Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
Results
Showing 1 to 9 of 9 for “"neuraxis"”.
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Molecular-Genetic and Behavioral Analysis of the Functionality of Patterning in the Trigeminal Neuraxis
… lacking patterning in two areas of the vibrissal neuraxis to examine the functional role of patterning. We examined feeding behavior using a knockout of Prxxl, which abolishes somatotopic barrellette patterning in the lemniscal brainstem nucleus. Null animals were significantly smaller than …
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Modelling of the Human Corticospinal Motor Axis and Its Injury Using Organoids
… <i>in vitro</i> model of the human corticospinal neuraxis could serve as a system to investigate both human specific response to injury and further assess previously identified therapeutics from animal studies. In this work, development of such a system is shown, utilising stem cell derived …
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Encoding of periodic skin stimuli by spinal dorsal horn neurons
… has been investigated at many levels of the neuraxis. These studies, however, have not extended to the spinal dorsal horn, which is known to process low threshold mechanoreceptive input. The studies presented here were designed to assess the possible role of the dorsal horn in the encoding of …
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The role of serotonergic afferents in receptive field organization and response properties of cells in rat trigeminal subnucleus interpolaris
… field properties throughout the somatosensory neuraxis following damage to peripheral nerves. Chronic changes in receptive fields and response properties have also been reported in the trigeminal brainstem nuclear complex (TBNC) following trigeminal nerve damage in both neonates and adults. …
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Regulation of morphogen signalling during neural patterning in the Xenopus embryo
… RA gradients along the anteroposterior neuraxis.
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Allosteric Modulation of Metabotropic Glutamate Receptor 5 as a Treatment for Pain
… is expressed at synapses throughout the pain neuraxis where it is believed to modulate the function of ion channels that underlie nociceptive transduction and transmission. Injections of mGlu5 agonists cause hypersensitivity or nocifensive behavior when administered peripherally, …
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Olfactory ensheathing cell mediated mechanisms of neurite outgrowth and axon regeneration
The capacity of the olfactory neuraxis to undergo neuronal replacement and axon targeting following injury, has led to scrutiny concerning the molecular and physical determinants of this growth capacity. This is because injury to the central nervous system, in contrast, leads to permanent …
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Analysis of HOXA5 expression and function in development of the central nervous system
… structures, as well as in the embryonic neuraxis.</p>
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The spread of pathological assemblies in neurodegenerative disease
… misfolded α-synuclein appearing throughout the neuraxis. These deposits developed in neuroanatomically related regions in a pattern resembling prion neuroinvasion, suggesting that misfolded α-synuclein may propagate along neural pathways. We also show that neuropathology and neurodegenerative …