Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 75 for “"neural stem cell"”.
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Isolation, Culture and Cryopreservaion of Neural Stem Cell
… intermediated filament proteins and a well-known stem cell marker in the neural lineage. The nestin gene consists of four exons and three introns. It has been known that the nestin transgene containing the second intron is sufficient to direct tissue specific expression of the nestin gene in …
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Identifying regulators of neural stem cell fate and tumourigenesis
The proliferation of neural stem cells (NSCs) must be regulated precisely in order to generate a functional nervous system. Mis-regulated NSC division can lead to the inadequate production of differentiated progeny or to ectopic NSCs and tumour formation. As such, genes that promote the …
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Systemic and local signalling regulating neural stem cell proliferation
Neural stem cells (NSCs) in the brain can be reactivated to exit quiescence and generate new cells in response to injury or disease. Determining the specific signals involved in NSC reactivation is essential to understanding neural regeneration. Investigating NSCs in *Drosophila melanogaster* …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
Neural stem/progenitor cells (NSPCs) play a crucial part in the evolutionary development of the human neocortex. During early postnatal development, NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely …
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Nutritional regulation of neural stem cell reactivation in Drosophila melanogaster
… nutritional intake. The transition between neural stem cell (NSC) quiescence and reactivation is a key point of regulation during neurogenesis, and in Drosophila, this process is tightly coupled to nutrient availability. Post-embryonic NSCs in Drosophila only exit quiescence when larvae are …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
Majority of adult mammalian neural stem cells are quiescent, remaining in an actively maintained state of cell cycle arrest. Quiescent and actively proliferating neural stem cells can be distinguished by their transcriptional state, however, the understanding of how these gene signatures are …
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Neural stem cell expansion rejuvenates learning strategies and memory throughout life
Der Hippocampus ist ein Hirnareal welches fundamental für die Generierung von bewussten Erinnerungen und für die Etablierung von flexiblen Beziehungen zwischen kontextuellen Repräsentationen ist. Hippocampale Fehlfunktion während des Alterns wurde als ein Schlüsselfaktor für den kognitiven …
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Neural stem cell differentiation in collagen scaffolds for retinal tissue engineering
Rat neural stem cells (NSCs) were cultured in monolayer or in porous collagen scaffolds and exposed to neurogenic or non-neurogenic medium to determine the effects on neural differentiation and neurite growth. Nestin, [beta]III-tubulin, and GFAP expression were determined using immunofluorescent …
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Understanding the role of dMob4 in postembryonic Neural Stem Cell mitotic reactivation
Brain homeostasis supports cognition and neural plasticity, the brains’ ability to adapt to its environment throughout life. These processes rely on replenishment from stem cells in the brain, termed Neural Stem Cells (NSCs). In the adult brain, most NSCs exist in a quiescent state and must …
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Jagged1 regulates adult neural stem cell maintenance and multipotency through activation of Notch1
… die Entwicklung und Differenzierung der adulten neuralen Stammzellen steuern, sind noch <br>grösstenteils unbekannt. Dem Ziel, die grundlegenden Mechanismen der Neurogenese im adulten Gehirn zu Verstehen, kommt angesichts der möglichen Behandlungen von neurologischen Krankheiten wie auch …
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DIFFERENTIATION OF NEURAL STEM CELL USING SMALL MOLECULES IN 2D AND 3D CULTURE SYSTEM
The neuronal differentiation of neural stem cells (NSCs) has received much attention due to its potential for the treatment of neurodegenerative diseases (i.e., Parkinson’s and Alzheimer’s diseases). In this regard, discovering compounds that direct differentiation of NSCs is highly required to …
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Cellular and Circuit Level Responses to Neural Stem Cell Transplantation in the Rodent Cortex
Neural stem cell (NSC) transplantation is a promising strategy for the treatment of neurological disease and injury. NSC transplants have been documented to exert both neurotrophic and immunomodulatory effects in pathological contexts, but grafted cells frequently remain undifferentiated. The …
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Towards an understanding of the role of Ca2+ signalling in neural stem cell activation
… challenge. The adult mammalian brain contains neural stem cells (NSCs) that are capable of brain repair, but they are mostly in a mitotically quiescent state. Identifying novel regulators of neural stem cell quiescence will provide more molecular targets for brain regeneration therapies. …
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Metabolic control of neural stem cell function in a patient-derived model of multiple sclerosis
… disorder affecting the central nervous system (CNS), results in the deterioration of myelin sheaths and neuronal injury. For reasons that remain unclear, the majority of patients eventually enter a disease stage termed progressive MS (PMS), which is characterised by a substantial failure …
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Using single cell transcriptomics to uncover mechanisms of neural development, neural stem cell quiescence and tumourigenesis
Neural stem cells produce all the cells of the nervous system and regulation of proliferative behaviour is crucial for proper brain development. Over-proliferation of NSCs can also lead to disease, resulting in the formation of tumours. There is a delicate balance between NSC proliferation, …
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Neural stem cell grafts and the influence of apolipoprotein E in a mouse model of global ischaemia
Neural stem cell (NSC) transplantation is a promising therapy for the treatment of brain damage. Although the “proof of principle” for NSC transplantation therapy has been demonstrated in a variety of animal models of brain injury (stroke, traumatic brain injury, ageing) and in a clinical setting …
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Human Neural Stem Cell-Derived Neuron/Astrocyte Co-Cultures as a Model System to Study Emerging Encephalitic Viruses
… viral infections target the central nervous system. Such diseases often cause high fatality rates and high rates of neurologic sequelae such as behavioral changes, cognitive deficits, seizures, paralysis, or persistent infection. Relatively little is known about viral infections of cells within …
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Exploring Dystrophin-Mediated Control of Neural Stem Cell Fate Associated with Intellectual Disability In Duchenne Muscular Dystrophy Patients
… I investigated the hippocampal and amygdala cellular and behavioural phenotypes of the mdx mouse. I show that post-natal neural stem-like cell division in the SGZ is altered in the absence of Dp427 resulting in enhanced symmetric division. I show in vitro that primary mdx cultures are fewer …
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Applications for human neural stem cell-derived motor neurons in amyotrophic lateral sclerosis: Cell replacement therapy and disease modeling
… ALS is to explore the potential of human fetal neural stem cells (hNSCs) to replace lost motor neurons. The therapeutic efficacy of stem cell transplantation would depend greatly on the survival of grafted stem cell-derived motor neurons in the microenvironment of the spinal cord in ALS. …
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Molecular mechanisms of neural stem cell plasticity and neuro-regeneration in an Alzheimer’s-like neurodegeneration model of adult zebrafish
… reduced proliferative and neurogenic ability of neural stem cells (NSCs), which normally produce neurons, albeit rather a limited lineage. Recently, in AD patients, neurogenic outcome was shown to reduce dramatically (Moreno-Jimenez et al., 2019; Tobin et al., 2019). This lack of neurogenic input …
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