Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 15 of 15 for “"neuroendocrine tumors"”.
-
Gallium-68 DOTATATE PET/CT in Neuroendocrine Tumors
The general metadata -- e.g., title, author, abstract, subject headings, etc. -- is publicly available, but access to the submitted files is restricted to UT Southwestern campus access and/or authorized UT Southwestern users.
-
Functional Analysis of Daxx In Tumorigenesis of Pancreatic Neuroendocrine Tumors and Embryonic Development
… have revealed the importance of DAXX in human tumors. Mutually exclusive mutations in DAXX and ATRX occur in about 30% of pancreatic neuroendocrine tumors (PanNETs). Although lots of progress has been made in studying functions of DAXX, we still do not fully understand how DAXX functions as …
-
HISTONE LYSINE METHYLTRANSFERASE NSD3 GOVERNS TRANSCRIPTIONAL PROGRAMS THAT DRIVE PANCREATIC NEUROENDOCRINE TUMORS (PANNETS)
<p>Pancreatic Neuroendocrine Tumors (PanNETs) are the most common and lethal neuroendocrine malignancies where treatments used in advanced patients have limited efficacy, adverse side effects, and acquire resistance. Thus, there is a critical need to uncover novel precision therapeutics for PanNET …
-
Ligand-Directed Aavp to Deliver A Therapeutic Transgene to Neuroendocrine Tumors of The Pancreas
<p>Human pancreatic neuroendocrine tumors are rare tumors that form in the endocrine pancreas. Patients with these tumors have limited therapeutic options, and curative intervention is limited to surgical resection. These tumors do, however, consistently express somatostatin receptor type 2 (SSTR2) …
-
MOLECULAR MECHANISMS UNDERLYING CLINICAL BEHAVIOR OF NEUROENDOCRINE TUMORS: STUDY OF NEW POSSIBLE BIOMARKERS PREDICTABLE OF PHARMACOLOGICAL RESISTANCE AND TARGETS
Neuroendocrine tumors (NETs) represent a heterogeneous group of malignances arising from the diffuse neuroendocrine system whose incidence is rising over the years. Due to their complexity and unusual features, first-line therapeutical approach is represented by surgical resection, even if it is …
-
Specific diagnosis for effective treatment of neuroblastomas and pulmonary neuroendocrine tumors through transcriptional profiling-based interpretation of cellular development
… that neuroblastomas (NBs) and pulmonary neuroendocrine tumors (NETs), which are neoplasms of neural origin, are molecularly different based on their expression of regulatory genes and that exposure to extrinsic factors will alter their growth potential. Using reverse-transcription …
-
Structure-activity relationship of octreotide analogues labeled with rhenium and technetium-99m
… be used as diagnostic and therapeutic agents for neuroendocrine tumors, respectively. Several series of octreotide analogues that differ in their sequences, and/or coordination systems (S₂N₂ and S₃N) were developed. Their in vitro receptor binding affinity toward somatostatin receptors was …
-
Von Hippel-Lindau Syndrome: Characterization of a Potentially Novel VEGF-A Isoform and Elucidation of Molecular and Vascular Mechanisms of Observed Phenotypic Changes
… (HB), pheochromocytoma (PCC), pancreatic neuroendocrine tumors (PNET), pancreatic and renal cysts, and clear cell renal cell carcinoma (ccRCC). The disease process follows Knudson's two-hit model, requiring spontaneous loss or mutation of a normal VHL tumor suppressor allele to induce …
-
EXPLORING THE CROSSTALK BETWEEN POLO-LIKE KINASE 1 AND Eph-FAMILY OF RECEPTORS IN CELL DIVISION IN PANCREATIC CANCER MODEL
… ductal adenocarcinoma (PDAC) and Pancreatic neuroendocrine tumors (NETs). Between the two subtypes PDAC represent majority of the diagnosed disease with over 90% of the patients. PDAC is an invasive form of PC with an increased rate of cell division as well as more metastatic behaviour. This …
-
Somatostatin Receptor 2 Regulation By C-Terminal Motifs and Pdz Domain Proteins
… receptor that mediates many of somatostatin’s neuroendocrine actions. Sst2 is a clinically important GPCR as it is the drug target of somatostatin analogs such as octreotide, lanreotide, and pasireotide. Treatment with these agonists is the main medical approach to controlling excessive hormone …
-
Anti-Tumor Effects of The Notch Pathway In Gastrointestinal Stromal Tumors
<p>Gastrointestinal Stromal Tumors (GIST) are sarcomas driven by gain-of-function mutations of <em>KIT </em>or<em> PDGFRA</em>. Although, the introduction of tyrosine kinase inhibitors has dramatically changed the history of this disease, evidences emerge that inhibition of KIT<em> </em>or PDGFRA …
-
Multimodality Somatostatin Analog For Fluorescence-Guided Surgery In Cancer
… major therapeutic implications for patients with neuroendocrine tumors (NETs). Anatomical and functional imaging technologies are widely used during the pre- and postoperative stages, but intraoperative disease recognition relies on direct visual inspection and the hands of surgeons. The limited …
-
Characterizing ASCL1-Dependent Neuroendocrine Non-Small Cell Lung Cancers
… cancer, it is important to accurately classify tumors using a combination of factors, including patho-physiological features, tumor gene expression profiles, response to therapy, and oncogene/tumor suppressor mutation status. Gene expression analyses, including immunohistochemistry, single mRNA …
-
Analysis of ASCL1 in Neuroendocrine Lung Cancer
… is an understudied tumor subset with aggressive neuroendocrine carcinoma features. Previous studies have determined that the basic helix-loop-helix (bHLH) transcription factor achaete-scute homolog 1 (ASCL1) is essential for the survival and progression of many pulmonary neuroendocrine (NE) …