Global ETD Search
Search theses and dissertations gathered from participating repositories worldwide. Every result links back to the library that holds it. No account is needed.
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Showing 1 to 12 of 12 for “"neural progenitor cell"”.
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Protective effect of JAK3 inhibition on growth factor deprivation induced neural progenitor cell death
… system. The number of embryonic neuroepithelial cells (NECs) is regulated by programmed cell death when NECs are substantially proliferated by growth factors(GFs). The extrinsic factors such as epidermal growth factor (EGF), basic fibroblast growth factor(bFGF), as well as intrinsic protein …
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Engineering hiPSCs to enhance neural progenitor transplantation in degenerative cervical myelopathy
Neural progenitor cell transplantation has been widely explored in traumatic spinal cord injury (SCI) but has yet to be evaluated as a treatment for degenerative cervical myelopathy (DCM), a non-traumatic form of spinal cord injury. Importantly, the extent of astrogliosis and extracellular matrix …
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Light-At-Night and Mood: Examining The Role Of Sex In C57Bl/6 Mice
… of the same animals were used to measure stem cell proliferation in the dentate gyrus using the biomarker Ki-67. Exposure to dim light-at-night did not lead to significant circadian disruption nor to significant changes in any of the parameters examined. Apart from the Forced Swim Test no …
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The Glial Response to Focused Ultrasound-mediated Permeabilization of the Blood-brain Barrier: Evaluating the Potential Contribution of Microglia and Astrocytes to Pathology and Regeneration
… sections by referencing control sample cell morphologies. As validation, identified clusters of activated microglia and astrocytes exhibited hallmark morphological and marker changes. Indeed, activated microglia were deramified and upregulated transforming growth factor beta 1 (Tgfβ1), …
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The Role of Microglia in the Effects of Steroid Hormones on Brain Inflammation
… hormones. However, our comprehension of the cellular targets and mechanisms of action of these hormones in the CNS is still unresolved. In view of these limitations, the main question addressed in this dissertation was the role that microglia play in the anti-inflammatory effects of steroid …
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Characterising molecular and cellular mechanisms of human brain evolution using brain organoids
… of gain-of-function in a subset of radial glial cells. We find that the transcriptional regulator, AUTS2, has a dramatic effect on cell fate and tissue architecture. By generating organoids with loss-of-function of C-terminal-containing AUTS2 isoforms, we find neurogenesis is premature, which may …
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Diterpenes as models for the study of their effect on neural progenitor cells and on cytochrome p-450 enzymes
… C (PKC) are a group of kinases involved in many cell events, and it has recently been proposed that the modulation of their activity may lead to treatments to promote endogenous neurogenesis. Our research group have shown in previous studies that non-tumor pharmacophores like 12- deoxyphorbols …
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The effect of AAV1/2 mediated delivery of brain-derived neurotrophic factor and fibroblast growth factor-2 on adult rodent neurogenesis
… integrated neurons are generated from progenitor cells. In the adult mammalian brain two sites of high density cell division have been identified that contain neural progenitor cells retaining the ability to generate new neurons: the subgranular zone of the hippocampus (SGZ) and the …
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Common Pathophysiological Features of Charcot-Marie-Tooth Disease
… of CMT patients and mouse models to identify neural cell adhesion molecular 1 (NCAM1) and growth differentiation factor 15 (GDF15) as serum biomarkers of CMT. NCAM1 may potentially function as a disease-progression biomarker, whereas GDF15 is indicated to be a very accurate diagnostic …
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TUNING AND TESTING DEVELOPING NEURAL NETWORKS
In vitro neural networks are powerful model systems that can help bridge the gap between single-cell properties and emergent network behaviors. This allows for the linking of cell-scale properties to network behavior, providing an important step in connecting individual cellular actions to the …
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Aberrant hippocampal neurogenesis contributes to learning and memory deficits in a mouse model of repetitive mild traumatic brain injury
… animals. We further identified endothelial cell (EC)-specific EphA4 receptor as a key mediator of aberrant neurogenesis. Taken together, we conclude that increased aberrant neurogenesis contributes to learning and memory deficits after repetitive mild TBI.
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Long-term dispensation and molecular control of endogenous progenitor cells in adult primate telencephalon // Дългосрочна съдба и молекулен контрол на ендогенни прогениторни клетки в краен мозък на възрастни примати
Ние приложихме модел на временна обща мозъчна исхемия на възрастни маймуни (макаки) чрез обратимо прекъсване на мозъчния кръвоток. De novo генерирани клетки в исхемични или контролни субекти бяха белязани с bromodeoxyuridine (BrdU), индикатор за ДНК синтеза. Впоследствие, ние изследвахме …