Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 35 for “"neuroblast"”.
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Molecular regulation of neuroblast migration in the postnatal brain
… Finally, selective<br/>deletion of RalA in RMS neuroblasts in vivo further confirms that RalA is required<br/>for correct polarised morphology of migrating neuroblasts in the RMS.<br/><br/>In summary, RalA is activated by CB agonists, and is required for CB-promoted<br/>migration of RMS …
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MiRNA influences in mesenchymal stem cell commitment to neuroblast lineage development
… and if they can induce MSCs to commit to a neuroblast and/or mature neuron cell lineage. The selected miRNAs were miR-107, miR-124 and miR-381, which respectively are known to promote neurogenesis, neural differentiation and neural proliferation. Targeting protein expression by transiently …
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ANALYZING THE FUNCTIONS OF PREFOLDIN COMPLEX IN NEUROBLAST HOMEOSTASIS OF DROSOPHILA MELANOGASTER
… Prefoldin depletion results in disruption of neuroblast polarity, leading to neuroblast overgrowth in Drosophila larval brains. Co-depletion of Prefoldin and Partner of Inscuteable (Pins) leads to the formation of gigantic brains with dramatic neuroblast overgrowth, due to the severe …
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New Insights into the Regulatory Network Controlling Neuroblast Migration in C. elegans
… the genetic mechanisms that control migrating neuroblasts.The model organism Caenorhabditis elegans provides a strong model to study migrating neuroblasts. C. elegans have a complete nervous system containing 302 neurons and an extensive genetic toolkit to work out genetic mechanisms involved. …
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Neuroblast lineage and cell fate specification in the Drosophila central nervous system
… invariant lineage of neural precursors called neuroblasts. It has been proposed that a class of genes are expressed in neuroblasts and their progeny and control the cell lineage of each neuroblast.
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The Role of EphA Receptor Signaling in Neuroblast Survival During In Vitro Differentiation
… rosettes, where it co-expresses with markers of neuroblast identity. However, the role of Eph receptors and ephrins in neurogenesis is not well understood.</p> <p>Previous literature had shown that ephrin-A5 and EphA7 can function to balance cortical apoptosis during embryogenesis. We …
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Patterning the Drosophila Embryonic Central Nervous System: Establishing Neuroblast-Specific Gene Expression and Identity
… array of neural precursor cells, called neuroblasts. Neuroblasts are unique, based on their position in the embryo, the genes they express, and the number and type of neuronal progeny they produce. A fundamental problem in the development of any animal is how to generate cell diversity. …
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ANALYSIS OF TWO NOVEL COMPLEXES THAT REGULATE NEUROBLAST SELF-RENEWAL AND ASYMMETRIC DIVISION IN DROSOPHILA MELANOGASTER
Drosophila neuroblast divides asymmetrically to produce a self-renewing neuroblast and a ganglion mother cell that is committed to differentiation. The balance between neuroblast self-renewal and differentiation is tightly controlled to ensure the proper development of the central nervous system. …
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Investigating the roles of candidate gap genes from the neuroblast timer series during axial patterning in the beetle Tribolium
… this work, I investigate the hypothesis that the neuroblast timer genes nubbin (nub) and castor (cas) may act as components of the gap gene network in Tribolium. I first utilise Hybridisation Chain Reaction in situ hybridisation to produce a comprehensive description of the dynamics of gap gene …
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Investigating the Morphology and Behaviour of Quiescent Neural Stem Cells in Drosophila Melanogaster
… melanogaster, neural stem cells, also known as neuroblasts, undergo a similar period of quiescence. Neuroblasts divide during embryogenesis to generate neurons and glia for the larval nervous system. Just before hatching neuroblasts enter quiescence and cease diving. They also adopt a specific …
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The Role of Stromal-Derived Factors in Neuroblastoma Differentiation
<p>Neuroblastoma is a pediatric cancer arising from undifferentiated neural crest-derived precursor cells. Treatment strategies for neuroblastoma aim to promote neuroblast differentiation, however current therapies available are only modestly effective. The tumor stroma contributes to the …
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Analysis of Β8 Integrin In Neurogenesis and Neurovascular Homeostasis
… cells, which further differentiate to generate neuroblasts, which then migrate from the SVZ to the olfactory bulbs (OB) along the rostral migratory stream (RMS). ECM-mediated adhesion and signaling within the vascular niche likely contribute to proper NSC self-renewal, survival, differentiation …
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The role of Dichaete in transcriptional regulation during Drosophila embryonic development
… in this analysis have known roles during neuroblast development, including Hunchback and Krüppel, transcription factors involved in temporal specification of neuroblast division, and Prospero, which plays a key role in neuroblast differentiation. The analysis suggests that Dichaete has a …
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Transcriptional profiling of Drosophila larval ventral nervous system hemilineages
… of Drosophila are born from neuronal stem cells (neuroblasts) during the post-embryonic phase of neurogenesis. Most of the post-embryonic neurons derive from type I neuroblasts, which undergo repeated asymmetric divisions to produce a series of ganglion mother cells (GMCs). Each GMC then divides …
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Endogenous control of stochastic gene expression in the development of Caenorhabditis elegans
… the Wnt signaling pathway in a single C. elegans neuroblast. Analogous to vertebrate neural crest cells, Hox gene expression determines the migratory direction and the subsequent fate choices of cells that descend from the original neuroblast. Intrigued by the earlier observation that perturbation …
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The Role of the Proneural Transcription Factor ASCL1 in Neuroblastoma Cell Division and Differentiation
Neuroblastoma is the most common solid childhood cancer and typically has a very poor prognosis. Neuroblastoma is a ‘cancer of improper development’ and is thought to arise from sympathetic neuroblast precursors that fail to engage the neuronal differentiation programme; instead they are locked in …
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Neurotransmitter patterning in the embryonic ventral nerve cord of Drosophila melanogaster
… specification in the developing fruit fly brain. Neuroblasts constitute the fundamental developmental units of the insect nervous system, each generating a unique lineage. Our understanding of neuroblast lineages at the anatomical level contrasts sharply with a lack of understanding of their …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
… NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely in the cerebral cortex. However, the cellular mechanisms enabling these unique migratory routes through the compacted cellular landscape …
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Stem cell based therapy of malignant brain tumors
… of SVZ proliferating cells, increased SVZ neuroblast immunoreactivity, and migration of striatal neuroblasts from the SVZ toward glioma. Although endogenous neuroblast migration toward gliomas was of moderate magnitude, this indicates a region specific reparative mechanism in response to …
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Cell replacement strategies in the central nervous system in two mouse models of neuronal damage: potential therapeutic targets and promising drugs
… found around the injury. Despite the attempt of neuroblasts to migrate toward the injury, they fail to cross the corpus callosum and reach the perilesional area. We have aimed in this thesis to understand the mechanisms impairing migration. Our results indicate that in response to an injury, …
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