Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 20 for “"neuroendocrine cells"”.
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Control of Neuroendocrine Cell Physiology by a Single Transcription Factor, Drosophila Basic Helix Loop Helix Regulator DIMMED
<p>Neuroendocrine cells feature a large capacity for the processing, accumulation and regulated release of bioactive peptides and peptide hormones. The ultrastructural correlate of this regulated secretory pathway is a specialized organelle, called a dense core vesicle: DCV). DCVs are typically …
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MUTATION OF THE VESICULAR MONOAMINE TRANSPORTER-1 GENE ALTERS ITS PROTEIN PRODUCT
… and serotonin, in secretory vesicles of neuroendocrine cells. Recently the VMAT1 protein was detected in human and mouse brain, and mutations of the VMAT1 gene at single DNA nucleotides (single nucleotide polymorphisms or SNPs) were associated with schizophrenia. In this study, Chinese …
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The development and evolution of vertebrate oxygen-sensing cells
Oxygen-sensing cells release neurotransmitters, including serotonin, in response to hypoxia in the blood or surrounding air/water. This stimulates the glossopharyngeal and/or vagal nerves, triggering increased ventilation via the respiratory reflex. In the adult, they are located in the carotid …
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Influenza A Virus Induced Programmed Cell Death
… IAV pathogenesis. These are (1) alveolar unit cells and (2) cells of the conducting airways, primarily those of the bronchi and bronchioles. Alveolar unit cells, or pneumocytes, chiefly comprise type I and type II alveolar epithelial cells, and are involved in gas exchange and surfactant …
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Sorting of Cargo Proteins Within the Regulated Secretory Pathway: the Peripheral Membrane Protein HID-1 as a Sorting and Vesicle Biogenesis Factor
… retention using selective hooks (RUSH) method in neuroendocrine cells, we show it is possible to visualize sorting to the constitutive and regulated secretory pathways in real-time and that the bulk of transmembrane LDCV cargoes do not sort directly onto LDCVs, but exit the TGN into non-regulated …
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Dynamics and Turnover of Lipid and Protein Domains in Cells and Supported Bilayers
… these clusters are sites of membrane fusion in neuroendocrine cells. Syx1a was measured using dynamic measurements (FRAP and single molecule tracking), first by looking at substrate dye interactions to ensure dynamics were not altered by unintended interactions between dye and substrate. …
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Time of Day Influences on Gonadotropin Releasing Hormone Neurons
… 1920's that the decapeptide released by these neuroendocrine cells is the fundamental driver of ovulation in mammalian females, understanding the regulation of its release has been an arduous affair. Neural afferents from all regions of the brain project to these neurons. While stress and …
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Investigating the initiation and progression of small cell lung cancer
… naphthalene, a chemical that ablates the cells that line the bronchioles of the lung. The pulmonary neuroendocrine cells, the putative cell of origin of SCLC, are refractory to naphthalene-mediated injury. We demonstrated that naphthalene-mediated injury prior to tumor initiation in the …
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Histone Lysine Demethylase KDM4A as a Therapeutic Target for Small Cell Lung Cancer
Small cell lung cancer (SCLC) arises from neuroendocrine cells within the lung. Along with deletion or loss-of-function RB1 and TP53 mutations, which occur in almost all cases, subsets of SCLC are driven by specific lineage transcription factors including ASCL1, NEUROD1, POU2F3, or YAP1. The …
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Psychoneuroimmunology of Interleukin-10
Appropriate interactions between the neuroendocrine and immune systems are important for optimal host defense and homeostasis. Pro-inflammatory cytokines such as interleukin-1, interleukin-6 and tumor necrosis factor-alpha, arising from disease processes, can activate the …
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Neuroendocrine neoplasms of the digestive tract: retrospective classification according to the 2019 WHO grading system, and evaluation of the immunohistochemical marker INSM1
Neuroendocrine Neoplasms (NENs) of the Gastrointestinal Tract (GIT) are a heterogeneous group of tumours with varied biologic potential and clinical outcomes. They are classified as well differentiated neuroendocrine tumours (WD NET) or poorly differentiated neuroendocrine carcinomas (PD NECs) …
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Topographische und funktionelle Charakterisierung des putativen Chaperons fls485
… proteins, their composition and interaction in cells, has become an important scientific topic since the decoding of the human genom. This thesis also examines a protein, fls485, whose genetic code was discovered in a RNA-Genechiparray on human enterocytes of the small intestine. The sequence …
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Characterizing ASCL1-Dependent Neuroendocrine Non-Small Cell Lung Cancers
… decades suggest that distinct, poorly performing neuroendocrine tumors occur in about 10% of otherwise pathologically indistinguishable non-small cell lung cancers. A complete molecular characterization of these tumors is lacking because no pre-clinical model exists. Utilizing genome-wide mRNA …
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Regulatory Proteins in Progenitors and Differentiated Cells of the Human Prostate
… proteins in mature and differentiating cells of the adult prostate, including the benign and malignant prostate. In this thesis, I provide evidence for epithelial renewal in response to prostate tissue culture, and for basal and epithelial stem cell (SC) recruitment leading to an …
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Transcriptional Regulation of kal-1 in the Nematode Caenorhabditis elegans
… also prevents gonadotropin-releasing hormone neuroendocrine cells from migrating to the pituitary, preventing the pulsatile release of sex hormones at puberty. While many <em>kal-1</em> interacting proteins have been studied in model organisms, little is known about the regulatory mechanisms …
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Sampling strategies for characterization of neuropeptides using mass spectrometry and functional implications into cell-cell signaling
… even from individually isolated magnocellular neuroendocrine cells, where vasopressin and several other peptides are detected. At the same time, it was shown that the same approach could be applied to analyze peptides isolated from a similar hypothalamic region, the suprachiasmatic nucleus …
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Serotonin 1A Receptor Signaling in the Hypothalamic Paraventricular Nucleus of the Peripubertal Rat
… of Akt but exhibited "full" agonist activity on neuroendocrine responses and activation of ERK. 5-HT1A receptors produce a rapid and prolonged activation of ERK in the peripubertal PVN, unlike the rapid but more transient response in the adult PVN. In addition, the 5-HT1A activation of ERK may be …
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Cell Biology of the ICA69 protein family in Neurosecretory cells
… insight into the secretory machinery of beta-cells and led to the discovery of novel pathways. Islet cell autoantigen of 69 kDa (ICA69) is a T1D autoantigen. It is a cytosolic protein of still unknown function. An impairment in neurotransmitter release upon mutation of its homologue in C. …
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Immunopathological and Structural Alterations in Difficult to Control Asthma
… hyperreactivity, including airway smooth muscle, neuroendocrine epithelial cells, and nerve fibres. In Paper IV, we show that bronchial thermoplasty treatment likewise has long-lasting immunological effects as evident by a reduction of key bronchial immune cells including mast cell populations and …