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Showing 1 to 20 of 43 for “"neuroblasts"”.
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Myosin Dynamics in Drosophila Neuroblasts Lead to Asymmetric Cytokinesis
… one pole. Unlike most systems, Drosophila neuroblasts have a centrally localized metaphase plate but divide asymmetrically. Drosophila neuroblasts divide asymmetrically due to the presence of a polarized myosin domain at the basal pole during mitosis. I investigated the mechanism by which …
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Mechanisms of regulation of sloppy-paired genes in the temporal patterning program of optic lobe medulla neuroblasts in drosophila
Submission published under a 24 month embargo labeled 'U of I Access', the embargo will last until 2024-05-01
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An Interactive Natural Host Model System for a Swine Alphaherpesvirus: Aujeszky's Disease Virus Cell Interactions in Immortalized Porcine Olfactory Neuroblasts
Following the comprehensive characterization of the novel cell line, we infected the OBGF400 cells with ADY and investigated the ensuing comprehensive gene expression profile in comparison to a non-neuronal cell line, again by utilizing the Affymetrix array chip. The conducted studies exerted a …
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Mechanisms of Asymmetric Protein Localization in Drosophila Embryonic Neural Stem Cells
… of Prospero and Miranda. In embryonic and larval neuroblasts of lgl and dlg mutants, all basal targeted proteins become uniformly localized but distributions of the apical proteins are unaffected. In neuroblasts, Lgl protein is uniformly distributed at the cell cortex, and its cortical attachment …
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ANALYZING THE FUNCTIONS OF PREFOLDIN COMPLEX IN NEUROBLAST HOMEOSTASIS OF DROSOPHILA MELANOGASTER
… the severe asymmetric division defects of both neuroblasts and Intermediate Neural Progenitors (INPs). Co-depletion of Prefoldin and Pins also induces dedifferentiation of INPs back into neuroblasts, while depletion either Prefoldin or Pins alone is insufficient to do so. Furthermore, knocking …
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Patterning the Drosophila Embryonic Central Nervous System: Establishing Neuroblast-Specific Gene Expression and Identity
… array of neural precursor cells, called neuroblasts. Neuroblasts are unique, based on their position in the embryo, the genes they express, and the number and type of neuronal progeny they produce. A fundamental problem in the development of any animal is how to generate cell diversity. …
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Neuroblast lineage and cell fate specification in the Drosophila central nervous system
… invariant lineage of neural precursors called neuroblasts. It has been proposed that a class of genes are expressed in neuroblasts and their progeny and control the cell lineage of each neuroblast.
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Investigating the Morphology and Behaviour of Quiescent Neural Stem Cells in Drosophila Melanogaster
… melanogaster, neural stem cells, also known as neuroblasts, undergo a similar period of quiescence. Neuroblasts divide during embryogenesis to generate neurons and glia for the larval nervous system. Just before hatching neuroblasts enter quiescence and cease diving. They also adopt a specific …
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
… Numb, as well as mitotic spindle orientation in neuroblasts. The other player is Drosophila cytoplasmic dynein light chain 1, also named Cut up (Ctp). Ctp localizes at centrioles and controls the mitotic spindle orientation in neuroblasts. Ctp directly interacts with a centriolar protein Anastral …
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Pten Function in Postnatal Brain Development and Tumorigenesis
… and astrocytes.</p> <p> Neuronal precursors (neuroblasts) are generated every day throughout life in the subventricular zone (SVZ) and migrate through the rostral migratory stream (RMS) to the olfactory bulb where they differentiate into mature interneurons. The signaling pathways instructing …
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Molecular regulation of neuroblast migration in the postnatal brain
… Finally, selective<br/>deletion of RalA in RMS neuroblasts in vivo further confirms that RalA is required<br/>for correct polarised morphology of migrating neuroblasts in the RMS.<br/><br/>In summary, RalA is activated by CB agonists, and is required for CB-promoted<br/>migration of RMS …
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The Role of Transcription Factors in Regulating Adult Neurogenesis after Excitotoxic Brain Injury
… in transitamplifying- precursor cells (TAPs) and neuroblasts was examined following quinolinic acid (QA) lesioning of the adult rat striatum. It was demonstrated that TAPs responded to lesioning in a heterogeneous manner, with expansion particularly of the Dlx2+ subpopulation. Dlx2+ neuroblasts …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… the genetic mechanisms that control migrating neuroblasts.The model organism Caenorhabditis elegans provides a strong model to study migrating neuroblasts. C. elegans have a complete nervous system containing 302 neurons and an extensive genetic toolkit to work out genetic mechanisms involved. …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely in the cerebral cortex. However, the cellular mechanisms enabling these unique migratory routes through the compacted cellular landscape …
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Characterization of Novel Neuronal Antigens in the Central Nervous System of Manduca Sexta
… molecule. The presence of Ms-golgin80 in mitotic neuroblasts and ganglion mother cells and its reduced expression in their differentiated neuronal progeny suggests that this protein may be involved in maintaining the mitotic property of mitotic cells through active vesicle transport in the Golgi …
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Neurotransmitter patterning in the embryonic ventral nerve cord of Drosophila melanogaster
… specification in the developing fruit fly brain. Neuroblasts constitute the fundamental developmental units of the insect nervous system, each generating a unique lineage. Our understanding of neuroblast lineages at the anatomical level contrasts sharply with a lack of understanding of their …
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Molecular and cellular mechanisms of cortical functional regeneration through diterpenoid-induced neurogenesis
… (SVZ) responds to cortical injury by generating neuroblasts that attempt to migrate toward the damaged area. However, most fail to reach or integrate into the lesion unless stimulated by signals or chemical compounds like diterpene EOF2. This thesis investigates the cellular and molecular …
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Characterization of the pleiotropic effects of the Drosophila gene mushroom body miniature B
… development of mushroom body neuroectoderm and neuroblasts. Additionally, I found the observed delay in growth and reduced viability were not manifested during embryonic development; Courtship behavior assays and immunohistochemical techniques were used to investigate causes of mbmB female …
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Stem cell based therapy of malignant brain tumors
… immunoreactivity, and migration of striatal neuroblasts from the SVZ toward glioma. Although endogenous neuroblast migration toward gliomas was of moderate magnitude, this indicates a region specific reparative mechanism in response to tumor growth. We continued by implanting rat SVZ-derived …
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Cell replacement strategies in the central nervous system in two mouse models of neuronal damage: potential therapeutic targets and promising drugs
… found around the injury. Despite the attempt of neuroblasts to migrate toward the injury, they fail to cross the corpus callosum and reach the perilesional area. We have aimed in this thesis to understand the mechanisms impairing migration. Our results indicate that in response to an injury, …
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