Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 20 of 185 for “"neural stem"”.
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Neural Stem Cells in Brain Tumor Development
… mouse models indicated a central role for neural stem cells and stem cell-like cancer cells in malignant astrocytoma formation. Using stereotactic viral cre-mediated approach, we demonstrate that targeting of tumor suppressor inactivating mutations in the subventricular zone (SVZ) where …
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Transdifferentiation of fibroblasts to neural stem cells
… indistinguishable from an embryonic stem (ES) cell. However, it is still unclear if transcription factors can completely convert the nucleus of a differentiated cell into that of a distantly related somatic cell type with complete transcriptional and epigenetic reprogramming …
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Primitive Neural Stem Cells in the Mouse Brain
Neural stem cells (NSCs) reside in the tissue lining the lateral ventricles of the adult mouse brain. At the top of the hierarchy are primitive (p)NSCs that arise in advance of definitive (d)NSCs embryonically. After the discovery that pNSCs persist in the adult mouse brain, I sought out to …
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The Tumor-Suppressive Properties of Neural Stem Cells
… (GBM) is an aggressive central nervous system malignancy that commonly causes immune suppression in patients to avoid immune recognition and clearance. This complicates treatment options and limits the effectiveness of immunotherapy strategies. Interestingly, GBM formation can stimulate …
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Monoallelic Gene Expression In Human Neural Stem Cells
… cells (Gimelbrant et al. 2007) and mouse neural stem cells (Wang et al.2010; Li et al. 2012). However, the extent to which RME occurs in human neural tissue is unknown. Using a genome-wide analysis of allele-specific expression in human neural stem cells, I reveal that 1.6 to 2.2% of …
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Adult Neural Stem Cells and Their Perivascular Niche
Stem cells reside in specialized niches that support their selfrenewal and differentiation. A balance between intrinsic and extrinsic signals mediates stem cell quiescence, activation and proliferation. In the mammalian subventricular zone (SVZ), the stem cells are a subset of GFAP+ astrocytes. A …
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Isolation, Culture and Cryopreservaion of Neural Stem Cell
… intermediated filament proteins and a well-known stem cell marker in the neural lineage. The nestin gene consists of four exons and three introns. It has been known that the nestin transgene containing the second intron is sufficient to direct tissue specific expression of the nestin gene in …
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Glioma produced periostin attracts human neural stem cells
"Stem cells from various lineages have been well known for their migration tendency toward glioma and become attractive vehicles to deliver therapeutic genes to brain tumors. However, which factors and mechanisms in these processes are not yet known. In the present study, I aimed at identifying the …
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Neural Stem / Progenitor Cells in the Adult Mouse Hypothalamus
Adult neural stem cells are now widely accepted to exist in the neurogenic regions of the subventricular zone and dentate gyrus; however there is increasing evidence to suggest that neurogenesis may also occur in other brain regions. It has been proposed that one such population of neural stem …
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Neurogenesis from Neural Stem Cells, Ependymal Cells and Fibroblasts
… different sources such as fetal brain, embryonic stem cells and induced pluripotent stem cells are associated with ethical issues and carry the risk of immune rejection and tumorigenicity. Direct conversion of patient’s own skin cells to neurons could overcome these problems and potentially …
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Diacylglycerol lipaseα-dependent endocannabinoid signaling in neural stem cells
… this thesis is on DAGL driven eCB signaling in neural stem cells (NSC). A role of the eCB system has previously been established in migration, proliferation, and neurogenesis. Here we investigated DAGLα and eCB signaling in the context of differentiation. <br/>The Cor-1 cells were adapted as a …
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Characteristic analysis of mobility inducers for neural stem cells
Recently neural stem cells (NSCs) were reported to migrate to damaged brain areas, such as brain tumors or ischemic regions. Systemic strategy can be effective to cancer therapeutic effect through cell-based gene therapy. From our previous studies, we identified chemoattractant molecules-1(CM-1) …
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Characterization of Neural Stem Cells Using the Nestin Enhancer
… filament, is known as a specific marker for neural stem cells and regulated by the enhancer located on the second intron of the gene. The second intron is highly conserved among species and crucial for the nestin expression in central nerve system (CNS) progenitor cells. The transgenic mice …
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Identifying regulators of neural stem cell fate and tumourigenesis
The proliferation of neural stem cells (NSCs) must be regulated precisely in order to generate a functional nervous system. Mis-regulated NSC division can lead to the inadequate production of differentiated progeny or to ectopic NSCs and tumour formation. As such, genes that promote the …
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Systemic and local signalling regulating neural stem cell proliferation
Neural stem cells (NSCs) in the brain can be reactivated to exit quiescence and generate new cells in response to injury or disease. Determining the specific signals involved in NSC reactivation is essential to understanding neural regeneration. Investigating NSCs in *Drosophila melanogaster* …
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Modeling Neural Stem Cell Dynamics in Congenital Heart Disease
Neural stem/progenitor cells (NSPCs) play a crucial part in the evolutionary development of the human neocortex. During early postnatal development, NSPCs give rise to immature neurons called neuroblasts within the subventricular zone (SVZ) that utilize unique migratory streams to integrate widely …
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Neural Stem Cells as a Model to Study Huntington’s Disease
… affects the cytoskeletal structures using neural stem cells Q7 (wild type) and Q140 (mHtt) and differentiated neurons as a model for studying HD. In addition we looked at the interference of mHtt protein with RRAS, the downstream signaling components of Plexin/Semaphorin pathway of the …
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Suicide Gene therapy for Malignant Gilomas using Neural Stem Cells
… of treatment for the malignant gliomas with neural stem cell (HB1.F3) transduced with suicidal gene using the tropism of stem cells. MATERIALS AND METHODS: E.coli cytosine deaminase(CD) of suicide gene is enzyme that catalyzes the conversion of noncytotoxic 5-FC to the cytotoxic and …
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Nutritional regulation of neural stem cell reactivation in Drosophila melanogaster
… nutritional intake. The transition between neural stem cell (NSC) quiescence and reactivation is a key point of regulation during neurogenesis, and in Drosophila, this process is tightly coupled to nutrient availability. Post-embryonic NSCs in Drosophila only exit quiescence when larvae are …
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Modelling chromatin dynamics in neural stem cell quiescence and reactivation
Majority of adult mammalian neural stem cells are quiescent, remaining in an actively maintained state of cell cycle arrest. Quiescent and actively proliferating neural stem cells can be distinguished by their transcriptional state, however, the understanding of how these gene signatures are …
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