Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 8 of 8 for “"neuroendocrine differentiation"”.
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Characterization of Gene Expression During Adenosine 3':5'-Cyclic Monophosphate Induced Neuroendocrine Differentiation in Human Prostatic Adenocarcinoma
… transduction pathway can induce reversible neuroendocrine differentiation. Elucidation of those genes that are differentially expressed between undifferentiated prostate cancer cells and prostate cancer cells that have been induced to differentiate may present new insights for the molecular …
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Grk3 Connects Angiogenesis and Neuroendocrine Differentiation In Prostate Cancer By Activating Hdac2 That Epigenetically Represses Tsp1 and Rest
… cause of mortality in men in the United States. Neuroendocrine prostate cancer (NEPC) is the aggressive subset of castration-resistant prostate cancer (CRPC), found in ~20% lethal CRPC. The mechanisms underlying the progression of PCa to NEPC are still largely unclear, and new drug targets are …
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Expression of epithelial and neuroendocrine markers within canine apocrine gland anal sac adenocarcinoma (AGASACA) and the relationship to peripheral hypercalcemia and parathyroid hormone-related protein (PTHrP) expression
… of these masses and identified evidence of neuroendocrine differentiation within some canine anal gland tumors. At this time, however, the significance of this finding is unknown, though additional examination may reveal relationships between neuroendocrine differentiation and the occurrence …
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Neuroendocrine neoplasms of the digestive tract: retrospective classification according to the 2019 WHO grading system, and evaluation of the immunohistochemical marker INSM1
Neuroendocrine Neoplasms (NENs) of the Gastrointestinal Tract (GIT) are a heterogeneous group of tumours with varied biologic potential and clinical outcomes. They are classified as well differentiated neuroendocrine tumours (WD NET) or poorly differentiated neuroendocrine carcinomas (PD NECs) …
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Novel Mechanisms of Β-Adrenergic Signaling In Prostate Cancer Progression
… (CREB). Downstream targets of CREB activation in neuroendocrine differentiation as well as in neoangiogenesis are largely unknown, indicating that the underlying mechanisms of β-adrenergic signaling in prostate cancer progression are far from completely understood. For instance, while the …
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CaV1.3 Ion channel expression and hormone therapy in prostate cancer
… androgen-sensitive PCa and is associated with neuroendocrine differentiation. ENZ treatment promotes CaV1.3 plasma membrane localisation and functional expression in PCa subpopulations which may be worth therapeutic exploration.
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Defining oncogenic determinants in prostate cancer initiation and progression
… to an AR-null state and the acquisition of neuroendocrine differentiation remain largely unknown. We have delineated critical roles of the pioneer factors ASCL1 and NEUROD1 in neuroendocrine transdifferentitation and uncovered their abilities to silence AR expression and signaling by …
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The effect of cAMP elevation on intracellular signalling pathways in prostate epithelial cells
… with morphological changes consistent with neuroendocrine-like differentiation associated with terminal disease. PKA activation was required for cAMP-mediated changes in LNCaP cell morphology and could be recapitulated by reagents which inhibited RhoA/ROCK signalling, suggesting that cAMP …