Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 70 for “"neural tissue"”.
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Diffusion and Magnetization Transfer Studies of Neural Tissue
… transfer do not offer a unique window to neural function, as had been suggested by some reports in the literature. Rather, our studies taken together with the literature suggest that both these phenomena affect the standard hemodynamics-dependent functional MRI signal. The work presented …
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Automation of single-cell techniques in neural tissue
… nature of cells in the context of native tissue environments necessitates the development of tools and techniques that can manipulate and analyze samples with single-cell resolution. While the past decades have seen significant progress in analyzing individual cells in tissue, both …
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Experimental evaluation of near infrared light penetration into neural tissue
… treatment purposes. Penetration depth into the tissue is a critical parameter to be considered in these NIR laser applications. Published data on the optical properties of rodent neural tissue are rare, despite the frequent use of rats as animal models. The aim of this study was to directly …
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Finite element modeling of temperature elevation due to NIR exposure in neural tissue
… is one of the most important concerns in the neural tissue when illuminated with NIR light. Rodent models are frequently used to study laser-tissue interactions. As a part of ongoing research project in the neural interface laboratory, direct measurements of temperature in the rat brain cortex …
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In vitro feasibility testing of floating light-activated minroelectrical stimulators
One of the major challenges of neural stimulation is the mechanical stress and resulting trauma induced on the implanted electrodes by the constant movement of the interconnects. A potential way of eliminating interconnects is to use floating micro-stimulators that can be activated through optical …
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Diplostomulum trituri (Trematoda: diplostomatidae) a larval strigeoid trematode in the brain and cranial case of the newt, Notophthalmus viridescens (Rafinesque)
… increased size of the ventricles and loss of neural tissue. Neurophysiological symptoms of parasitism include sluggish behavior and poor reflexes. Black material was observed in the lumen of the intestinal ceca. Several mesocercariae were observed to be attached to the neural tissue by their …
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Modelling Cell Orientation In Artificial Tissues
Engineered tissues have many potential applications both as experimental systems and in therapeutic devices and treatments. Specially, there is potential to repair damaged spinal cord, however work is still needed to predict the process of tissue growth. Computational physics has potential to …
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Temperature elevations due to NIR exposure in the brain tissue
… Temperature elevation profile inside the tissue is a critical factor that needs to be better understood in these applications. The purpose of this study is to determine the temperature distribution due to a low power N I R laser irradiation in living neural tissue. Temperature measurements …
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Sensing in 3D Printed Neural Microphysiological Systems
… overall goal of producing sensor functionalized neural microphysiological systems to enable deeper fundamental understandings of disease pathology and to provide drug screening and discovery platforms for improved clinical translation. Towards this goal, work addressing three broad objectives has …
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Design and fabrication of a microneedle for the implantation of floating microstimulators
Neural prosthetics are used to stimulate any remaining functional nervous tissue in order to restore function in visual, auditory, or other physiological components associated with the nervous system. Microelectrodes have been used in stimulating and detecting electrical activity in neurons. When …
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Monoallelic Gene Expression In Human Neural Stem Cells
… cells (Gimelbrant et al. 2007) and mouse neural stem cells (Wang et al.2010; Li et al. 2012). However, the extent to which RME occurs in human neural tissue is unknown. Using a genome-wide analysis of allele-specific expression in human neural stem cells, I reveal that 1.6 to 2.2% of …
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Supramolecular architectures for neural prostheses
Neural prosthetic devices offer a means of restoring function that have been lost due to neural damage. The first part of this thesis investigates the design of a 15-channel, low-power, fully implantable stimulator chip. The chip is powered wirelessly and receives wireless commands. The chip …
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Modelling neuroimmune interactions using organotypic slice cultures
… of a Mycobacterium tuberculosis infection of neural tissue, researchers have hitherto relied on two animal models namely, in vivo intracranial infections or in vitro culturing with dissociated neural cells. Both models have yielded crucial insights concerning CNS-TB but each have limitations …
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Characterizing neural tissues with mass spectrometry imaging via enhanced computational approaches
… their chemical and spatial heterogeneity within neural tissue, but most imaging techniques do not provide the complete information desired. To provide chemical information, most imaging techniques used to study the nervous system require preselection and labeling of the peptides of interest; …
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The HLA Complex Group 9 Gene Modification Study in Major Psychosis
… between BPD samples and controls across all tissues and demonstrated the utility of WBC DNA modification density as an epigenetic marker for BPD. We further extended our analysis to full length HCG9 with bisulfite padlock probe-based deep sequencing in SCZ, BPD and control post-mortem brain …
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Modulation of Axonal Transmission by Metabolic Stress
Electrical signaling by neural tissue is responsible for ~20% of the basal metabolic rate. This high-energy consumption predisposes neural tissue to metabolic stress that can compromise signaling and cause irreversible damage. The locust central nervous system (CNS), however, has adaptive …
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Electrochemical neuromodulation using electrodes modified with ion-selective materials, based on the physical process of ion-concentration polarization
… of selected ions in the interstitial space of neural tissue. Its principle of operation is based on ion-concentration polarization (ICP) generated by polarization of electrodes covered with ion-selective membranes (ISMs). In order to optimize this modality in terms of clinical effect and …
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3-D optical waveguide arrays for in-vivo optogenetics : development and application
A key feature of neural circuits in the mammalian brain is their 3-dimensional geometric complexity. The ability to optically drive or silence sets of neurons distributed throughout complexly shaped brain circuits, in a temporally precise fashion, would enable analysis of how sets of neurons in …
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Eph-mediated restriction of cerebrovascular arteriogenesis
… attempting to restore blood flow to vulnerable neural tissue regions. Enhancement of pial collateral remodeling (Arteriogenesis) has recently been shown to improve blood flow and mitigate neural tissue damage following stroke (1-3). Arteriogenesis is the remodeling of pre-existing arteriole …
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DEEP LEARNING ALGORITHMS FOR OPTICAL COHERENCE TOMOGRAPHY IMAGES WITH APPLICATIONS IN GLAUCOMA
… 3D biomechanical changes of the optic nerve head tissues (ONH), is indeed a well-known risk factor and considered as the only clinically treatable one. Since the inception of optical coherence tomography (OCT) technology, it has been possible for the in vivo assessment of these morphological …
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