofilament light (NF-L), medium (NF-M) and heavy (NF-H) subunits. It was not well understood how NF subunits mediate the radial growth of axons. To investigate, I …
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Blood and Lumbar Fluid Biomarker Changes in Patients with HIV-Associated Neurocognitive Impairment Treated with Lithium: Analysis from a Randomised Placebo-Controlled Trial
… Investigated biomarkers included dopamine, BDNF, neurofilament light chain, and CD8+ lymphocyte activation (CD38+ HLADR+). Alzheimer's Disease (AD) biomarkers included soluble amyloid precursor protein alpha and beta (sAPPα/β), Aβ38, 40, 42, and ten other biomarkers validated as predictors of mild …
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PLASMA JNK3 AS A NOVEL PERIPHERAL BIOMARKER IN ALZHEIMER'S AND PARKINSON'S DISEASES: EARLY DIAGNOSIS AND DISEASE MONITORING
… symptom severity and were more sensitive than neurofilament light chain (NfL) in identifying early disease stages. Unlike NfL, JNK3 did not correlate with age in pathological groups, further supporting its specificity. Importantly, JNK3 was quantified using a commercially ELISA kit, …
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Neuromuscular Dysfunction as a Novel Indicator for Alzheimer's Disease and Response to Intervention in the 5xFAD Model
… of AD-like pathology, such as amyloid- beta and neurofilament light chain. In a separate cohort, we treated 3-month-old 5xFAD mice with donepezil or placebo daily for 4 weeks and assessed similar outcomes. Our data show that both interventions delay neuromuscular impairment from 3 to 4 months but …
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Sex Differences in the Relationship Between Physical Activity and Cognitive Health in Ethnically Diverse Older Adults
… were obtained: amyloid-beta (Aβ)40, Aβ42, neurofilament light, total tau, and pTau-181. Hippocampal and subregion volumes and dorsolateral prefrontal cortex thickness were measured. Analysis of covariance was performed to examine the interaction between PA group, sex, and ethnicity for each …
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Prediction value of genetic and neuromarkers in blood and liquor in patients with severe traumatic brain injury
… Fibrillary Acid Protein (GFAP, CSF, study IV), Neurofilament light (NFL, CSF, study IV), Tau (CSF, study II), β-amyloid (1-42) and amyloid precursor-proteins (CSF & plasma, study I) were enhanced after a sTBI. Further, we investigated if these levels were correlated to outcome, neurology and …
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Different approaches to biomarker research for ALS: in search of novel neuronal markers associated with extracellular vesicles
… research. Of all the proposed biomarkers, neurofilament light chain (NfL) is the most promising, having been demonstrated to be useful as both a diagnostic and a prognostic and pharmacodynamic biomarker. In this thesis, various strategies were implemented to study biofluids collected from …
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An overview of blood-based biomarkers in AD
… glial fibrillary acidic protein (GFAP) and neurofilament light chain (NFL)) in two different cohorts. Our results have indicated that Aβ1-42/Aβ1-40 ratio, p-tau181 and GFAP levels are reliable biomarkers for identifying individuals with ongoing brain amyloidosis and could also be used in a …
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Diagnostic Methods in Traumatic Brain Injury
… III tested whether a novel blood biomarker, neurofilament light (NFL), could identify DAI, and study IV tested whether a microwave technology (MWT) device, designed for use also in a prehospital setting, could detect intracranial hematomas. Patients and methods: In study I, MR-DTI of the …
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Visual Outcome Measures of Remyelination and Neuroprotection in Multiple Sclerosis
… and time required to conduct. Finally, serum neurofilament light chain (NfL), global fibrillary acidic protein (GFAP) and Tau blood biomarkers were not responsive indicators of treatment efficacy in the Cambridge Centre for Myelin Repair study One (CCMR-One), a Phase IIa randomised, controlled …
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The influence of acute, chronic and lifelong hypoxia on the functional and structural integrity of the neurovascular unit
… glial fibrillary acidic protein [GFAP], neurofilament light-chain [NF-L] and total-tau [T-Tau] determined via automated clinical grade ELISA and Single Molecule Array technology). Cardiopulmonary variables included mean arterial pressure (MAP), heart rate (HR), stroke volume (SV), cardiac …
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Characterizing neurodegeneration, neuroinflammation and immunological status through multimodal strategies in type 1 diabetes mellitus and relapsing-remitting multiple sclerosis
… nerve fibre layer (RNFL) thickness. Serum neurofilament light chain (sNfL) and glial fibrillary acidic protein (GFAP) were also measured. Both patient groups exhibited cognitive and mood disturbances and significantly elevated sNfL levels, indicative of early neurodegeneration, compared …
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Neuroprotective effects of the dual glycogen synthase kinase-3b and phosphodiesterase 7 inhibitor VP3.15 and of an enriched environment in germinal matrix-intraventricular hemorrhage
… cognitive outcomes associated with GM-IVH, highlighting their therapeutic potential in both preclinical and clinical contexts.