Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 17 of 17 for “"neural regeneration"”.
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Microfluidic in vivo laser microsurgery screen for identification of compounds enhancing neural regeneration
… and novel mechanisms for enhancing neurite regeneration in animal models is significant for therapeutics of central nervous system injuries and neurodegenerative disorders. C. elegans is a widely studied model organisms due to their fully mapped neural network of 302 neurons and amenable …
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Spectral Sensitivity of the Goldfish ERG and Optic Tectum Before and After Optic Nerve Damage
… visual system has served as a useful model for neural regeneration studies. However, most of the research on neural regeneration has focused on the recovery of anatomical connections; little has been done assessing the return of visual function. The purpose of this study was to determine the …
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Methods and technologies for high-throughput and high-content small animal screening
… a small-molecule library for factors affecting neural regeneration following femtosecond laser microsurgery of C. elegans using these technologies. This screen identifies the kinase inhibitor staurosporine as a strong inhibitor of neural regeneration, and does so in a concentration and neuronal …
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Discovery of the novel mouFSnrp gene and the characterisation of its in situ expression profile during mouse neurogenesis
Recently, a novel protein family, named as neural regeneration peptides (NRPs), was predicted across the rat, human and mouse genomes by one of my supervisors, Dr. Sieg. Synthetic forms of these proteins have been previously shown to act as potent neuronal chemoattractants and have a major role in …
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Enhancing mRNA stability through the addition of stabilizing untranslated regions
… applications ranging from tissue engineering to neural regeneration. This transient nature of mRNA, however, limits the duration of gene upregulation, and potentially reduces the efficacy of mRNA therapy. In this paper, various mRNA constructs were studied to identify stable designs which could …
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Bioengineering Microporous Annealed Particle Scaffolds to Recruit Neural Progenitor Stem Cells and Promote Angiogenesis in the Stroke Core
… highly attractive. However, this process of neural regeneration is complex and requires a series of controlled biological events, such as recruitment and differentiation of neuron progenitor cells (NPC’s), angiogenesis, and axonogenesis. Biomaterials are now commonly used to research tissue …
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Phase separation in thermally-drawn fibers: From porous domains to structured Si-Ge spheres
… and characterization of scaffolds for neural regeneration. In addition, we show that the same principle can also be used to draw a functional lithium-ion fiber battery; a fiber device capable of electrochemical energy storage. Finally, we demonstrate how to produce structured Si-Ge …
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Application of self-rolled-up membrane technology for enhanced neuron guidance and alignment
Neural circuits are fundamental components that regulate critical autonomic functions throughout the human body. Disruption of neural circuits, through neurodegenerative diseases such as Parkinson’s disease or multiple sclerosis, as well as sensory neuropathies, and traumatic injuries can be …
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Systemic and local signalling regulating neural stem cell proliferation
Neural stem cells (NSCs) in the brain can be reactivated to exit quiescence and generate new cells in response to injury or disease. Determining the specific signals involved in NSC reactivation is essential to understanding neural regeneration. Investigating NSCs in *Drosophila melanogaster* …
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Investigation of electrospun fibrous scaffolds, locally delivered anti-inflammatory drugs, and neural stem cells for promoting nerve regeneration
… the selection of a suitable scaffold to aid in regeneration. The scaffold must have sufficient mechanical strength while providing an intricate network of passageways for axons, Schwann cells, oligodendrocytes, and other neuroglia to populate. If neural regeneration is to occur, these intricate …
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Elucidating the role of bone morphogenetic protein-4 in regulating secondary injury mechanisms following traumatic spinal cord injury
… contribute to tissue degeneration and limit neural regeneration and repair after injury. To optimize future therapeutic approaches, it is necessary to identify factors that regulate the early stages of these endogenous responses in order to limit their deleterious effects. In a pre-clinical …
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Regeneration of Peripheral Nerves Using Neuroinductive Biomaterial Scaffolds
… Biomaterial scaffolds are promising for use in neural reconstruction, but to date, no neuroinductive biomaterials capable of acting directly on regenerative cells to stimulate nerve growth have been identified. The goal of this dissertation work was to develop and investigate the effectiveness …
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Function and evolution of the atypical Notch ligands Dlk1 and Dlk2 during vertebrate development
… that, in the absence of DLK2, a population of neural precursor cells appear to over-proliferate early in zebrafish development. Later, by larval stages, these cells are absent, suggesting a premature activation and subsequent depletion of the progenitor cell pool in the mutant, reminiscent of …
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Analysis of Zebrafish Optic Tectum Visual Processing Before and After Optic Nerve Crush
… The second purpose of this study was to examine neural regeneration in the adult zebrafish at various times post-crush and to compare visual processing of these subjects to the normal subjects. The optic nerve tracts of the zebraflsh's right eye were damaged via optic nerve crush and subjects …
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Topological organization of the trigeminal system in the lamprey and restoration following axonal regeneration
… vertebrates, the lamprey displays robust axonal regeneration in the central nervous system following neural injuries. For example, following spinal cord transections, the descending axons of brain neurons regenerate and reconnect with spinal targets so that locomotor behavior recovers in a few …
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Neuron-Glial (NG) Interactions: A Microfluidic Examination of NG Emergent Responses for Repair
… biomedical engineering, including embryogenesis, neural regeneration, growth, and intracellular synaptic activity. However, while NG interactions are known to regulate survival, differentiation, communication, and targeted migration of neural cells, the molecular signals that orchestrate these …
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Thick Conducting Polymer Coatings for Safe Electric Field Delivery to the Spinal Cord
… (SCI) is a devastating condition that disrupts neural pathways in the central nervous system, resulting in sensorimotor dysfunction, loss of independence, and a significant reduction in quality of life. The societal and economic impact is substantial; in the United Kingdom alone, the lifetime …