Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 51 for “"neurochemistry"”.
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Novel Electrochemical Methods for Human Neurochemistry
… of this work challenge existing assumptions of neurochemistry, while demonstrating the capabilities of new neurochemical sensing approaches. This study will also act as a springboard for emerging technological developments in human neurochemistry.
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Monitoring brain neurochemistry after brain trauma
This thesis investigates the development and implementation of advanced mid-infrared spectroscopic sensors and attenuated total reflection (ATR) fibre optic probes for real-time monitoring of cerebral metabolites in traumatic brain injury (TBI) patients. Through a series of in-vitro and in-vivo …
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Pesticides and pesticide combinations on brain neurochemistry
Pesticides have been suggested to play a role in the development of many neurodegerative diseases including Parkinson's disease and Alzheimer's disease. Additionally, it has been suggested that exposure to pesticides and other environmental chemicals during the early stages of life could result in …
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The morphology, neurochemistry, and consequences of sympathosensory plexuses
The development, maintenance, and survival of neurons depend on the function of neurotrophins such as nerve growth factor (NGF). One population of neurons that rely heavily on NGF for axonal growth and survival is the postganglionic sympathetic neurons. Trauma or disease resulting in injury to the …
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Exploring single cell neurochemistry with multimodal MALDI MS
… at cellular resolutions. While measuring neurochemistry at cellular resolutions is important for understanding emergent properties, such as cognition and memory, analyzing the chemical nature of the brain at the single cell level is primarily limited to a handful of analytical approaches …
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An examination of the impact of dietary lipids on behaviour and neurochemistry
The molecular and cellular basis of stress pathology remains an important research question in biological science. A better understanding of this may enable the development of novel approaches for the treatment of stress-related disorders. There is a considerable body of scientific evidence …
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Manganese Toxicity: Accumulation in Bone, Effect on Brain Neurochemistry, and Impact on Adult Neurogenesis
… Toxicity: Accumulation in Bone, Effect on Neurochemistry, Impact on Adult Neurogenesis. Major Professor: Wei Zheng.
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The effects of prenatal and early-postnatal ethanol exposure on rat brain neurochemistry and behaviour
Foetal alcohol spectrum disorder (FASD), the umbrella term used to describe the wide range of cognitive and behavioural deficits observed after exposure to alcohol in utero, is a major public health issue specifically in South Africa. South Africa is thought to have the highest prevalence of FASD …
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Parsing Distinct Aspects of the Addiction Process Using Cocaine Self-Administration, Behavioral Economics, Neuropharmacology and Neurochemistry
In order to develop a better understanding of the neurobiological basis of cocaine addiction, scientists have begun to investigate the neural adaptations occurring in association with changes in behavior observed in animal models of addiction. Exactly how these behavioral changes relate to the …
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Formulation of electrophoretic module for integration onto silicon-on-insulator neural probes
… become a key analytical technique, especially in neurochemistry, due to its high separation efficiency and ability to analyze complex mixtures at a small scale [1]. However, challenges remain when it comes to scaling CE systems to match the demands of specific applications, particularly in …
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A systems approach to determine how Toxoplasma gondii Infection causes neuropsychiatric disease
… that adult acquired infection alters the neurochemistry and transcriptome of the brains of BALB/c mice. Notable changes to tryptophan, purine, arginine and carnitine metabolism were observed in infected mice.Congenitally infected and mice exposed to the maternal immune response to T. …
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Examining the Acute and Chronic Effects of Sepsis on the Circadian Clock in the Mouse
… and SCN responsiveness were assessed. SCN neurochemistry was also assessed both in the acute phase and in the long-term post LPS treatment. LPS induced sepsis did not affect core circadian locomotor rhythmicity parameters, but did result in long-term attenuations in post-septic resetting in …
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Capillary Electrophoretic Technologies for Single Cell Metabolomics
… when working with larger brain regions. Also, as neurochemistry can be different even in adjacent neurons, single cell measurements allow a unique perspective on cell-cell signaling in the brain. Here several instrument platforms have been created that combine capillary electrophoresis (CE) with …
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The Neural Underpinnings of Obsessive-Compulsive Disorder: From Adolescence to Adulthood
… robust negative correlations between neurochemistry and connectivity, while adolescents with OCD showed significantly weakened coupling. Across the full age range, developmental modelling using generalized additive models revealed that neurochemical alterations in OCD emerge …
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Longitudinal analysis of Brain Metabolite levels for HIV infected Children from ages five to eleven
… there is still some underlying effect on their neurochemistry which sets their development apart from the normal healthy profiles we expect.
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Analysis of D-Aspartate as a Signaling Molecule in the Aplysia Californica Central Nervous System Using Capillary Electrophoresis and Radioisotopic Labeling
… model system for studying the function and neurochemistry of D-Asp. Using Aplysia californica , we have investigated the localization of D-Asp as well as its synthesis from L-Asp. We developed a technique utilizing off-line CE coupled with radionuclide detection, which enables high …
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Simultaneous PET/fMRI for imaging neuroreceptor dynamics
… the opportunity to explore the underlying neurochemistry of brain function in more detail. Imaging these dynamics plays an important role for understanding drug action and function of neurochemical pathways in the brain and is crucial, yet largely unexplored, for creating and evaluating …
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The mGluR2/3 Agonist LY397268 Improves Morphometric and Behavioral Outcomes in R6/2 Huntington's Disease Mice
… projection neurons were normalized in their neurochemistry. The R6/2 data indicate that LY379268 is particularly useful in improving the health and functioning of the direct striatal pathway (i.e. SP+ neurons), which demonstrably improved the voluntary motor behavior in the R6/2 mice.</p>
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A CHAIR BASED YOGA WORKSHOP FOR SELF-CARE AND STRESS MANAGEMENT FOR SOCIAL WORKERS AND MENTAL HEALTH PROFESSIONALS
… practices can positively impact neurochemistry and brain biology. Most of the yoga positions and breathing exercises are practiced from a chair and can be adapted to any level of flexibility and fitness level. Designed to make yoga accessible for everyone, the techniques are …
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