Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 93 for “"neurodevelopmental disorder"”.
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Impact of Neurodevelopmental Disorder-Associated Clinical Variants on the Catalytic Activity of KMT5B
… Missense variants found in KMT5B cause a related neurodevelopmental disorder in which patients experience neurodevelopmental phenotypes like developmental delay (DD), intellectual deficits (ID), autism spectrum disorder (ASD), seizures, and motor deficits. However, the impact of these variants on …
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Developmental trajectory of synaptic vesicle recycling in wild type and neurodevelopmental disorder mqodels
… for its operation are heavily implicated in neurodevelopmental disorders (NDDs). We addressed this gap in knowledge by determining the developmental trajectory of SV recycling pathways in wild type (WT) murine hippocampal neurons from primary cultures. Using the genetically-encoded calcium …
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Mouse Models of GRIN1-Related Neurodevelopmental Disorder and Initial Investigations of Endocannabinoid Modulating Treatments
… development, learning and memory. GRIN1-Related Neurodevelopmental Disorder (GRIN1-NDD), is characterized by clinically significant variation in the GRIN1 gene, which encodes the obligatory GluN1 subunit of NMDARs. Patients present with a wide range of symptoms of varying severity but nearly all …
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Mothers' lived experiences of caring for their child with HIV-related neurodevelopmental disorder/s
… HIV parents are reported to be at risk of having neurodevelopmental disorders (NDDs), which can reduce independence in activities of daily living by imposing varying limitations on these children. Technological advances in the field of HIV/AIDS have resulted in prolonged life for people infected …
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Exploring Family Resilience and Connectedness During a Pandemic in Families Raising a Child with a Neurodevelopmental Disorder
… (COVID-19), and those raising a child with a Neurodevelopmental Disorder (NDD) may be particularly vulnerable to negative consequences from the health catastrophe. Family resilience is a contributing factor to a family's strength in time of hardship and refers to the family’s “ability, as a …
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The endocannabinoid system in critical neurodevelopmental periods: Focus on its role in the pathophysiology of schizophrenia as neurodevelopmental disorder [Il sistema endocannabinoide nei periodi critici del neurosviluppo: Focus sul suo ruolo nella fisiopatologia della schizofrenia come disturbo dello neurosviluppo]
INTRODUZIONE: Il periodo intrauterino, l’infanzia e l’adolescenza sono periodi cruciali, in cui l'esposizione a diversi insulti (infezioni, sostanze d’abuso come la Cannabis, inquinanti ambientali, ecc.) combinata con fattori di rischio genetici potrebbe influenzare lo sviluppo del sistema nervoso …
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The Role of MeCP2 and FoxG1 in Embryonic Cortical Development: Implications for Autism Spectrum Disorders
Autism spectrum disorders (ASDs) represent a group of neurodevelopmental conditions characterized by impaired social interactions, communication difficulties, and repetitive behaviors. While the etiologies of ASDs are complex and heterogeneous, mounting evidence points to disrupted cortical …
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ST3GAL3 GENE MUTATION WITHIN THE SINGULAR NUCLEOTIDE POLYMORPHISM, RS3952787, POTENTIALLY COULD PREDICT ATTENTION DEFICIT HYPERACTIVE DISORDER, ANXIETY, AND DEPRESSION
<p>Certain disorders, like attention deficit hyperactive disorder (ADHD), are challenging to diagnose, particularly via clinical assessment, as the standard diagnostic criteria and testing methods vary among clinicians. ADHD is commonly known as a neurodevelopmental disorder, and as such, certain …
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BRAIN STRUCTURE AND FUNCTION ASSOCIATED WITH EMOTION DYSREGULATION IN TYPICAL DEVELOPMENT AND NEURODEVELOPMENTAL DISORDERS
… such as Attention-Deficit/Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) remained unclear. In two studies, neuroimaging techniques were employed to explore the association of ED with grey matter volume (GMV) and resting state functional connectivity (FC) in TD (study 1), …
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Deletion of FMR1 results in sex-specific changes in behavior.
