Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 20 of 1300 for “"neurodegenerative"”.
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Intravital diagnostics of neurodegenerative diseases
Prionopatie, taktiež nazývané transmisívne spongiformné encefalopatie (TSE), a synukleínopatie predstavujú skupinu neurodegeneratívnych ochorení, ktoré sú asociované s akumuláciou nesprávne zložených proteínov (prión a α-synukleín) prevažne v centrálnom nervovom systéme. Kvôli absencii spoľahlivého …
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Genetic Characterisation of Neurodegenerative disorders
… increasing number of elderly are affected with neurodegenerative diseases, including the subjects of the studies in this work, Alzheimer's disease (AD), Parkinson's disease (PD), progressive supranuclear palsy (PSP) and corticobasal degeneration (CBD). On strong evidence that several genes may …
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Connectivity biomarkers in neurodegenerative tauopathies
The primary tauopathies are a group of neurodegenerative diseases affecting movement and cognition. In this thesis I study Progressive Supranuclear Palsy (PSP) and the Corticobasal Syndrome (CBS), two parkinsonian disorders associated with accumulation of hyperphos- phorylated and abnormally folded …
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Markers of Prognosis in Neurodegenerative Dementia
… time of survival in the two most common types of neurodegenerative dementia; AD and DLB/PDD. Study populations: I. 142 patients with AD. II. 79 patients with AD and 49 patients with DLB. III. 30 patients with DLB/PDD. IV. 32 patients with DLB PDD. Results: I. Patients with very high T-tau levels …
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ML-assisted therapeutics for neurodegenerative disorders
Submission original under an indefinite embargo labeled 'Open Access'. The submission was exported from vireo on 2023-12-04 without embargo terms
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Detecting Multimodal Behaviors for Neurodegenerative Disease
Neurodegenerative diseases such as Parkinson’s and Alzheimer’s are incurable and affect millions of people worldwide. Early diagnosis is critical for improving quality of life for patients. Current methods rely on the use of tests administered and evaluated by clinicians. The digital Symbol Digit …
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Pathogenesis of Neurodegenerative Diseases via Templated Recruitment
A common feature of many neurodegenerative diseases is the deposition of filamentous protein aggregates in the central nervous system (CNS), including neurofibrillary tangles (NFTs) composed of tau, and Lewy bodies (LBs) consisting of α-synuclein (α-syn), which are the hallmark lesions of …
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Investigating neurodegenerative diseases with small molecule modulators
… of the mechanisms underlying cell death in neurodegenerative diseases has proven difficult, due to the complex and interconnected architecture of the nervous system as well as the often pleiotropic nature of these diseases. Cell culture models of neurodegenerative diseases, although seldom …
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miRNA expressione profiles in retinal neurodegenerative diseases
… una moltitudine di patologie, incluse patologie neurodegenerative. L'identificazione di un pattern di espressione del profilo di miRNA potrebbe essere utilizzato come un metodo innovativo per la scoperta di nuovi biomarcatori e lo sviluppo di nuovi target farmacologici nell'uomo. Lo scopo della …
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De-Risking PET Radioligand Discovery for Neurodegenerative Diseases
This work sought to characterize novel and existing radioligands, assessing their utility and effectiveness for positron emission tomography (PET) imaging of neurodegeneration. Three proteins were targeted: 1) colony stimulating factor-1 receptor (CSF-1R); 2) glycogen synthase kinase-3 (GSK-3); and …
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Functional and Pathophysiological-morphological Correlates of Neurodegenerative Diseases
This doctoral thesis pictures neurodegenerative diseases as a multilevel process, describes various correlates on each pathophysiological level, and presents selected correlates in Huntington's disease and mitochondrial membrane protein-associated neurodegeneration (MPAN). It uses various …
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Cytosolic sphingolipids and lysosome reactivation in neurodegenerative diseases
Glucosylceramide (GlcCer) is one of the simplest glycosphingolipids (GSLs) synthesized at the cytosolic face of cis-Golgi and translocated to the plasma membrane and organelle lumen. The glucocerebrosidases degrade GlcCer in the cytosol and lysosome. GlcCer has been suggested to be an activator of …
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Role of PACAP-ADNP axis in neurodegenerative process
… le sue proprietà neuroprotettive nelle malattie neurodegenerative, tra cui la Sclerosi Laterale Amiotrofica (SLA) e la Retinopatia Diabetica (RD). Le mutazioni nel gene che codifica per l’enzima superossido dismutasi Cu/Zn (SOD1) sono responsabili del 20% dei casi familiari di SLA. I meccanismi …
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Investigating Ageing of Neurodegenerative Disease Relevant Protein Condensates
… between dysfunctional proteins condensates and neurodegenerative disease pathogenesis complements the current research. Protein condensates often become pathological when their physical properties change, from a liquid state to a more gel-like or solid-like state. This process is referred to as …
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Modelling neurodegenerative diseases in human iPSC-derived neurons
Neurodegeneration is a pathology shared by a varied class of diseases, and many of the mutations that are known to cause such diseases have been linked to protein aggregation and autophagy dysfunction. Improvements to gene editing and neuronal differentiation strategies have enabled the derivation …
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The spread of pathological assemblies in neurodegenerative disease
Neurodegenerative diseases represent a significant burden on global health. Their incidence and prevalence are projected to increase dramatically over the next few decades. Yet no effective disease-modifying treatments exist, partly owing to our incomplete understanding of pathogenesis. It is known …
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Quantitative analysis of proteotoxicity associated with neurodegenerative disease
Neurodegenerative diseases are a costly burden, both economically and in terms of human suffering. A common feature of neurodegenerative diseases is that they stem from problems with protein folding, but the underlying biology that leads to neuron death is not well understood. Due to this lack of …
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Cannabinoids: A Novel Treatment Strategy for Retinal Neurodegenerative Disorders
<p>Synthetic and naturally occurring cannabinoids are known to decrease intraocular pressure (IOP). Glaucomatous damage to the retina and optic nerve progresses even after therapy to maintain normal intraocular pressure (IOP). Topical application of cannabinoids decreases IOP while not affecting …
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Transcriptomic studies of protein homeostasis perturbations in neurodegenerative disorders
… was then extended to a broader family of neurodegenerative disorders associated with the aggregation of tau protein, which is a hallmark of AD and other diseases, in order to underline the importance of the balance between key molecular mechanisms in combatting the disease progression. The …
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Microwave sensing and imaging for early detection of neurodegenerative diseases
L'abstract è presente nell'allegato / the abstract is in the attachment
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