Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 10 of 10 for “"neuroAIDS"”.
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The effect of HIV-1 Tat and methamphetamine on expression of cytokines/chemokines and synaptic genes: Implications in HIV neuroAIDS
… provides potential therapeutic target for neuroAIDS.
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Profiling the neurovascular cell interactions in alcohol exposure and HIV-1 infection
… syndrome or HIV/AIDS in the brain, known as the NeuroAIDS. The mechanisms of this accelerated progression are still poorly understood. The purpose of my thesis is to review the parameters contributing to the co-morbid effects of alcohol in the progression of NeuroAIDS. The first aim will evaluate …
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DEVELOPMENT OF ANTAGONISTS TARGETING CHEMOKINE RECEPTOR CCR5 AND THE CHEMOKINE RECEPTOR CCR5 – MU OPIOID RECEPTOR HETERODIMER
… CCR5-MOR heterodimer and its relation with NeuroAIDS. The structural-activity relationship between the bivalent ligand and the heterodimer was studied with radio-ligand binding assays, functional assays, HIV-1 fusion assays, cell fusion assays, and in silico molecular dynamics. The …
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Persistent “hijacking” of brain proteasomes in HIV-associated dementia
… were performed using the resources of the Texas NeuroAIDS Research Center and the National NeuroAIDS Tissue Consortium, including clinical data and frontal cortex brain tissue from 153 autopsy cases. Assessment of frontal cortex proteasome proteolytic activity revealed an abnormal catalytic …
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Role of cytochrome P450 enzymes on alcohol/nicotine-mediated oxidative stress and cytotoxicity in monocytes/astrocytes: Implications for HIV-infected alcohol/tobacco users
… types in studying HIV-1 pathogenesis and AIDS/neuroAIDS development. Our results showed that 1) CYP2A6, CYP2E1 and CYP3A4 are induced by alcohol in U937 monocytes/macrophages, while only CYP2E1 is induced by alcohol at both mRNA and protein levels in SVGA astrocytes, 2) CYP2A6 metabolizes …
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Pathology and mechanisms of increased M.tb growth and dissemination during co-infection with HIV-1
… of our humanized mouse model for the study of neuroAIDS and the impact of M.tb on HIV in the brain. This work provides an important framework for future translational studies into co-infection pathology and mechanisms.
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Anomalies of GABAergic system associated with HIV-1 infection
… brains using the resources of the National NeuroAIDS Tissue Consortium, including clinical data and brain tissue from 515 аutоpsy cases. Lowered GABAergic transcripts were linked to the higher expression of immune and endothelial cell type markers and were associated with the decrease of …
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The Effect of Drugs of Abuse and HIV-1 GP120 on Autophagy in Astrocytes
… provides potential therapeutic target for neuroAIDS.
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Strategies for Neuroprotection Using Passive (Neurotrophin-Deprivation) and Active (Virotoxin Exposure) Models of Neuronal Cell Death
Thesis (Ph.D.)--University of Rochester. School of Medicine & Dentistry. Dept. of Microbiology and Immunology, 2004.
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Neuroinflammation and comorbid depression: a role for interleukin-1 beta converting enzyme and indoleamine 2,3-dioxygenase
… observed during disease progression, known as neuroAIDS. Neuroinflammation represents a significant component to many HIV-associated neurological disorders. Further, increased prevalence of comorbid depression is observed with HIV infection. HIV proteins have drawn significant interest for …