Fragile X Syndrome (FXS) is a neurodevelopmental disorder caused by excessive trinucleotide (CGG) repeats in the FMR1 gene coding for fragile x mental retardation protein (FMRP). In humans, this disorder is characterized by intellectual disability, as well as other behavioral abnormalities, such as …
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Audiovisual multisensory integration in young adults with and without a diagnosis of Attention-Deficit/Hyperactivity Disorder
Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder with behavioural and neurophysiological characteristics. Several cortical structures that are altered in ADHD are involved in the process of multisensory integration (MSI). MSI is a fundamental form of sensory …
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Genetic Alterations Associated with Attention Deficit Hyperactivity Disorder
<p>Attention Deficit Hyperactivity Disorder (ADHD) is the most common neurodevelopmental disorder affecting children. Children with ADHD may have difficulty with maintaining focus and appropriate activity levels as well as controlling compulsive behaviors. Currently, the diagnostic criteria for …
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Motor and Phonic Tic Severity and Its Relationship to Social, Emotional, and School Functioning in Children With Tourette Syndrome From the Caregivers’ Perspective
<p>Abstract</p> <p>Tourette Syndrome (TS) is a neurodevelopmental disorder characterized by motor and phonic tics that is frequently associated with functional impairments. The present study examined the relationship between motor and phonic tic severity, comorbid conditions, academic …
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Discovery and Characterization of Rare Genomic Copy Number Variants in Children with Developmental Coordination Disorder
Developmental coordination disorder (DCD) is a common neurodevelopmental disorder characterized by functional motor performance deficits. Recent studies have demonstrated that the genetics of neurodevelopmental disorders can partially be explained by rare copy number variants (CNVs). To assess the …
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Adolescents with FASD: Education-Based Strategies for Social Skills Development
Fetal Alcohol Spectrum Disorder (FASD) is a permanent neurodevelopmental disorder characterized by physical, mental, and learning disabilities. Despite variability, individuals with FASD consistently struggle with acquiring appropriate social skills. Limited research has explored educational …
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The Efficacy of an In-Vivo Chaining Procedure Compared to POV-VM Chaining Procedure to Teach a Task to Children with Autism
<p>Autism Spectrum Disorder (ASD), is a neurodevelopmental disorder which includes symptoms such as repetitive or restricted patterns of behavior, and deficits in social communication (American Psychiatric Association, 2013) and affects approximately 1 in 68 children (Centers for Disease Control …
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FACTORS RELATED TO SEX DIFFERENCES IN AGE OF DIAGNOSIS OF AUTISM SPECTRUM DISORDER
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder that is characterized by deficits in social communication and the presence of repetitive and restricted patterns of behavior and interests. A rating of severity is also required when making a diagnosis. Early intervention has …
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FACTORS RELATED TO SEX DIFFERENCES IN AGE OF DIAGNOSIS OF AUTISM SPECTRUM DISORDER
Autism spectrum disorder (ASD) is a prevalent neurodevelopmental disorder that is characterized by deficits in social communication and the presence of repetitive and restricted patterns of behavior and interests. A rating of severity is also required when making a diagnosis. Early intervention has …
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A brain-derived MeCP2 complex supports a role for MeCP2 in RNA processing
… in MECP2 are linked to the severe postnatal neurodevelopmental disorder Rett Syndrome (RTT). To further understand MeCP2 and potential roles in RTT pathogenesis, we have employed a biochemical approach to identify the MeCP2 protein complexes present in the mammalian brain. Here we show that …
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Exploring Autistic Individuals’ Perspectives of Social Skills Interventions
<p>One in 44 children have autism spectrum disorder (ASD) (Maenner et al., 2021). ASD is a neurodevelopmental disorder in which individuals demonstrate marked deficits in reciprocal social communication and a pervasive pattern of restricted and repetitive behaviors or interests (American …
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