Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 172 for “"neurodegenerative disorder"”.
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Synaptic morphology, function, and regulation in a paediatric-onset neurodegenerative disorder
The mucopolysaccharidoses are a group of inherited metabolic diseases wherein undegraded substrate accumulates within lysosomes as a result of dysfunctional lysosomal protein. The most common sub-group is mucopolysaccharidosis (MPS) III (collectively 1 in 70,000). In Australia, MPS IIIA is the most …
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Study of Structural and Physical Properties of Small Molecule and Nanoparticle Inhibitors of Amyloid-B Protein Fibril Formation In Alzheimer'S Disease
<p>Alzheimer's disease (AD) is a progressive neurodegenerative disorder and the leading cause of dementia in the elderly. The instances of AD are rapidly increasing and there is no cure currently available for this devastating disease. Current therapies for the disease allow AD patients to delay or …
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Progress Towards Development Of Multifunctional, Dopamine D2/d3 Receptor Agonists As Symptomatic And Disease-Modifying Therapeutic Agents For Parkinson's Disease
<p>Parkinson¡¯s disease (PD) is a progressive, neurodegenerative disorder that arises primarily through the loss of dopaminergic neurons in the substantia nigra pars compacta (SNc), resulting in a diminished level of the neurotransmitter dopamine in the nigrostriatal pathway and ensuing loss of …
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THE RELATIONSHIP BETWEEN BRAIN AND SYSTEMIC METABOLISM IN ALZHEIMER’S DISEASE AS ASSESSED BY DUAL-TRACER ACETOACETATE/FLUORODEOXYGLUCOSE PET IMAGING
Alzheimer’s disease (AD) is a fatal neurodegenerative disorder that afflicts an estimated 5.4 million people in the United States. Cerebral metabolic dysfunction is a well-established feature of AD. Despite an established relationship between systemic metabolic disease and AD we know very little …
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A renewed vision for Amyloid beta and tau in Alzheimer s disease pathophysiology
… underlying Alzheimer s disease (AD), a neurodegenerative disorder affecting the elderly and characterized by memory loss, personality changes and cognitive dysfunction leading to dementia. I will discuss the main projects in which I participated aimed at understanding the role of the …
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Characterization of Vesicular Monoamine Transporter 2 and Its Role In Parkinson'S Disease Pathogenesis Using Drosophila
<p>Parkinson’s disease (PD) is a progressive neurodegenerative disorder caused by the selective loss of the dopaminergic neurons in the <em>S</em><em>ubstantia nigra</em><em> pars compacta</em> region of the brain. PD is also the most common neurodegenerative disorder and the second most common …
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The mechanism for paraquat toxicity involves oxidative stress and inflammation : a model for Parkinson's disease
Parkinson's disease (PD) is a neurodegenerative disorder known to affect the dopaminergic neurons in the substantia nigra. Epidemiological studies have shown an increased risk of developing PD with exposure to paraquat. In this study, we examined the source of reactive oxygen species (ROS) and the …
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Ethno-Racial Background and Risk for Parkinson’s Disease
… disease is the second-most common progressive neurodegenerative disorder in the world. Presently, there is a lack of evidence from large-scale multifactorial studies suggesting a definitive link between race/ethnicity and PD risk. In our research, we conducted a targeted literature review to …
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Oxidative stress biomarkers in dementia
Alzheimer’s disease (AD) is a devastating neurodegenerative disorder which is thought to affect 26.6 million individuals worldwide. There is growing concern over a worldwide dementia epidemic that is predicted to develop over the coming decades. The evidence thus far suggests that increased levels …
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Drp1 inhibition is protective against mitochondrial and autophagic impairment induced by alpha-synuclein
… disease (PD) is the second most common neurodegenerative disorder with currently no effective neuroprotective or neurorestorative treatments available. Alpha-synuclein (α-syn) pathology is one of the key proteins involved in PD pathology, it has been found to induce mitochondrial …
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Cell model of DJ-1-associated Parkinson’s Disease
Parkinson’s disease (PD) is a neurodegenerative disorder characterized by progressive loss of motor function resulting from dopaminergic neuronal death in the substantia nigra pars compacta leading to subsequent decreased striatal dopamine levels. The majority of PD cases are diagnosed as sporadic …
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Cytokine and neurotransmitter regulation of glial cell production of Il-6; indications for neurodegenerative disorders
… and swelling of the surrounding tissue. AD is a neurodegenerative disorder characterized by well-defined neuropathologic entities. Both IL-1 and IL-6 are present in senile plaques and may cause a self-propagating inflammatory process that contributes to the disease processes of AD; Somatostatin …
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Neuroprotective effects of overexpression of the inhibitor of apoptosis proteins in the quinolinic acid model of excitotoxic injury.
… disease (HD) is an autosomal dominant neurodegenerative disorder which results in the selective loss of the medium spiny neurons in the striatum. The neuropathological and behavioural deficits of HD can be modeled in rats by injection of the NMDA receptor agonist quinolinic acid (2,3 …
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The Effect of Grapes in Mice with Alzheimer's Disease and Brain Injury
<p>Alzheimer’s disease (AD) is a progressive neurodegenerative disorder resulting in cognitive and memory deficits and deposits of amyloid beta (Aβ) in the cortex and hippocampus are thought to be significant contributors to the disease process. Increasing evidence suggests that foods rich in …
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Systems Biology Approaches for Elucidating Early ALS Disease Processes
ALS is a devastating neurodegenerative disorder with no known cure. In this thesis, I describe high-throughput omics characterization of patient-derived induced pluripotent stem cell (iPSC) models. I present analyses aimed at discovering disease pathways and genes associated with ALS using systems …
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Unraveling dual dysfunction in Friedreich’s ataxia: how mitochondrial dysfunction and microglial activation drive neurodegeneration
… ataxia (FRDA) is hereditary recessive disorder that impacts muscular function at several levels. Currently 1 in 40,000 people are impacted by FRDA globally. FRDA is defined by multiple symptoms including progressive ataxia, dysarthria, sensory loss, cardiomyopathy, diabetes mellitus, …
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The Apoptotic and Wallerian Degeneration Pathways Regulate Disease Onset and Progression in the SOD-1G93A Transgenic Mouse Model of ALS
<p>Amyotrophic Lateral Sclerosis is a neurodegenerative disorder characterized by progressive muscle denervation, motor axon degeneration and the death of motor neurons. The molecular mechanisms that mediate axon degeneration in ALS remain unknown, but motor neuron cell body death occurs through …
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Impact of speech amplification devices on quality of life in persons living with Parkinson's disease and hypophonia : a quality improvement project
Parkinson's disease (PD) is a progressive, neurodegenerative disorder caused by reduced dopaminergic neurons of the brain that frequently cause speech and voice disturbances (Mohseni et al., 2023). Of the motor and nonmotor symptoms that develop in PD, tremor, speech difficulties, and muscle …
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The ALS Genes TDP-43 and FUS/TLS Regulate a Common Pathway in the Nervous System of Drosophila Melanogaster
Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disorder characterized by the dysfunction and death of motor neurons. Patients afflicted with this condition commonly experiences muscle weakness that progresses to generalized paralysis. Although most ALS cases are sporadic, mutations in …
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Integrating Omics data : a new software tool and its use in implicating therapeutic targets in Huntington's disease
… studies of Huntington's disease (HD), a fatal neurodegenerative disorder with no cure. By leveraging Omics Integrator on omics datasets from induced pluripotent stem cell (iPSC) derived models of HD, I discovered and highlighted several pathways that are altered in these cell line models, …
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